SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 1k2f SIAH-1A PROTEIN
(Mus
musculus) 		4 / 6 GLU A 122
SER A 242
ARG A 124
TYR A 126
 None
 1.33A 1tufA-1k2fA:
undetectable
1tufB-1k2fA:
undetectable		 1tufA-1k2fA:
17.46
1tufB-1k2fA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1k2f SIAH-1A PROTEIN
(Mus
musculus) 		5 / 12 PHE A 259
ALA A 264
ALA A 268
LEU A 166
MET A 180
 None
 1.08A 2x2nB-1k2fA:
undetectable		 2x2nB-1k2fA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1k2f SIAH-1A PROTEIN
(Mus
musculus) 		5 / 12 PHE A 259
ALA A 264
ALA A 268
LEU A 166
MET A 180
 None
 1.08A 2x2nC-1k2fA:
undetectable		 2x2nC-1k2fA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1k2f SIAH-1A PROTEIN
(Mus
musculus) 		5 / 12 PHE A 259
ALA A 264
ALA A 268
LEU A 166
MET A 180
 None
 1.04A 2x2nD-1k2fA:
undetectable		 2x2nD-1k2fA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 1k2f SIAH-1A PROTEIN
(Mus
musculus) 		5 / 12 ILE A 155
SER A 183
VAL A 144
HIS A 147
HIS A 152
 BME  A 550 (-4.9A)
None
None
ZN  A 601 (-3.0A)
ZN  A 601 (-3.2A)
 1.35A 4rujA-1k2fA:
undetectable		 4rujA-1k2fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1k2f SIAH-1A PROTEIN
(Mus
musculus) 		5 / 12 GLY A 213
HIS A 147
CYH A 128
CYH A 130
GLY A 139
 None
ZN  A 601 (-3.0A)
ZN  A 601 (-2.1A)
BME  A 550 (-2.1A)
None
 1.27A 6bp4B-1k2fA:
undetectable		 6bp4B-1k2fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1k2f SIAH-1A PROTEIN
(Mus
musculus) 		4 / 5 GLY A 229
ASN A 228
ARG A 232
ARG A 233
 None
None
None
BME  A 553 ( 4.3A)
 1.35A 6dwdB-1k2fA:
0.0
6dwdD-1k2fA:
0.0		 6dwdB-1k2fA:
14.26
6dwdD-1k2fA:
14.26