SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 8 HIS A 173
GLY A 128
GLY A 131
LEU A 170
 None
 0.85A 1aegA-1k2wA:
undetectable		 1aegA-1k2wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 9 GLY A  12
ASP A  36
ILE A  37
ALA A  87
ILE A 109
 None
 0.81A 1cetA-1k2wA:
10.9		 1cetA-1k2wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 143
ILE A 160
GLY A 142
ALA A 141
 None
 0.85A 1wmqA-1k2wA:
0.0		 1wmqA-1k2wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 143
ILE A 160
GLY A 142
ALA A 141
 None
 0.86A 1wmqB-1k2wA:
0.0		 1wmqB-1k2wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 143
ILE A 160
GLY A 142
ALA A 141
 None
 0.84A 1wpuA-1k2wA:
0.0		 1wpuA-1k2wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 143
ILE A 160
GLY A 142
ALA A 141
 None
 0.84A 1wpuB-1k2wA:
0.0		 1wpuB-1k2wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 143
ILE A 160
GLY A 142
ALA A 141
 None
 0.87A 1wrqA-1k2wA:
0.0		 1wrqA-1k2wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 143
ILE A 160
GLY A 142
ALA A 141
 None
 0.89A 1wrqB-1k2wA:
0.0		 1wrqB-1k2wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		3 / 3 ARG A 210
VAL A 184
GLY A 252
 None
 0.56A 2avvE-1k2wA:
undetectable		 2avvE-1k2wA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		3 / 3 ASP A  36
ASP A  59
ASN A  86
 None
 0.86A 2bm9D-1k2wA:
6.1		 2bm9D-1k2wA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A  12
ASP A  36
ASP A  59
ASN A  86
ALA A  87
 None
 0.91A 2bm9E-1k2wA:
4.9		 2bm9E-1k2wA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 231
ALA A  24
TYR A  25
THR A 236
ARG A   2
 None
 1.16A 2japA-1k2wA:
31.0		 2japA-1k2wA:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 7 LEU A   9
LEU A  58
ASN A  85
THR A  61
 None
 0.95A 3lm8A-1k2wA:
3.7
3lm8C-1k2wA:
3.0		 3lm8A-1k2wA:
22.63
3lm8C-1k2wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 226
ARG A 223
ASP A 250
 None
 0.90A 4fp9C-1k2wA:
2.7		 4fp9C-1k2wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 226
ARG A 223
ASP A 250
 None
 0.85A 4fp9F-1k2wA:
6.3		 4fp9F-1k2wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 8 SER A 139
GLY A 142
ALA A 147
GLY A 145
 None
 0.91A 5albL-1k2wA:
undetectable		 5albL-1k2wA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 9 ALA A  22
ALA A  14
GLY A  18
ALA A  35
GLY A  12
 None
 1.05A 6bklE-1k2wA:
undetectable
6bklF-1k2wA:
undetectable
6bklG-1k2wA:
undetectable
6bklH-1k2wA:
undetectable		 6bklE-1k2wA:
7.46
6bklF-1k2wA:
7.46
6bklG-1k2wA:
7.46
6bklH-1k2wA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1k2w SORBITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 4 VAL A 216
GLY A 251
ASP A 250
ASP A 226
 None
 1.39A 6cjkC-1k2wA:
undetectable		 6cjkC-1k2wA:
21.48