SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 VAL A 191
GLY A 193
THR A 196
ILE A 213
 None
 0.54A 1gtnC-1k32A:
0.0
1gtnD-1k32A:
0.0		 1gtnC-1k32A:
6.03
1gtnD-1k32A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 TYR A 870
VAL A 871
SER A 875
ILE A1056
 None
 0.87A 1igxA-1k32A:
undetectable		 1igxA-1k32A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.27A 1jhoA-1k32A:
1.9		 1jhoA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 8 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.28A 1jhqA-1k32A:
undetectable		 1jhqA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.28A 1jhrA-1k32A:
1.6		 1jhrA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.27A 1jhyA-1k32A:
undetectable		 1jhyA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 SER A 971
GLY A1026
THR A 987
GLY A 984
 None
 0.81A 1jr1B-1k32A:
undetectable		 1jr1B-1k32A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 ARG A 998
GLY A 380
ASP A 385
 None
 0.59A 1kf6A-1k32A:
undetectable
1kf6B-1k32A:
0.0		 1kf6A-1k32A:
19.45
1kf6B-1k32A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.29A 1l4nA-1k32A:
1.7		 1l4nA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.26A 1l5kA-1k32A:
1.6		 1l5kA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.29A 1l5lA-1k32A:
1.6		 1l5lA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.29A 1l5mA-1k32A:
1.7		 1l5mA-1k32A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 8 LEU A 825
ILE A 810
GLU A 813
VAL A 815
ILE A 807
 None
 1.45A 1linA-1k32A:
undetectable		 1linA-1k32A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 6 PHE A  86
ARG A  52
ILE A  48
GLY A  50
 None
 1.10A 1oniA-1k32A:
0.3
1oniB-1k32A:
0.5		 1oniA-1k32A:
11.00
1oniB-1k32A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 6 PHE A  86
ARG A  52
ILE A  48
GLY A  50
 None
 1.07A 1oniD-1k32A:
0.3
1oniF-1k32A:
0.3		 1oniD-1k32A:
11.00
1oniF-1k32A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 GLU A 312
TRP A  62
LYS A 324
 None
 0.79A 1qu2A-1k32A:
0.0		 1qu2A-1k32A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 GLN A 253
ILE A 254
TYR A 255
 None
 0.72A 1vifA-1k32A:
undetectable		 1vifA-1k32A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 8 GLY A 917
GLY A 918
SER A 965
ILE A 994
HIS A 746
 None
 0.95A 1yajC-1k32A:
undetectable		 1yajC-1k32A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 8 GLY A 917
GLY A 918
SER A 965
ILE A 994
HIS A 746
 None
 1.03A 1yajC-1k32A:
undetectable		 1yajC-1k32A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 4 GLY A 918
SER A 965
ILE A 994
HIS A 746
 None
 1.10A 1yajJ-1k32A:
undetectable		 1yajJ-1k32A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A 168
ILE A  93
VAL A  97
 None
 0.70A 2avvD-1k32A:
undetectable		 2avvD-1k32A:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 TRP A 863
LYS A 780
PRO A 155
 None
 1.45A 2dqyB-1k32A:
2.1		 2dqyB-1k32A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 6 ASP A 227
THR A 985
GLU A1032
GLU A 961
 None
 1.27A 2dttB-1k32A:
1.2
2dttC-1k32A:
1.6		 2dttB-1k32A:
8.45
2dttC-1k32A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 4 ASP A1028
ASP A1030
ASP A 968
GLY A 984
 None
 1.36A 2igtC-1k32A:
undetectable		 2igtC-1k32A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 PHE A 769
ILE A 807
ILE A 835
ALA A 833
THR A 831
 None
 1.18A 2j0dA-1k32A:
0.0		 2j0dA-1k32A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A 699
ASN A 700
THR A 744
 None
 0.81A 2q63B-1k32A:
undetectable		 2q63B-1k32A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 TYR A 273
TYR A 729
THR A 727
THR A1004
 None
 1.19A 2v0zO-1k32A:
undetectable		 2v0zO-1k32A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 ASP A1053
VAL A 871
ARG A 874
ILE A1048
 None
 1.15A 2yfbA-1k32A:
undetectable		 2yfbA-1k32A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 SER A 762
ARG A 120
GLY A 169
ASN A 171
TYR A 163
 None
 1.46A 3a27A-1k32A:
0.0		 3a27A-1k32A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 PHE A 914
ALA A 963
THR A 209
GLY A1026
LEU A 982
 None
 1.20A 3aobC-1k32A:
2.6		 3aobC-1k32A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 6 THR A1004
ILE A 735
SER A 732
LEU A 731
 None
 0.87A 3deuB-1k32A:
0.0		 3deuB-1k32A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 GLY A 388
ILE A 364
VAL A 367
VAL A 375
 None
 0.74A 3fi0G-1k32A:
undetectable		 3fi0G-1k32A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 GLY A 388
ILE A 364
VAL A 367
VAL A 375
 None
 0.71A 3fi0I-1k32A:
undetectable		 3fi0I-1k32A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 GLY A 388
ILE A 364
VAL A 367
VAL A 375
 None
 0.75A 3fi0Q-1k32A:
undetectable		 3fi0Q-1k32A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 10 LEU A 825
VAL A 778
ALA A 833
ILE A 835
LEU A 837
 None
 1.14A 3fl9A-1k32A:
undetectable		 3fl9A-1k32A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 MET A  39
CYH A  57
PRO A 314
 None
 1.28A 3h52C-1k32A:
0.0		 3h52C-1k32A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 ASN A 867
ASP A1045
ARG A 132
 None
 0.79A 3k13C-1k32A:
undetectable		 3k13C-1k32A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 PRO A 802
ILE A 765
LEU A 825
ILE A 807
 None
 0.95A 3p50A-1k32A:
2.2		 3p50A-1k32A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 PRO A 802
ILE A 765
LEU A 825
ILE A 807
 None
 0.95A 3p50B-1k32A:
2.6		 3p50B-1k32A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 PRO A 802
ILE A 765
LEU A 825
ILE A 807
 None
 0.95A 3p50C-1k32A:
0.0		 3p50C-1k32A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 PRO A 802
ILE A 765
LEU A 825
ILE A 807
 None
 0.95A 3p50D-1k32A:
2.2		 3p50D-1k32A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 PRO A 802
ILE A 765
LEU A 825
ILE A 807
 None
 0.94A 3p50E-1k32A:
2.2		 3p50E-1k32A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 6 THR A 755
SER A 128
ASP A 758
THR A 753
 None
 1.02A 3q70A-1k32A:
undetectable		 3q70A-1k32A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 139
ILE A 183
PRO A 235
ILE A 242
ILE A 237
 None
 1.10A 3s56B-1k32A:
undetectable		 3s56B-1k32A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 HIS A 746
GLY A 993
GLY A 918
SER A 965
SER A 158
 None
 1.18A 3sueD-1k32A:
undetectable		 3sueD-1k32A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 10 ILE A  53
SER A  70
ILE A 306
GLU A 304
ARG A 284
 None
 1.44A 3u6tA-1k32A:
undetectable		 3u6tA-1k32A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 PRO A 802
LEU A 825
ILE A 821
TYR A 822
ALA A 779
 None
 1.39A 4a83A-1k32A:
0.0		 4a83A-1k32A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 VAL A  75
ILE A  95
GLU A 312
ILE A 308
VAL A  97
 None
 1.34A 4a97B-1k32A:
0.0
4a97C-1k32A:
2.9		 4a97B-1k32A:
15.06
4a97C-1k32A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 6 SER A 234
THR A 246
ILE A 245
THR A 181
 None
 0.95A 4acbC-1k32A:
3.0		 4acbC-1k32A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 ILE A 303
ILE A 285
LEU A 278
ILE A 254
 None
 0.88A 4dtaB-1k32A:
undetectable		 4dtaB-1k32A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 ARG A 868
ILE A 882
ASP A 886
GLY A 891
PHE A 895
 None
 1.44A 4eb4C-1k32A:
0.0		 4eb4C-1k32A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 7 PHE A 124
ASN A 171
GLY A 169
THR A 122
ILE A 148
 None
 1.42A 4ejjA-1k32A:
undetectable		 4ejjA-1k32A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 SER A 747
GLU A1023
TYR A1025
ARG A 986
 None
 0.98A 4fgzA-1k32A:
undetectable
4fgzB-1k32A:
undetectable		 4fgzA-1k32A:
14.20
4fgzB-1k32A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 ASN A 550
VAL A 624
TYR A 622
ARG A 627
 None
 1.16A 4ijiH-1k32A:
undetectable		 4ijiH-1k32A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 GLY A1003
ASP A1002
GLY A 751
GLU A 749
 None
 0.93A 4koeA-1k32A:
undetectable
4koeB-1k32A:
undetectable
4koeD-1k32A:
undetectable		 4koeA-1k32A:
19.58
4koeB-1k32A:
19.58
4koeD-1k32A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 9 GLY A 411
GLY A 416
PHE A 418
LEU A 433
GLY A 370
 None
 1.28A 4kqiA-1k32A:
undetectable		 4kqiA-1k32A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 SER A 965
TYR A 748
ILE A 994
GLU A1023
 None
 1.14A 4ms4A-1k32A:
3.4		 4ms4A-1k32A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 6 ARG A  85
ALA A  94
ASP A  47
LEU A 146
 None
 1.06A 4ot2A-1k32A:
undetectable		 4ot2A-1k32A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 ARG A 728
LEU A1006
ASP A1002
LEU A1000
PHE A 754
 None
 1.46A 4pbhA-1k32A:
0.0		 4pbhA-1k32A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 ALA A 376
GLY A 416
LEU A 433
LEU A 387
 None
 0.83A 4po0A-1k32A:
undetectable		 4po0A-1k32A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 THR A 105
ASN A 104
SER A 128
 None
 0.77A 4tvtA-1k32A:
0.0		 4tvtA-1k32A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 5 GLY A 583
TYR A 598
SER A 599
ASP A 584
 None
 1.07A 4xueA-1k32A:
undetectable		 4xueA-1k32A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		3 / 3 LYS A 981
ILE A 983
ILE A1033
 None
 0.69A 4y0qA-1k32A:
undetectable		 4y0qA-1k32A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 PHE A 140
LEU A 146
ALA A  94
ARG A  96
LEU A 184
 None
 1.18A 5h8tA-1k32A:
undetectable		 5h8tA-1k32A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 VAL A 191
LEU A 184
ILE A 248
ILE A 213
LEU A 264
 None
 1.15A 5hbsA-1k32A:
undetectable		 5hbsA-1k32A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 ASP A 811
ALA A 833
ASP A 853
GLY A 763
GLU A 827
 None
 1.10A 5hfjA-1k32A:
undetectable		 5hfjA-1k32A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 ASP A 811
ALA A 833
ASP A 853
GLY A 763
GLU A 827
 None
 1.21A 5hfjD-1k32A:
undetectable		 5hfjD-1k32A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 8 VAL A 871
ILE A 956
ILE A1052
ILE A 983
ASP A 911
 None
 1.34A 5hi2A-1k32A:
undetectable		 5hi2A-1k32A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 GLY A 790
ALA A 766
ASP A 854
ASN A 788
 None
 1.01A 5mvsA-1k32A:
2.4		 5mvsA-1k32A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 GLY A 790
ALA A 766
ASP A 854
ASN A 788
 None
 0.98A 5mvsB-1k32A:
undetectable		 5mvsB-1k32A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 LEU A 264
PHE A 244
MET A 228
ILE A 254
 None
 0.96A 5mzjA-1k32A:
2.4		 5mzjA-1k32A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 VAL A 367
ILE A 364
PRO A 359
ALA A 345
 None
 0.71A 5ospA-1k32A:
0.8		 5ospA-1k32A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 7 VAL A 367
ILE A 364
PRO A 359
ALA A 345
 None
 0.72A 5osrA-1k32A:
0.7		 5osrA-1k32A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 THR A 209
THR A 985
ARG A 913
GLN A1047
 None
 1.08A 5tzoA-1k32A:
undetectable		 5tzoA-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 TRP A 214
THR A 985
ARG A 913
GLN A1047
 None
 1.32A 5tzoA-1k32A:
undetectable		 5tzoA-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 THR A 209
THR A 985
ARG A 913
GLN A1047
 None
 0.93A 5tzoB-1k32A:
undetectable		 5tzoB-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 THR A 209
THR A 985
ARG A 913
GLN A1047
 None
 1.03A 5tzoC-1k32A:
undetectable		 5tzoC-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 8 TRP A 214
THR A 985
ARG A 913
GLN A1047
 None
 1.33A 5tzoC-1k32A:
undetectable		 5tzoC-1k32A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A  93
ILE A  54
ILE A  81
VAL A 137
HIS A 277
 None
 0.91A 5uvmB-1k32A:
undetectable		 5uvmB-1k32A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 GLU A 442
ASP A 451
GLY A 464
PHE A 465
ALA A 409
 None
 1.24A 5x5qB-1k32A:
undetectable		 5x5qB-1k32A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 7 GLY A 918
GLY A 917
GLY A 964
GLY A 989
GLY A 990
 None
 0.90A 6ag0A-1k32A:
undetectable		 6ag0A-1k32A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		5 / 12 VAL A 815
MET A 153
PHE A 796
THR A 803
GLY A 804
 None
 1.37A 6brdA-1k32A:
undetectable		 6brdA-1k32A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1k32 TRICORN PROTEASE
(Thermoplasma
acidophilum) 		4 / 5 GLY A 384
ASN A 406
ASP A 385
ARG A 998
 None
 1.40A 6dwdB-1k32A:
0.0
6dwdD-1k32A:
0.0		 6dwdB-1k32A:
19.58
6dwdD-1k32A:
19.58