SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
(Homo
sapiens) 		4 / 6 THR A  99
PHE A 113
PHE A  68
GLY A 115
 None
 1.14A 1kqbA-1k3bA:
undetectable
1kqbB-1k3bA:
0.0		 1kqbA-1k3bA:
21.00
1kqbB-1k3bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
(Homo
sapiens) 		4 / 6 THR A  99
PHE A 113
PHE A  68
GLY A 115
 None
 1.15A 1kqbC-1k3bA:
0.0
1kqbD-1k3bA:
0.0		 1kqbC-1k3bA:
21.00
1kqbD-1k3bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
DIPEPTYDIL-PEPTIDASE
I LIGHT CHAIN
(Homo
sapiens) 		4 / 7 ALA A   4
TYR A  83
TYR B 235
PHE A  80
 None
 1.20A 2ajvH-1k3bA:
2.1
2ajvL-1k3bA:
undetectable		 2ajvH-1k3bA:
20.81
2ajvL-1k3bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1k3b DIPEPTYDIL-PEPTIDASE
I LIGHT CHAIN
(Homo
sapiens) 		3 / 3 ARG B 226
GLN B 262
PRO B 261
 SO4  B 502 (-3.9A)
None
None
 0.98A 2qhfA-1k3bB:
0.0		 2qhfA-1k3bB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
DIPEPTYDIL-PEPTIDASE
I LIGHT CHAIN
(Homo
sapiens) 		4 / 5 PHE A 113
SER B 268
PHE A  68
ILE B 282
 None
 1.02A 2v0mD-1k3bA:
0.0		 2v0mD-1k3bA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
(Homo
sapiens) 		5 / 12 ALA A  50
ASP A  52
GLY A  13
LEU A  12
ILE A  70
 None
 0.97A 3em6B-1k3bA:
undetectable		 3em6B-1k3bA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
(Homo
sapiens) 		3 / 3 ALA A  79
VAL A 102
TRP A  77
 None
 0.85A 3l8lC-1k3bA:
undetectable
3l8lD-1k3bA:
undetectable		 3l8lC-1k3bA:
10.75
3l8lD-1k3bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
DIPEPTYDIL-PEPTIDASE
I LIGHT CHAIN
(Homo
sapiens) 		5 / 12 PHE A  80
SER B 268
THR A  97
ILE B 282
ALA B 287
 None
 1.15A 3nxuB-1k3bA:
undetectable		 3nxuB-1k3bA:
12.18