SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A  71
THR A  25
VAL A  84
 None
 0.96A 1hxbA-1k3rA:
0.0		 1hxbA-1k3rA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  61
ILE A  57
ALA A  35
VAL A  40
THR A 246
 None
 1.32A 2qo4A-1k3rA:
undetectable		 2qo4A-1k3rA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  61
ILE A  57
ALA A  35
VAL A  40
THR A 246
 None
 1.32A 2qo6A-1k3rA:
undetectable		 2qo6A-1k3rA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		6 / 12 ILE A  57
ASP A  12
THR A  15
VAL A  28
ILE A  31
ILE A  10
 None
 1.24A 2yzqA-1k3rA:
0.0		 2yzqA-1k3rA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A  57
THR A  15
VAL A  28
ILE A  31
ILE A  10
 None
 1.13A 3kpbA-1k3rA:
undetectable		 3kpbA-1k3rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A  57
THR A  15
VAL A  28
ILE A  31
ILE A  10
 None
 1.14A 3kpbC-1k3rA:
0.0		 3kpbC-1k3rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ILE A  57
THR A  15
VAL A  28
ILE A  31
ILE A  10
 None
 1.14A 3kpbD-1k3rA:
undetectable		 3kpbD-1k3rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A  57
THR A  15
VAL A  28
ILE A  31
ILE A  10
 None
 1.17A 3kpdB-1k3rA:
0.0		 3kpdB-1k3rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		3 / 4 SER A 177
GLY A  52
GLU A  17
 None
 0.61A 3raeA-1k3rA:
undetectable
3raeC-1k3rA:
undetectable		 3raeA-1k3rA:
24.47
3raeC-1k3rA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 TYR A 165
ILE A  43
VAL A 167
ILE A  57
ILE A  31
 None
 1.28A 3vrjA-1k3rA:
undetectable
3vrjC-1k3rA:
undetectable		 3vrjA-1k3rA:
19.03
3vrjC-1k3rA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ILE A 227
LEU A 216
VAL A 181
GLY A 182
 None
 0.90A 3w1wA-1k3rA:
undetectable		 3w1wA-1k3rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		3 / 4 SER A 177
GLY A  52
GLU A  17
 None
 0.60A 4juoA-1k3rA:
0.0
4juoC-1k3rA:
undetectable		 4juoA-1k3rA:
24.47
4juoC-1k3rA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 260
LEU A   6
VAL A 185
ALA A 213
ILE A 231
 None
 1.15A 4x1kD-1k3rA:
undetectable		 4x1kD-1k3rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ILE A 231
LEU A   6
LEU A 254
MET A 207
 None
 0.99A 4xtaB-1k3rA:
undetectable		 4xtaB-1k3rA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A 189
GLY A 218
GLY A 223
GLN A 239
ALA A 249
 None
 0.93A 5l0zA-1k3rA:
11.8		 5l0zA-1k3rA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLY A 218
ARG A 245
THR A 246
GLU A 247
ALA A 249
 None
 0.97A 5o96G-1k3rA:
13.3		 5o96G-1k3rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1k3r CONSERVED PROTEIN
MT0001
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  61
ILE A  60
PHE A  56
LEU A  30
VAL A 250
 None
 1.45A 5uanB-1k3rA:
0.0		 5uanB-1k3rA:
18.92