SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		5 / 8 VAL A  64
VAL A 190
VAL A 121
ILE A  55
LEU A   2
 None
 1.34A 1igxA-1k4jA:
undetectable		 1igxA-1k4jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 5 TYR A  54
SER A   8
TYR A   9
ARG A  68
 None
 1.41A 2kqeA-1k4jA:
0.0		 2kqeA-1k4jA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 7 ILE A 141
PHE A  86
ARG A 170
THR A 166
 REO  A 407 (-4.6A)
None
None
None
 1.00A 3ag2N-1k4jA:
0.0
3ag2W-1k4jA:
0.0		 3ag2N-1k4jA:
18.26
3ag2W-1k4jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 7 LEU A 122
PHE A 123
ARG A 152
MET A 146
 None
None
None
REO  A 403 (-3.6A)
 1.05A 3ag2N-1k4jA:
0.0
3ag2W-1k4jA:
0.0		 3ag2N-1k4jA:
18.26
3ag2W-1k4jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		3 / 3 LEU A  91
PRO A  92
LEU A  72
 None
 0.48A 3hcrA-1k4jA:
0.6		 3hcrA-1k4jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 7 ILE A 118
LEU A 112
VAL A  36
SER A  39
 None
 0.99A 3r9vA-1k4jA:
2.2
3r9vB-1k4jA:
undetectable		 3r9vA-1k4jA:
22.22
3r9vB-1k4jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 5 LEU A  63
GLY A  41
PHE A 102
ARG A 107
 None
 1.17A 3smtA-1k4jA:
undetectable		 3smtA-1k4jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 7 GLU A  10
ARG A  68
TYR A  54
GLY A  51
 None
None
None
REO  A 406 (-4.4A)
 0.82A 4rdxA-1k4jA:
undetectable		 4rdxA-1k4jA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		3 / 3 ASN A  76
PHE A  69
TYR A  54
 None
 0.74A 4u15A-1k4jA:
undetectable		 4u15A-1k4jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		3 / 3 ARG A  53
ASP A   6
TRP A 129
 None
 0.50A 4xdqA-1k4jA:
undetectable		 4xdqA-1k4jA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 5 LEU A 176
ALA A 130
VAL A  67
ILE A  55
 None
 0.94A 4xe3A-1k4jA:
undetectable		 4xe3A-1k4jA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 6 ILE A 141
PHE A  86
ARG A 170
THR A 166
 REO  A 407 (-4.6A)
None
None
None
 1.03A 5b1aN-1k4jA:
0.1
5b1aW-1k4jA:
0.0		 5b1aN-1k4jA:
18.26
5b1aW-1k4jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 7 ILE A 141
PHE A  86
ARG A 170
THR A 166
 REO  A 407 (-4.6A)
None
None
None
 0.90A 5b3sN-1k4jA:
0.0
5b3sW-1k4jA:
0.0		 5b3sN-1k4jA:
18.26
5b3sW-1k4jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		3 / 3 ARG A 144
PHE A 101
LEU A 174
 None
 0.80A 5veuA-1k4jA:
undetectable		 5veuA-1k4jA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 5 ILE A 141
PHE A  86
ARG A 170
THR A 166
 REO  A 407 (-4.6A)
None
None
None
 0.86A 5z84N-1k4jA:
0.9
5z84W-1k4jA:
0.0		 5z84N-1k4jA:
18.26
5z84W-1k4jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 8 ILE A 141
PHE A  86
ARG A 170
THR A 166
 REO  A 407 (-4.6A)
None
None
None
 0.83A 5zcpN-1k4jA:
0.0
5zcpW-1k4jA:
0.0		 5zcpN-1k4jA:
18.26
5zcpW-1k4jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		5 / 9 LEU A 206
GLY A 187
LEU A 124
GLN A 120
THR A 194
 None
None
None
None
REO  A 405 ( 4.9A)
 1.14A 6czmA-1k4jA:
0.0
6czmB-1k4jA:
0.0		 6czmA-1k4jA:
20.06
6czmB-1k4jA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		5 / 8 GLY A 187
LEU A 124
GLN A 120
THR A 194
LEU A 206
 None
None
None
REO  A 405 ( 4.9A)
None
 1.16A 6czmD-1k4jA:
undetectable
6czmF-1k4jA:
undetectable		 6czmD-1k4jA:
20.06
6czmF-1k4jA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI
(Pantoea
stewartii) 		4 / 8 ASP A  48
SER A  44
TYR A  54
GLY A  57
 None
 1.04A 6giqL-1k4jA:
0.0
6giqP-1k4jA:
0.0
6giqT-1k4jA:
undetectable		 6giqL-1k4jA:
19.31
6giqP-1k4jA:
20.78
6giqT-1k4jA:
15.22