SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1k4l 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Magnaporthe
grisea) 		4 / 7 ALA A 156
GLU A 159
LEU A 160
VAL A  28
 None
 0.92A 1hk2A-1k4lA:
undetectable		 1hk2A-1k4lA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1k4l 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Magnaporthe
grisea) 		5 / 11 LEU A  77
PHE A 131
ALA A 117
ALA A  46
ALA A 123
 None
 0.87A 3mdtB-1k4lA:
0.0		 3mdtB-1k4lA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1k4l 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Magnaporthe
grisea) 		4 / 8 ALA A 126
PRO A 124
GLU A  72
LEU A  77
 None
 0.81A 4jjkA-1k4lA:
undetectable		 4jjkA-1k4lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1k4l 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Magnaporthe
grisea) 		3 / 3 ARG A 150
HIS A 153
ARG A  36
 SO4  A1001 (-2.9A)
MN  A1003 ( 3.4A)
SO4  A1001 (-2.9A)
 1.09A 5iaoC-1k4lA:
0.0		 5iaoC-1k4lA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1k4l 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Magnaporthe
grisea) 		3 / 3 ARG A 150
HIS A 153
ARG A  36
 SO4  A1001 (-2.9A)
MN  A1003 ( 3.4A)
SO4  A1001 (-2.9A)
 1.14A 5iaoF-1k4lA:
0.0		 5iaoF-1k4lA:
25.81