SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY A   9
HIS A  16
HIS A  19
GLY A 107
ASP A 109
 NAD  A 601 (-3.1A)
None
NAD  A 601 (-4.5A)
NAD  A 601 (-3.1A)
NAD  A 601 ( 2.9A)
 0.78A 1jzsA-1k4mA:
0.0		 1jzsA-1k4mA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  16
GLY A  18
HIS A  19
GLY A 107
ASP A 109
 None
NAD  A 601 (-3.8A)
NAD  A 601 (-4.5A)
NAD  A 601 (-3.1A)
NAD  A 601 ( 2.9A)
 0.34A 1pg2A-1k4mA:
4.9		 1pg2A-1k4mA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 HIS A  16
GLY A  18
HIS A  19
GLY A 107
ASP A 109
 None
NAD  A 601 (-3.8A)
NAD  A 601 (-4.5A)
NAD  A 601 (-3.1A)
NAD  A 601 ( 2.9A)
 0.98A 1qu2A-1k4mA:
2.7		 1qu2A-1k4mA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  16
GLY A  18
HIS A  19
GLY A 107
ASP A 109
 None
NAD  A 601 (-3.8A)
NAD  A 601 (-4.5A)
NAD  A 601 (-3.1A)
NAD  A 601 ( 2.9A)
 0.57A 2x1lA-1k4mA:
5.0		 2x1lA-1k4mA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 HIS A  16
GLY A  18
HIS A  19
GLY A 107
ASP A 109
 None
NAD  A 601 (-3.8A)
NAD  A 601 (-4.5A)
NAD  A 601 (-3.1A)
NAD  A 601 ( 2.9A)
 0.52A 2x1lB-1k4mA:
4.7		 2x1lB-1k4mA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  16
GLY A  18
HIS A  19
GLY A 107
ASP A 109
 None
NAD  A 601 (-3.8A)
NAD  A 601 (-4.5A)
NAD  A 601 (-3.1A)
NAD  A 601 ( 2.9A)
 0.57A 2x1lC-1k4mA:
5.0		 2x1lC-1k4mA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A 188
GLY A 191
GLU A 186
CYH A 194
 None
 1.19A 3aiaA-1k4mA:
1.4
3aiaB-1k4mA:
2.4		 3aiaA-1k4mA:
21.46
3aiaB-1k4mA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A 120
PRO A 115
TYR A 146
ILE A 169
 None
 0.75A 3p4wC-1k4mA:
undetectable		 3p4wC-1k4mA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 THR A 155
LEU A   4
LYS A   2
GLN A  96
 None
 1.12A 4ib4A-1k4mA:
0.0		 4ib4A-1k4mA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 VAL A  15
LEU A  72
ILE A  64
ALA A  63
 None
 0.73A 4zf8A-1k4mA:
0.0		 4zf8A-1k4mA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 HIS A  16
GLY A  18
HIS A  19
GLY A 107
ASP A 109
 None
NAD  A 601 (-3.8A)
NAD  A 601 (-4.5A)
NAD  A 601 (-3.1A)
NAD  A 601 ( 2.9A)
 1.01A 5hg0B-1k4mA:
7.0		 5hg0B-1k4mA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 PRO A 175
VAL A  35
LEU A 161
ILE A  30
LEU A  32
 None
 1.18A 5ienA-1k4mA:
0.0		 5ienA-1k4mA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 GLY A  10
THR A  11
HIS A  19
SER A 180
 NAD  A 601 (-3.4A)
NAD  A 601 (-4.7A)
NAD  A 601 (-4.5A)
CIT  A 604 (-3.5A)
 0.66A 6jmjA-1k4mA:
15.0		 6jmjA-1k4mA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 GLY A  10
PHE A  12
HIS A  19
SER A 180
 NAD  A 601 (-3.4A)
NAD  A 601 (-4.5A)
NAD  A 601 (-4.5A)
CIT  A 604 (-3.5A)
 0.56A 6jnhA-1k4mA:
15.0		 6jnhA-1k4mA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1k4m NAMN
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 GLY A  10
THR A  11
PHE A  12
HIS A  19
 NAD  A 601 (-3.4A)
NAD  A 601 (-4.7A)
NAD  A 601 (-4.5A)
NAD  A 601 (-4.5A)
 0.40A 6jnhA-1k4mA:
15.0		 6jnhA-1k4mA:
25.57