SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 8 GLY A 142
GLU A 220
SER A 221
HIS A 467
 None
 0.86A 1ax9A-1k4yA:
51.3		 1ax9A-1k4yA:
36.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 PHE A 178
LEU A 285
ILE A 269
ALA A 268
ALA A 264
 None
 1.00A 1cbsA-1k4yA:
undetectable		 1cbsA-1k4yA:
14.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 141
GLY A 142
GLY A 143
SER A 221
HIS A 467
 None
 0.68A 1dx6A-1k4yA:
51.3		 1dx6A-1k4yA:
35.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.40A 1fohA-1k4yA:
undetectable		 1fohA-1k4yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.41A 1fohB-1k4yA:
0.0		 1fohB-1k4yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.38A 1fohC-1k4yA:
undetectable		 1fohC-1k4yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.40A 1fohD-1k4yA:
undetectable		 1fohD-1k4yA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 8 GLY A 142
GLU A 220
SER A 221
HIS A 467
 None
 0.94A 1maaD-1k4yA:
43.7		 1maaD-1k4yA:
33.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		7 / 11 LEU A  97
PHE A 101
GLY A 142
GLY A 143
SER A 221
LEU A 255
HIS A 467
 None
 0.62A 1mx1A-1k4yA:
64.8		 1mx1A-1k4yA:
82.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 11 LEU A  97
PHE A 101
GLY A 142
SER A 221
HIS A 467
 None
 0.68A 1mx1B-1k4yA:
63.5		 1mx1B-1k4yA:
82.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A  97
GLY A 142
SER A 221
LEU A 255
HIS A 467
 None
 0.58A 1mx1C-1k4yA:
64.4		 1mx1C-1k4yA:
82.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		6 / 12 LEU A  97
GLY A 142
GLY A 143
SER A 221
LEU A 255
HIS A 467
 None
 0.53A 1mx1D-1k4yA:
64.0		 1mx1D-1k4yA:
82.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A  97
GLY A 142
VAL A 146
SER A 221
HIS A 467
 None
 0.72A 1mx1E-1k4yA:
63.9		 1mx1E-1k4yA:
82.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 142
GLY A 143
SER A 221
LEU A 255
HIS A 467
 None
 0.60A 1mx1F-1k4yA:
63.7		 1mx1F-1k4yA:
82.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 THR A 123
LEU A 127
VAL A  26
THR A  80
VAL A  53
 None
 1.45A 1o76A-1k4yA:
0.0		 1o76A-1k4yA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.44A 1pn0A-1k4yA:
0.7		 1pn0A-1k4yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.43A 1pn0B-1k4yA:
0.0		 1pn0B-1k4yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.39A 1pn0C-1k4yA:
0.7		 1pn0C-1k4yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.39A 1pn0D-1k4yA:
0.8		 1pn0D-1k4yA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		6 / 12 GLY A 141
GLY A 142
GLY A 143
GLU A 220
SER A 221
HIS A 467
 None
 0.80A 1qtiA-1k4yA:
51.5		 1qtiA-1k4yA:
36.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 141
GLY A 142
GLY A 143
SER A 221
HIS A 467
 None
 0.69A 1w6rA-1k4yA:
51.3		 1w6rA-1k4yA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 11 GLY A 142
GLY A 143
GLU A 220
SER A 221
HIS A 467
 None
 0.76A 1w76A-1k4yA:
52.2		 1w76A-1k4yA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 GLY A 141
GLY A 142
GLU A 220
SER A 221
HIS A 467
 None
 0.69A 1w76B-1k4yA:
52.1		 1w76B-1k4yA:
35.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 5 TRP A 499
ILE A 244
LEU A 157
ALA A 500
 None
 0.90A 1xvaA-1k4yA:
2.2
1xvaB-1k4yA:
2.3		 1xvaA-1k4yA:
20.80
1xvaB-1k4yA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 6 ALA A 500
TRP A 499
ILE A 244
LEU A 157
 None
 0.98A 1xvaA-1k4yA:
2.3
1xvaB-1k4yA:
2.3		 1xvaA-1k4yA:
20.80
1xvaB-1k4yA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 PHE A 101
GLY A 142
GLY A 143
SER A 221
HIS A 467
 None
 0.77A 1ya4C-1k4yA:
64.1		 1ya4C-1k4yA:
82.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		6 / 8 GLY A 141
GLY A 142
GLY A 143
SER A 221
ALA A 222
HIS A 467
 None
 0.73A 1yajC-1k4yA:
62.8		 1yajC-1k4yA:
82.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		6 / 8 GLY A 223
GLY A 141
GLY A 142
SER A 221
ALA A 222
HIS A 467
 None
 1.27A 1yajC-1k4yA:
62.8		 1yajC-1k4yA:
82.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 9 GLY A 142
GLY A 143
SER A 221
ALA A 222
HIS A 467
 None
 0.76A 2aceA-1k4yA:
52.6		 2aceA-1k4yA:
36.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 7 LEU A 475
GLY A 223
ILE A 139
VAL A 474
ILE A 471
 None
 1.19A 2aojB-1k4yA:
undetectable		 2aojB-1k4yA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 9 LEU A 475
GLY A 223
ILE A 139
VAL A 474
ILE A 471
 None
 1.10A 2avoA-1k4yA:
undetectable		 2avoA-1k4yA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 PHE A 178
LEU A 285
ILE A 269
ALA A 268
ALA A 264
 None
 1.08A 2fr3A-1k4yA:
undetectable		 2fr3A-1k4yA:
14.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 8 TYR A 152
GLU A 220
HIS A 467
GLY A 468
 None
 0.69A 2ha4A-1k4yA:
48.5		 2ha4A-1k4yA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 8 GLY A 142
GLY A 143
ALA A 222
HIS A 467
 None
 0.41A 2ha4A-1k4yA:
48.5		 2ha4A-1k4yA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 7 TYR A 152
GLU A 220
HIS A 467
GLY A 468
 None
 0.74A 2ha4B-1k4yA:
49.9		 2ha4B-1k4yA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 7 GLY A 142
GLY A 143
ALA A 222
HIS A 467
 None
 0.44A 2ha4B-1k4yA:
49.9		 2ha4B-1k4yA:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 11 ILE A 334
ASN A 238
LEU A 232
THR A 320
PRO A 328
 None
 1.36A 3a50B-1k4yA:
0.0		 3a50B-1k4yA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 HIS A 467
GLY A 426
LEU A 252
ASP A 418
LEU A 538
 None
 1.28A 3cjtK-1k4yA:
2.0		 3cjtK-1k4yA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 11 PRO A  54
LEU A  51
VAL A  49
ALA A  48
PHE A 208
 None
 1.30A 3n23C-1k4yA:
undetectable		 3n23C-1k4yA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		3 / 3 GLU A 353
PHE A 425
GLN A 352
 None
 1.02A 3r55A-1k4yA:
0.0		 3r55A-1k4yA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 141
GLY A 142
GLY A 143
SER A 221
HIS A 467
 None
 0.68A 4ey6A-1k4yA:
49.8		 4ey6A-1k4yA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		6 / 12 GLY A 141
GLY A 142
GLY A 143
GLU A 220
SER A 221
HIS A 467
 None
 0.71A 4ey6B-1k4yA:
44.1		 4ey6B-1k4yA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 11 GLY A 142
GLU A 220
SER A 221
HIS A 467
GLY A 468
 None
 0.90A 4ey7A-1k4yA:
49.7		 4ey7A-1k4yA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 11 GLY A 142
GLU A 220
SER A 221
HIS A 467
GLY A 468
 None
 0.90A 4ey7B-1k4yA:
49.0		 4ey7B-1k4yA:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 210
GLY A 131
LEU A 127
ILE A 205
VAL A 164
 None
 1.11A 4fr0A-1k4yA:
undetectable		 4fr0A-1k4yA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 7 ILE A 229
LEU A 327
ASP A 323
THR A 260
 None
 1.02A 4mmcA-1k4yA:
0.0		 4mmcA-1k4yA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A 372
LEU A 380
ALA A 377
LEU A 420
LEU A 403
 None
 1.11A 4p65A-1k4yA:
undetectable
4p65B-1k4yA:
undetectable
4p65F-1k4yA:
undetectable
4p65H-1k4yA:
undetectable		 4p65A-1k4yA:
15.56
4p65B-1k4yA:
3.65
4p65F-1k4yA:
3.65
4p65H-1k4yA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A 172
GLY A 143
THR A 297
ILE A 174
PHE A 302
 None
 1.48A 4p6xA-1k4yA:
0.0		 4p6xA-1k4yA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA703_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 4 LEU A 417
PHE A 416
LEU A 424
GLU A 353
 None
 1.20A 4p7nA-1k4yA:
0.6		 4p7nA-1k4yA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		4 / 7 ILE A 229
HIS A 191
LEU A 230
GLY A 223
 None
 1.00A 4z69A-1k4yA:
2.6		 4z69A-1k4yA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.87A 5ec8C-1k4yA:
undetectable		 5ec8C-1k4yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.89A 5ehgA-1k4yA:
undetectable		 5ehgA-1k4yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.88A 5eifA-1k4yA:
undetectable		 5eifA-1k4yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.90A 5eifC-1k4yA:
1.6		 5eifC-1k4yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.93A 5ikmA-1k4yA:
undetectable		 5ikmA-1k4yA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.88A 5kqrA-1k4yA:
undetectable		 5kqrA-1k4yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.83A 5kqsA-1k4yA:
undetectable		 5kqsA-1k4yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.82A 5m5bA-1k4yA:
undetectable		 5m5bA-1k4yA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		3 / 3 SER A 221
SER A 247
PHE A 101
 None
 0.89A 5mugA-1k4yA:
undetectable		 5mugA-1k4yA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.87A 5njvA-1k4yA:
undetectable		 5njvA-1k4yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.87A 5njvB-1k4yA:
undetectable		 5njvB-1k4yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.91A 5wz1B-1k4yA:
1.7		 5wz1B-1k4yA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.82A 5wz2A-1k4yA:
undetectable		 5wz2A-1k4yA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 248
GLY A 143
GLY A 141
GLY A 224
ASP A  90
 None
 0.85A 5wz2B-1k4yA:
undetectable		 5wz2B-1k4yA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1k4y LIVER
CARBOXYLESTERASE
(Oryctolagus
cuniculus) 		5 / 12 ASP A 182
GLY A 181
ASN A 259
ALA A 279
ASP A 193
 None
 1.17A 5x66A-1k4yA:
undetectable
5x66B-1k4yA:
undetectable		 5x66A-1k4yA:
20.11
5x66B-1k4yA:
20.11