SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 7 ALA A 159
ILE A 184
ILE A 176
ASP A 156
PHE A 155
 None
 1.45A 1upfB-1k5cA:
undetectable		 1upfB-1k5cA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		3 / 3 ASP A 139
ASP A  78
ASN A 171
 None
 0.75A 2bm9D-1k5cA:
undetectable		 2bm9D-1k5cA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 9 ALA A 273
GLY A 270
GLY A 301
ILE A 258
ALA A 229
 None
 0.91A 2z0yB-1k5cA:
undetectable		 2z0yB-1k5cA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 4 ARG A 231
ASP A 265
ASP A 264
PRO A 263
 GOL  A1001 (-3.9A)
None
GOL  A1001 (-2.8A)
None
 1.48A 3fgrB-1k5cA:
undetectable		 3fgrB-1k5cA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 9 GLY A 154
VAL A 138
ILE A 164
VAL A 157
VAL A 124
 None
 1.48A 3fhjD-1k5cA:
undetectable		 3fhjD-1k5cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 9 GLY A 154
VAL A 138
ILE A 164
VAL A 157
VAL A 124
 None
 1.48A 3fhjF-1k5cA:
undetectable		 3fhjF-1k5cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 9 GLY A 154
VAL A 138
ILE A 164
VAL A 157
VAL A 124
 None
 1.42A 3fi0K-1k5cA:
undetectable		 3fi0K-1k5cA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 8 SER A 198
ASN A 179
GLN A 120
ASP A 173
 None
 1.25A 3n66B-1k5cA:
0.0		 3n66B-1k5cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 8 LEU A 257
ALA A 319
THR A 294
GLY A 267
 None
None
None
GOL  A1001 ( 3.8A)
 0.92A 3ny4A-1k5cA:
undetectable		 3ny4A-1k5cA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 5 VAL A  34
PHE A  70
ILE A 103
PHE A 112
 None
 1.09A 3owxB-1k5cA:
undetectable		 3owxB-1k5cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 10 PHE A  77
PHE A  51
PHE A  61
ILE A 136
PHE A 112
 None
 1.25A 3t3qA-1k5cA:
undetectable		 3t3qA-1k5cA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 10 PHE A  77
PHE A  51
PHE A  61
ILE A 136
PHE A 112
 None
 1.23A 3t3qB-1k5cA:
undetectable		 3t3qB-1k5cA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 10 PHE A  77
PHE A  51
PHE A  61
ILE A 136
PHE A 112
 None
 1.27A 3t3qC-1k5cA:
0.0		 3t3qC-1k5cA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 10 PHE A  77
PHE A  51
PHE A  61
ILE A 136
PHE A 112
 None
 1.22A 3t3qD-1k5cA:
undetectable		 3t3qD-1k5cA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 5 ALA A 177
ILE A 202
LYS A 228
ASN A 179
 None
 1.17A 4g19A-1k5cA:
undetectable		 4g19A-1k5cA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 7 SER A 198
ASN A 179
GLN A 120
ASP A 173
 None
 1.30A 4kcnB-1k5cA:
0.0		 4kcnB-1k5cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 12 ASP A 153
ASP A 174
ASP A 156
ALA A 119
HIS A 150
 None
 1.07A 4wh5A-1k5cA:
undetectable		 4wh5A-1k5cA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 7 VAL A 162
ILE A 164
PHE A 155
VAL A 124
 None
 0.73A 5bmvC-1k5cA:
undetectable		 5bmvC-1k5cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 7 VAL A 162
ILE A 164
PHE A 155
VAL A 157
 None
 0.66A 5bmvC-1k5cA:
undetectable		 5bmvC-1k5cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 12 VAL A 162
ILE A 164
PHE A 155
VAL A 124
GLY A 125
 None
 0.82A 5j2tC-1k5cA:
undetectable		 5j2tC-1k5cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 6 PHE A 280
ASN A 279
TRP A 309
GLY A 331
 None
 1.11A 5o4yA-1k5cA:
undetectable		 5o4yA-1k5cA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		5 / 10 ALA A  11
LEU A  35
VAL A  34
LEU A  22
ILE A  49
 None
 1.07A 5v02B-1k5cA:
undetectable
5v02R-1k5cA:
undetectable		 5v02B-1k5cA:
12.84
5v02R-1k5cA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 8 SER A 198
ASN A 179
GLN A 120
ASP A 173
 None
 1.24A 5vunA-1k5cA:
0.0		 5vunA-1k5cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1k5c ENDOPOLYGALACTURONAS
E
(Chondrostereum
purpureum) 		4 / 8 SER A 198
ASN A 179
GLN A 120
ASP A 173
 None
 1.29A 5vunB-1k5cA:
undetectable		 5vunB-1k5cA:
18.89