SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M7T_A_SAMA503_0 (BTRN)	1k5d	RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN (Homo sapiens)	5 / 11	THR B 124 HIS B 102 LEU B 138 LEU B 55 ARG B 70	THR B 124 ( 0.8A) HIS B 102 ( 1.0A) LEU B 138 ( 0.6A) LEU B 55 ( 0.6A) ARG B 70 ( 0.6A)	1.46A	4m7tA-1k5dB: undetectable	4m7tA-1k5dB: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TL8_A_X2NA502_1 (PROTEIN CYP51)	1k5d	RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN (Homo sapiens)	5 / 12	PHE B 142 ALA B 148 ALA B 85 MET B 90 THR B 153	PHE B 142 ( 1.3A) ALA B 148 ( 0.0A) ALA B 85 ( 0.0A) MET B 90 ( 0.0A) THR B 153 ( 0.8A)	1.25A	5tl8A-1k5dB: undetectable	5tl8A-1k5dB: 17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F6J_D_ACTD404_0 (L-LYSINE 3-HYDROXYLASE)	1k5d	RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN (Homo sapiens)	4 / 6	GLU B 136 TRP B 122 HIS B 102 ALA B 100	GLU B 136 ( 0.5A) TRP B 122 ( 0.5A) HIS B 102 ( 1.0A) ALA B 100 ( 0.0A)	1.39A	6f6jC-1k5dB: 0.0 6f6jD-1k5dB: 0.0	6f6jC-1k5dB: 19.34 6f6jD-1k5dB: 19.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4M7T_A_SAMA503_0","BTRN","1k5d","RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN","Homo sapiens",5,"THR B 124;HIS B 102;LEU B 138;LEU B  55;ARG B  70","THR B 124 ( 0.8A);HIS B 102 ( 1.0A);LEU B 138 ( 0.6A);LEU B  55 ( 0.6A);ARG B  70 ( 0.6A)","1.46A","4m7tA-1k5dB:undetectable","4m7tA-1k5dB:22.06"],["5TL8_A_X2NA502_1","PROTEIN CYP51","1k5d","RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN","Homo sapiens",5,"PHE B 142;ALA B 148;ALA B  85;MET B  90;THR B 153","PHE B 142 ( 1.3A);ALA B 148 ( 0.0A);ALA B  85 ( 0.0A);MET B  90 ( 0.0A);THR B 153 ( 0.8A)","1.25A","5tl8A-1k5dB:undetectable","5tl8A-1k5dB:17.67"],["6F6J_D_ACTD404_0","L-LYSINE 3-HYDROXYLASE","1k5d","RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN","Homo sapiens",4,"GLU B 136;TRP B 122;HIS B 102;ALA B 100","GLU B 136 ( 0.5A);TRP B 122 ( 0.5A);HIS B 102 ( 1.0A);ALA B 100 ( 0.0A)","1.39A","6f6jC-1k5dB:0.0;6f6jD-1k5dB:0.0","6f6jC-1k5dB:19.34;6f6jD-1k5dB:19.34"]]