SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 THR A  80
ILE A  29
GLY A  28
GLY A  60
ALA A  51
 None
 1.03A 1nv8A-1k6dA:
2.6		 1nv8A-1k6dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 THR A  80
ILE A  29
GLY A  28
GLY A  60
ALA A  51
 None
 0.99A 1nv8B-1k6dA:
2.7		 1nv8B-1k6dA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 VAL A  98
ILE A 107
ILE A  50
VAL A  70
ILE A  61
 None
 1.31A 1r5lA-1k6dA:
1.7		 1r5lA-1k6dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 GLY A 122
GLY A 101
GLN A 106
PHE A 117
 None
 1.03A 2qx6A-1k6dA:
2.5
2qx6B-1k6dA:
undetectable		 2qx6A-1k6dA:
23.20
2qx6B-1k6dA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 9 ALA A  55
ASP A  53
VAL A  73
MET A  88
LEU A  97
 None
 1.23A 3s7sA-1k6dA:
0.0		 3s7sA-1k6dA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 THR A  31
VAL A  23
GLU A 188
 None
 0.47A 3v4tA-1k6dA:
0.0
3v4tD-1k6dA:
0.0		 3v4tA-1k6dA:
22.51
3v4tD-1k6dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 ILE A  61
ILE A  65
VAL A  95
GLY A  85
 None
 0.78A 4ac9C-1k6dA:
2.3		 4ac9C-1k6dA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A 107
GLY A  24
ILE A 154
ALA A 152
PHE A  26
 None
 1.07A 4kicB-1k6dA:
2.2		 4kicB-1k6dA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A  25
GLY A  30
ASN A  52
ILE A  21
THR A  20
 None
 1.00A 4n49A-1k6dA:
undetectable		 4n49A-1k6dA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 THR A  31
GLY A  25
PHE A  26
ILE A 104
 None
 0.91A 5kmfA-1k6dA:
undetectable
5kmfC-1k6dA:
undetectable		 5kmfA-1k6dA:
22.11
5kmfC-1k6dA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 PHE A  15
LEU A   8
ALA A  11
ARG A  34
LEU A  49
 None
 1.26A 5ljbA-1k6dA:
undetectable		 5ljbA-1k6dA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 PHE A  15
LEU A   8
ALA A  11
ARG A  34
LEU A  49
 None
 1.25A 5ljcA-1k6dA:
undetectable		 5ljcA-1k6dA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 PRO A 206
GLY A 207
LEU A 153
ASP A 211
PHE A  14
 None
None
None
MG  A 304 ( 4.1A)
None
 1.28A 5yn6A-1k6dA:
0.0		 5yn6A-1k6dA:
24.07