SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 7 LEU A 141
ILE A 142
PHE A 145
ALA A 108
 None
 0.95A 1oniB-1k6mA:
0.0
1oniC-1k6mA:
0.0		 1oniB-1k6mA:
14.91
1oniC-1k6mA:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		12 / 12 PRO A  50
LYS A  54
THR A  55
ASN A  76
GLY A  78
ARG A  82
PHE A  93
ARG A 104
ALA A 131
THR A 132
ARG A 195
TYR A 199
 None
AGS  A 503 (-2.9A)
AGS  A 503 (-3.3A)
AGS  A 503 ( 4.3A)
None
None
None
None
None
None
None
None
 0.53A 2axnA-1k6mA:
50.8		 2axnA-1k6mA:
64.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 6 LEU A 370
VAL A 466
ILE A 269
MET A 396
 None
 1.24A 2hyyB-1k6mA:
undetectable		 2hyyB-1k6mA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 7 ILE A  45
ILE A 219
LEU A 243
ILE A 217
 None
AGS  A 503 ( 4.3A)
None
None
 0.85A 2q83A-1k6mA:
undetectable		 2q83A-1k6mA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 5 LEU A  65
GLN A 236
THR A 239
LEU A 119
 None
 1.16A 3ce6D-1k6mA:
undetectable		 3ce6D-1k6mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 7 LEU A 370
VAL A 466
ILE A 269
MET A 396
 None
 1.27A 3ik3A-1k6mA:
undetectable		 3ik3A-1k6mA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 6 LEU A 370
VAL A 466
ILE A 269
MET A 396
 None
 1.21A 3k5vB-1k6mA:
undetectable		 3k5vB-1k6mA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 6 GLU A 365
ILE A 328
GLU A 327
ASN A 326
 None
None
PO4  A 501 (-3.9A)
None
 0.98A 3pgyA-1k6mA:
undetectable
3pgyB-1k6mA:
2.2		 3pgyA-1k6mA:
22.06
3pgyB-1k6mA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 290
VAL A 421
ILE A 253
LEU A 381
VAL A 377
 None
 1.08A 3w68C-1k6mA:
undetectable		 3w68C-1k6mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		4 / 5 TYR A  80
THR A  70
LEU A  65
THR A  55
 None
None
None
AGS  A 503 (-3.3A)
 1.44A 4mbsB-1k6mA:
0.0		 4mbsB-1k6mA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		5 / 12 SER A 273
ALA A 330
THR A 337
THR A 445
ARG A 257
 None
None
None
None
PO4  A 501 (-3.7A)
 1.31A 4z7fC-1k6mA:
0.1		 4z7fC-1k6mA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		5 / 10 TYR A  56
ILE A 246
ILE A 156
ILE A 219
ILE A 217
 AGS  A 503 (-3.3A)
None
None
AGS  A 503 ( 4.3A)
None
 1.01A 5murE-1k6mA:
0.0		 5murE-1k6mA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		5 / 6 LEU A 298
VAL A 317
LEU A 388
LEU A 325
GLU A 380
 None
 1.31A 5tudD-1k6mA:
undetectable		 5tudD-1k6mA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		3 / 3 LEU A 422
THR A 445
ASN A 444
 None
 0.66A 6baaE-1k6mA:
2.0		 6baaE-1k6mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		3 / 3 LEU A 422
THR A 445
ASN A 444
 None
 0.67A 6baaF-1k6mA:
2.9		 6baaF-1k6mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		3 / 3 LEU A 422
THR A 445
ASN A 444
 None
 0.67A 6baaG-1k6mA:
undetectable		 6baaG-1k6mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		3 / 3 LEU A 422
THR A 445
ASN A 444
 None
 0.67A 6baaH-1k6mA:
2.9		 6baaH-1k6mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A  82
LYS A 174
TYR A 180
 None
AGS  A 503 (-2.9A)
None
 1.26A 6gnaA-1k6mA:
0.4		 6gnaA-1k6mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A  82
LYS A 174
TYR A 180
 None
AGS  A 503 (-2.9A)
None
 1.26A 6gnbA-1k6mA:
0.4		 6gnbA-1k6mA:
22.25