SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1k6y INTEGRASE
(Human
immunodeficiency
virus
1) 		6 / 11 ALA A  76
THR A 115
VAL A 126
ALA A 129
ALA A 133
LEU A 104
 None
 1.47A 1jinA-1k6yA:
0.0		 1jinA-1k6yA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1k6y INTEGRASE
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.76A 1vptA-1k6yA:
undetectable		 1vptA-1k6yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1k6y INTEGRASE
(Human
immunodeficiency
virus
1) 		4 / 8 THR A 115
GLN A 137
ASP A 116
CYH A  65
 None
 1.30A 2xz5A-1k6yA:
0.0
2xz5C-1k6yA:
0.0		 2xz5A-1k6yA:
19.31
2xz5C-1k6yA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1k6y INTEGRASE
(Human
immunodeficiency
virus
1) 		5 / 12 VAL A 165
ALA A 169
ILE A  73
LEU A 158
ILE A 162
 None
 1.02A 3clbC-1k6yA:
undetectable		 3clbC-1k6yA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1k6y INTEGRASE
(Human
immunodeficiency
virus
1) 		4 / 8 GLY A  94
LEU A  63
ASN A 120
PHE A 121
 None
 1.23A 4m5mA-1k6yA:
0.7		 4m5mA-1k6yA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 1k6y INTEGRASE
(Human
immunodeficiency
virus
1) 		4 / 5 ASN A  27
LEU A  28
SER A  24
ASN A  18
 None
 1.23A 4n09C-1k6yA:
undetectable		 4n09C-1k6yA:
19.15