SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_D_BEZD1162_0
(PEROXIREDOXIN 5)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		5 / 9 GLY A 238
CYH A 239
LEU A 224
PHE A 225
THR A 179
 None
 1.39A 1h4oD-1k77A:
1.6		 1h4oD-1k77A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		5 / 10 ILE A 164
ALA A 120
PHE A 122
ILE A  87
ILE A 126
 None
 1.20A 1j3jA-1k77A:
0.0		 1j3jA-1k77A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		4 / 6 TYR A 233
GLU A  33
ILE A 175
GLY A 198
 None
 1.14A 1maaB-1k77A:
1.1
1maaD-1k77A:
undetectable		 1maaB-1k77A:
19.85
1maaD-1k77A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		5 / 11 ILE A 164
ALA A 120
PHE A 122
ILE A  87
ILE A 126
 None
 1.12A 2blaA-1k77A:
undetectable		 2blaA-1k77A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		3 / 3 ASP A 131
ARG A 127
ALA A 130
 None
 0.69A 3mbgC-1k77A:
0.0		 3mbgC-1k77A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		5 / 10 ILE A 164
ALA A 120
PHE A 122
ILE A  87
ILE A 126
 None
 1.22A 3qgtA-1k77A:
undetectable		 3qgtA-1k77A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		4 / 8 TYR A 159
TYR A 196
VAL A 203
ILE A 175
 None
 0.95A 4aftD-1k77A:
0.0
4aftE-1k77A:
0.0		 4aftD-1k77A:
21.77
4aftE-1k77A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		3 / 3 HIS A 202
GLU A 143
ASN A  60
 None
MG  A 300 ( 2.7A)
None
 0.86A 4bupB-1k77A:
0.0		 4bupB-1k77A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		6 / 12 LEU A 145
PHE A 155
GLY A 107
ALA A  75
ILE A 164
VAL A 104
 FMT  A 304 ( 4.7A)
None
None
None
None
None
 1.36A 4nkxB-1k77A:
0.0		 4nkxB-1k77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		4 / 6 HIS A 103
TYR A 153
PHE A 122
ASN A 125
 None
 1.37A 4o7gB-1k77A:
undetectable		 4o7gB-1k77A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		5 / 11 GLY A 238
MET A  11
ILE A 205
GLY A 235
PHE A  29
 None
 1.13A 4qoiA-1k77A:
undetectable
4qoiB-1k77A:
undetectable		 4qoiA-1k77A:
21.45
4qoiB-1k77A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		3 / 3 HIS A 202
GLU A 143
ASN A  60
 None
MG  A 300 ( 2.7A)
None
 0.79A 5wbvA-1k77A:
undetectable		 5wbvA-1k77A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		3 / 3 HIS A 202
GLU A 143
ASN A  60
 None
MG  A 300 ( 2.7A)
None
 0.79A 5wbvB-1k77A:
undetectable		 5wbvB-1k77A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1k77 HYPOTHETICAL PROTEIN
YGBM
(Escherichia
coli) 		4 / 6 GLN A 158
VAL A 165
LEU A 189
ARG A 194
 None
 1.16A 6brdB-1k77A:
0.0		 6brdB-1k77A:
15.77