SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k7h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 7 THR A  43
THR A 354
GLY A  36
ASP A  37
 None
None
None
ZN  A 478 ( 2.1A)
 0.99A 1bu5A-1k7hA:
undetectable		 1bu5A-1k7hA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 8 THR A  43
THR A 354
GLY A  36
ASP A  37
 None
None
None
ZN  A 478 ( 2.1A)
 1.02A 1bu5B-1k7hA:
undetectable		 1bu5B-1k7hA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ILE A 128
LEU A  35
SER A  74
ILE A 439
LEU A 352
 None
 1.08A 1ddsB-1k7hA:
2.2		 1ddsB-1k7hA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 5 ASP A 315
HIS A 319
HIS A 357
HIS A 432
 ZN  A 477 (-2.1A)
ZN  A 477 (-3.2A)
ZN  A 478 (-3.1A)
ZN  A 477 (-3.2A)
 0.49A 1ei6A-1k7hA:
15.1		 1ei6A-1k7hA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 8 ASP A  37
ASP A 315
HIS A 319
HIS A 357
HIS A 432
 ZN  A 478 ( 2.1A)
ZN  A 477 (-2.1A)
ZN  A 477 (-3.2A)
ZN  A 478 (-3.1A)
ZN  A 477 (-3.2A)
 0.48A 1ei6C-1k7hA:
15.2		 1ei6C-1k7hA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 8 GLU A 165
ALA A 157
GLU A 310
ALA A  90
 None
None
ZN  A 479 (-2.5A)
None
 0.94A 1ie4B-1k7hA:
undetectable
1ie4D-1k7hA:
undetectable		 1ie4B-1k7hA:
13.82
1ie4D-1k7hA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 7 LEU A  94
TYR A 156
GLY A 105
TYR A  93
 None
 1.02A 1lweA-1k7hA:
0.0		 1lweA-1k7hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 ALA A 355
VAL A 353
TRP A 440
 None
 0.92A 1magA-1k7hA:
undetectable		 1magA-1k7hA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 ALA A 355
VAL A 353
TRP A 440
 None
 0.92A 1magB-1k7hA:
undetectable		 1magB-1k7hA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 11 LEU A 264
VAL A 256
ILE A 258
LEU A 307
LEU A 298
 None
 1.21A 1mrqA-1k7hA:
undetectable		 1mrqA-1k7hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 9 GLY A 206
GLU A 210
GLY A 221
GLY A 226
ASP A 225
 None
 1.11A 1mxdA-1k7hA:
0.0		 1mxdA-1k7hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 11 GLY A 206
GLU A 210
GLY A 221
GLY A 226
ASP A 225
 None
 1.12A 1mxgA-1k7hA:
undetectable		 1mxgA-1k7hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 ALA A 355
VAL A 353
TRP A  65
 None
 0.82A 1nt6A-1k7hA:
undetectable		 1nt6A-1k7hA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 ALA A 355
VAL A 353
TRP A  65
 None
 0.82A 1nt6B-1k7hA:
undetectable		 1nt6B-1k7hA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 10 ALA A 422
LYS A 415
ILE A 373
ARG A 324
ILE A 323
 None
 1.16A 1rb3A-1k7hA:
2.2		 1rb3A-1k7hA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 10 ILE A 350
ALA A  28
GLN A  27
ARG A 137
ILE A 458
 None
 1.13A 2aclC-1k7hA:
undetectable		 2aclC-1k7hA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 11 ILE A 350
ALA A  28
GLN A  27
ARG A 137
ILE A 458
 None
 1.12A 2aclE-1k7hA:
undetectable		 2aclE-1k7hA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ARG A 190
GLY A 154
ALA A 153
VAL A 103
ILE A 183
 None
 1.10A 2avsB-1k7hA:
undetectable		 2avsB-1k7hA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 7 ARG A 162
ASP A 169
ARG A 146
ASP A 163
 None
None
SO4  A 481 (-3.1A)
None
 1.15A 2e5dA-1k7hA:
0.2
2e5dB-1k7hA:
0.5		 2e5dA-1k7hA:
20.83
2e5dB-1k7hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 7 ASP A 163
ARG A 162
ASP A 169
ARG A 146
 None
None
None
SO4  A 481 (-3.1A)
 1.05A 2e5dA-1k7hA:
undetectable
2e5dB-1k7hA:
undetectable		 2e5dA-1k7hA:
20.83
2e5dB-1k7hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 7 PHE A 268
LEU A 253
LEU A 254
ARG A 279
 None
 1.01A 2jn3A-1k7hA:
undetectable		 2jn3A-1k7hA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 LEU A 448
TYR A 464
GLY A 471
 None
 0.64A 2ocuA-1k7hA:
undetectable		 2ocuA-1k7hA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 10 HIS A 357
ALA A  88
ASN A  78
ALA A  87
SER A  86
 ZN  A 478 (-3.1A)
None
None
None
ZN  A 478 (-1.7A)
 1.36A 2r2vC-1k7hA:
0.0
2r2vF-1k7hA:
0.0
2r2vG-1k7hA:
0.0		 2r2vC-1k7hA:
6.78
2r2vF-1k7hA:
6.78
2r2vG-1k7hA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ALA A 336
LEU A 331
MET A  39
ILE A 314
GLY A 312
 None
None
None
None
ZN  A 479 ( 4.5A)
 1.04A 2yjaB-1k7hA:
0.0		 2yjaB-1k7hA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 ASP A 251
THR A 271
GLU A 216
 None
SO4  A 483 ( 4.5A)
None
 0.76A 2zifB-1k7hA:
undetectable		 2zifB-1k7hA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 HIS A 149
HIS A 316
HIS A 272
 ZN  A 479 (-3.1A)
None
SO4  A 481 ( 4.8A)
 0.74A 3ag4A-1k7hA:
undetectable		 3ag4A-1k7hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 HIS A 149
HIS A 316
HIS A 272
 ZN  A 479 (-3.1A)
None
SO4  A 481 ( 4.8A)
 0.75A 3ag4N-1k7hA:
0.0		 3ag4N-1k7hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 5 TYR A 421
ALA A  46
ALA A 377
TYR A 366
 None
 1.19A 3d91A-1k7hA:
0.0		 3d91A-1k7hA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 10 ILE A 350
ALA A  28
GLN A  27
ARG A 137
ILE A 458
 None
 1.13A 3falA-1k7hA:
undetectable		 3falA-1k7hA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 LEU A 307
SER A  64
VAL A 309
ILE A 295
THR A 344
 None
 1.38A 3frqA-1k7hA:
undetectable		 3frqA-1k7hA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 TYR A 392
ILE A  63
ILE A 314
MET A  39
HIS A 318
 None
 1.44A 3g8iA-1k7hA:
undetectable		 3g8iA-1k7hA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ILE A 128
LEU A  35
SER A  74
ILE A 439
LEU A 352
 None
 1.20A 3ia4D-1k7hA:
undetectable		 3ia4D-1k7hA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 4 GLY A 201
VAL A 147
GLY A 140
THR A 139
 None
 0.89A 3ib2A-1k7hA:
0.0		 3ib2A-1k7hA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 8 LEU A 273
ARG A 279
ALA A 281
GLY A 266
 None
 0.84A 3ny4A-1k7hA:
undetectable		 3ny4A-1k7hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		6 / 12 ILE A 350
ALA A  28
GLN A  27
ARG A 137
ILE A 458
LEU A 448
 None
 1.31A 3oapA-1k7hA:
undetectable		 3oapA-1k7hA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 10 ILE A 128
PHE A  33
SER A  74
ILE A 439
THR A 155
 None
 1.40A 3qg2A-1k7hA:
2.9		 3qg2A-1k7hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 10 ILE A 128
PHE A  33
SER A  74
ILE A 439
THR A 155
 None
 1.39A 3um5A-1k7hA:
2.6		 3um5A-1k7hA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 6 GLU A 216
ASP A 251
ASP A 274
GLU A 282
 None
None
SO4  A 483 (-4.5A)
None
 1.08A 3vywA-1k7hA:
undetectable		 3vywA-1k7hA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_1
(MNMC2)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 4 GLU A 216
ASP A 251
ASP A 274
GLU A 282
 None
None
SO4  A 483 (-4.5A)
None
 1.00A 3vywB-1k7hA:
0.0		 3vywB-1k7hA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 6 GLU A 216
ASP A 251
ASP A 274
GLU A 282
 None
None
SO4  A 483 (-4.5A)
None
 1.06A 3vywC-1k7hA:
undetectable		 3vywC-1k7hA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 5 GLU A 216
ASP A 251
ASP A 274
GLU A 282
 None
None
SO4  A 483 (-4.5A)
None
 1.05A 3vywD-1k7hA:
2.3		 3vywD-1k7hA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 6 THR A 271
GLY A 203
ARG A 162
LEU A 273
 SO4  A 483 ( 4.5A)
None
None
None
 0.97A 4ac9C-1k7hA:
undetectable		 4ac9C-1k7hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 6 THR A 271
GLY A 203
ARG A 162
LEU A 273
 SO4  A 483 ( 4.5A)
None
None
None
 0.94A 4acaC-1k7hA:
undetectable		 4acaC-1k7hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 6 THR A 271
GLY A 203
ARG A 162
LEU A 273
 SO4  A 483 ( 4.5A)
None
None
None
 0.93A 4acbC-1k7hA:
undetectable		 4acbC-1k7hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 7 GLY A 311
ASP A  37
GLY A  36
HIS A 357
 None
ZN  A 478 ( 2.1A)
None
ZN  A 478 (-3.1A)
 0.86A 4c5nA-1k7hA:
undetectable		 4c5nA-1k7hA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 8 GLY A 311
ASP A  37
GLY A  36
HIS A 357
 None
ZN  A 478 ( 2.1A)
None
ZN  A 478 (-3.1A)
 0.85A 4c5nC-1k7hA:
undetectable		 4c5nC-1k7hA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ILE A 128
LEU A  35
SER A  74
ILE A 439
LEU A 352
 None
 1.14A 4gh8A-1k7hA:
2.1		 4gh8A-1k7hA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 7 HIS A 319
ASP A 315
HIS A 359
VAL A  83
 ZN  A 477 (-3.2A)
ZN  A 477 (-2.1A)
None
None
 1.13A 4hvrA-1k7hA:
undetectable		 4hvrA-1k7hA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 8 LEU A 352
SER A  64
GLY A 311
MET A 333
 None
 0.97A 4klrB-1k7hA:
undetectable		 4klrB-1k7hA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 11 ILE A 128
PHE A  33
SER A  74
ILE A 439
THR A 155
 None
 1.34A 4p68A-1k7hA:
2.1		 4p68A-1k7hA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ASP A 225
GLU A 165
GLY A 221
ALA A 212
LEU A 229
 None
 1.29A 4retA-1k7hA:
3.3		 4retA-1k7hA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ASP A 225
GLU A 165
GLY A 221
ALA A 212
LEU A 229
 None
 1.28A 4retC-1k7hA:
0.0		 4retC-1k7hA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 4 ASN A  78
SER A  86
ALA A  88
VAL A 103
 None
ZN  A 478 (-1.7A)
None
None
 1.31A 4x1kC-1k7hA:
undetectable		 4x1kC-1k7hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ILE A 314
ALA A 355
LEU A  41
ILE A  63
ARG A  48
 None
 1.07A 4x5jA-1k7hA:
2.1		 4x5jA-1k7hA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 8 ASP A 356
ASP A  37
ILE A 104
ASP A  85
 ZN  A 478 (-2.3A)
ZN  A 478 ( 2.1A)
None
None
 1.01A 4xjeA-1k7hA:
0.0		 4xjeA-1k7hA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 5 ARG A 313
GLY A 311
GLU A 329
SER A  89
 SO4  A 483 (-2.9A)
None
None
None
 1.15A 4z3oA-1k7hA:
undetectable
4z3oB-1k7hA:
undetectable		 4z3oA-1k7hA:
21.35
4z3oB-1k7hA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 11 SER A  89
THR A  76
ALA A 430
ASP A  37
GLY A  36
 None
None
None
ZN  A 478 ( 2.1A)
None
 1.22A 4zjoD-1k7hA:
0.0		 4zjoD-1k7hA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 5 SER A  42
GLY A  36
THR A 145
GLU A 310
 None
None
ZN  A 479 ( 4.6A)
ZN  A 479 (-2.5A)
 1.16A 5btiA-1k7hA:
undetectable
5btiB-1k7hA:
0.6		 5btiA-1k7hA:
22.68
5btiB-1k7hA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 5 SER A  42
GLY A  36
THR A 145
GLU A 310
 None
None
ZN  A 479 ( 4.6A)
ZN  A 479 (-2.5A)
 1.15A 5btiC-1k7hA:
undetectable
5btiD-1k7hA:
undetectable		 5btiC-1k7hA:
22.68
5btiD-1k7hA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ALA A 336
LEU A 331
MET A  39
ILE A 314
GLY A 312
 None
None
None
None
ZN  A 479 ( 4.5A)
 1.04A 5gs4A-1k7hA:
undetectable		 5gs4A-1k7hA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ILE A 128
LEU A  35
SER A  74
ILE A 439
LEU A 352
 None
 1.08A 5hi6B-1k7hA:
2.5		 5hi6B-1k7hA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 7 HIS A 158
ILE A 104
VAL A 103
GLN A 118
 None
 1.12A 5kkzM-1k7hA:
0.0
5kkzO-1k7hA:
undetectable		 5kkzM-1k7hA:
17.88
5kkzO-1k7hA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 10 VAL A 159
ASP A 161
LEU A 187
ALA A 157
THR A 143
 None
 1.22A 5m5cE-1k7hA:
undetectable		 5m5cE-1k7hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 7 ASP A  37
GLY A 312
ASP A 356
HIS A 319
ASP A 315
 ZN  A 478 ( 2.1A)
ZN  A 479 ( 4.5A)
ZN  A 478 (-2.3A)
ZN  A 477 (-3.2A)
ZN  A 477 (-2.1A)
 1.46A 5nnwD-1k7hA:
0.0		 5nnwD-1k7hA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		4 / 6 LEU A 331
ARG A 313
THR A 278
LEU A 277
 None
SO4  A 483 (-2.9A)
None
None
 1.06A 5x1fA-1k7hA:
0.0
5x1fJ-1k7hA:
0.0		 5x1fA-1k7hA:
22.22
5x1fJ-1k7hA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 THR A 151
GLU A 310
HIS A 316
 ZN  A 479 (-3.1A)
ZN  A 479 (-2.5A)
None
 0.90A 5xiqB-1k7hA:
undetectable		 5xiqB-1k7hA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 12 ILE A 314
ALA A 355
LEU A  41
ILE A  63
ARG A  48
 None
 1.15A 5z6fA-1k7hA:
undetectable		 5z6fA-1k7hA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		3 / 3 HIS A 149
HIS A 316
HIS A 272
 ZN  A 479 (-3.1A)
None
SO4  A 481 ( 4.8A)
 0.74A 6giqa-1k7hA:
undetectable		 6giqa-1k7hA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1k7h ALKALINE PHOSPHATASE
(Pandalus
borealis) 		5 / 11 ILE A 314
HIS A 357
HIS A 149
SER A  89
ALA A 355
 None
ZN  A 478 (-3.1A)
ZN  A 479 (-3.1A)
None
None
 1.13A 6ieyA-1k7hA:
undetectable
6ieyB-1k7hA:
undetectable		 6ieyA-1k7hA:
21.79
6ieyB-1k7hA:
21.79