SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 GLU A1123
ILE A1126
ARG A1094
 None
None
B12  A1248 ( 4.9A)
 0.82A 1cd2A-1k7yA:
0.0		 1cd2A-1k7yA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 8 ARG A 876
GLY A 802
ILE A 801
VAL A 867
 None
B12  A1248 (-3.5A)
None
None
 0.80A 1d4sB-1k7yA:
undetectable		 1d4sB-1k7yA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.32A 1dz8A-1k7yA:
0.0		 1dz8A-1k7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.35A 1dz8B-1k7yA:
undetectable		 1dz8B-1k7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.33A 1dz9B-1k7yA:
0.0		 1dz9B-1k7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.32A 1ikvA-1k7yA:
1.1		 1ikvA-1k7yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.38A 1ikwA-1k7yA:
1.0		 1ikwA-1k7yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
None
None
B12  A1248 (-4.9A)
None
 1.33A 1jhoA-1k7yA:
4.8		 1jhoA-1k7yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 8 THR A1161
GLY A 997
LEU A1067
SER A1176
GLY A1066
 None
None
None
B12  A1248 (-4.9A)
None
 1.33A 1jhqA-1k7yA:
4.6		 1jhqA-1k7yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.35A 1lw0A-1k7yA:
1.2		 1lw0A-1k7yA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.23A 1lwfA-1k7yA:
0.3		 1lwfA-1k7yA:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MSK_A_ACTA1302_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 4 GLN A 932
VAL A 934
ARG A1106
TYR A1111
 SO4  A 267 (-3.0A)
None
SO4  A 267 (-3.6A)
SO4  A 267 (-4.8A)
 1.18A 1mskA-1k7yA:
49.2		 1mskA-1k7yA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		10 / 10 ASP A 946
ARG A1094
GLU A1097
ARG A1134
PRO A1135
ALA A1136
TYR A1139
PRO A1140
ALA A1141
TYR A1189
 None
B12  A1248 ( 4.9A)
B12  A1248 ( 4.8A)
None
None
B12  A1248 (-3.6A)
B12  A1248 ( 3.8A)
B12  A1248 ( 4.6A)
None
None
 0.85A 1mskA-1k7yA:
49.2		 1mskA-1k7yA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 10 TYR A1181
LEU A1103
VAL A1063
THR A1161
VAL A1157
 None
 1.34A 1o76A-1k7yA:
0.0		 1o76A-1k7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A1112
VAL A 925
PRO A 924
 None
 0.82A 1rg1A-1k7yA:
undetectable		 1rg1A-1k7yA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 TRP A1112
VAL A 925
PRO A 924
 None
 0.83A 1rh0A-1k7yA:
2.0		 1rh0A-1k7yA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 GLU A 673
GLU A 676
LEU A 663
 None
 0.63A 1v8bA-1k7yA:
2.0		 1v8bA-1k7yA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 GLU A 673
GLU A 676
LEU A 663
 None
 0.63A 1v8bB-1k7yA:
6.0		 1v8bB-1k7yA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		6 / 11 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
VAL A1157
 None
 1.41A 2a1nA-1k7yA:
undetectable		 2a1nA-1k7yA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
ILE A1151
 None
 1.17A 2a1oB-1k7yA:
0.0		 2a1oB-1k7yA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A 896
ARG A 900
PRO A 899
 None
 1.09A 2wljA-1k7yA:
2.5		 2wljA-1k7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 MET A 783
VAL A 750
GLU A 787
 None
 0.72A 2x9gA-1k7yA:
8.0		 2x9gA-1k7yA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 8 VAL A 668
GLY A 700
LYS A 669
LYS A 726
 None
 0.94A 3bjwA-1k7yA:
0.0		 3bjwA-1k7yA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.32A 3lp1A-1k7yA:
1.1		 3lp1A-1k7yA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.34A 3qipA-1k7yA:
1.1		 3qipA-1k7yA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ASN A 912
ALA A1039
LYS A1035
 None
 0.99A 3runA-1k7yA:
0.0		 3runA-1k7yA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A1175
GLY A1066
LEU A 987
LEU A1095
ILE A 938
 B12  A1248 (-4.6A)
None
None
None
None
 1.11A 3wdmB-1k7yA:
4.5		 3wdmB-1k7yA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 8 ILE A 846
ILE A 832
VAL A 754
GLY A 805
 None
 0.75A 4ac9C-1k7yA:
2.7		 4ac9C-1k7yA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 8 ILE A 846
ILE A 832
VAL A 754
GLY A 805
 None
 0.71A 4acaC-1k7yA:
2.9		 4acaC-1k7yA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 8 ILE A 846
ILE A 832
VAL A 754
GLY A 805
 None
 0.71A 4acbC-1k7yA:
2.7		 4acbC-1k7yA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 6 GLY A1059
TYR A1111
ALA A1060
TYR A1181
 None
SO4  A 267 (-4.8A)
None
None
 0.99A 4ae1A-1k7yA:
undetectable		 4ae1A-1k7yA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 667
GLY A 700
ASN A 702
MET A 725
ALA A 728
 None
 1.26A 4eb4A-1k7yA:
undetectable		 4eb4A-1k7yA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 667
GLY A 700
ASN A 702
MET A 725
ALA A 728
 None
 1.26A 4eb4B-1k7yA:
undetectable		 4eb4B-1k7yA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A1108
HIS A1104
TYR A1130
 None
 1.32A 4fu9A-1k7yA:
0.0		 4fu9A-1k7yA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 5 ILE A 832
SER A 838
HIS A 841
ASP A 757
 None
 1.16A 4rzvB-1k7yA:
0.0		 4rzvB-1k7yA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 6 ARG A 910
ASP A1202
VAL A1007
ASP A1010
 None
 1.26A 4xqeA-1k7yA:
3.8		 4xqeA-1k7yA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 6 ARG A 910
ASP A1202
VAL A1007
ASP A1010
 None
 1.25A 4xqeB-1k7yA:
3.8		 4xqeB-1k7yA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ALA A 728
TYR A 731
PRO A 689
 None
 0.68A 4zdyA-1k7yA:
0.0		 4zdyA-1k7yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 8 PRO A1135
PHE A1182
SER A1183
TYR A1114
 None
 1.07A 5amiB-1k7yA:
undetectable		 5amiB-1k7yA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 7 ALA A 909
ASP A1010
THR A1146
GLU A1147
 None
 0.78A 5bs8A-1k7yA:
0.0
5bs8C-1k7yA:
0.0
5bs8D-1k7yA:
4.7		 5bs8A-1k7yA:
24.13
5bs8C-1k7yA:
24.13
5bs8D-1k7yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 7 ALA A 909
ASP A1010
THR A1146
GLU A1147
 None
 0.72A 5btgA-1k7yA:
0.0
5btgC-1k7yA:
0.0
5btgD-1k7yA:
4.2		 5btgA-1k7yA:
24.13
5btgC-1k7yA:
24.13
5btgD-1k7yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
GLY A 997
THR A1161
 None
 1.34A 5cp4A-1k7yA:
0.0		 5cp4A-1k7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 9 TYR A1181
LEU A1103
VAL A1063
THR A1161
VAL A1157
 None
 1.42A 5cp4A-1k7yA:
0.0		 5cp4A-1k7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 4 ASN A1129
ILE A 945
TYR A 944
PHE A1061
 None
 1.43A 5igvA-1k7yA:
0.0		 5igvA-1k7yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 VAL A 769
SER A 955
MET A1087
 None
B12  A1248 ( 4.5A)
None
 0.93A 5ikqA-1k7yA:
0.0		 5ikqA-1k7yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 6 TYR A1102
LEU A1095
GLY A1065
PHE A1099
 None
 1.04A 5nooC-1k7yA:
undetectable		 5nooC-1k7yA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 8 LEU A 831
ALA A 793
VAL A 866
MET A 821
 B12  A1248 (-4.3A)
None
None
None
 1.02A 5nu7A-1k7yA:
undetectable		 5nu7A-1k7yA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A1081
ASN A1084
ASP A 979
 None
SO4  A 251 ( 3.5A)
SO4  A 251 ( 3.9A)
 0.83A 5vopA-1k7yA:
undetectable		 5vopA-1k7yA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A1081
ASN A1084
ASP A 979
 None
SO4  A 251 ( 3.5A)
SO4  A 251 ( 3.9A)
 0.85A 5vopB-1k7yA:
2.6		 5vopB-1k7yA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		11 / 11 ASP A 946
PRO A 949
ARG A1094
GLU A1097
ARG A1134
PRO A1135
ALA A1136
TYR A1139
PRO A1140
ALA A1141
TYR A1189
 None
None
B12  A1248 ( 4.9A)
B12  A1248 ( 4.8A)
None
None
B12  A1248 (-3.6A)
B12  A1248 ( 3.8A)
B12  A1248 ( 4.6A)
None
None
 0.84A 6bm5A-1k7yA:
48.9		 6bm5A-1k7yA:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		6 / 11 ASP A 946
PRO A 949
ARG A1094
TYR A1139
PRO A1140
ALA A1191
 None
None
B12  A1248 ( 4.9A)
B12  A1248 ( 3.8A)
B12  A1248 ( 4.6A)
None
 1.37A 6bm5A-1k7yA:
48.9		 6bm5A-1k7yA:
99.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.35A 6bsgA-1k7yA:
1.4		 6bsgA-1k7yA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1k7y METHIONINE SYNTHASE
(Escherichia
coli) 		4 / 6 GLN A1199
GLU A 907
ALA A 909
GLN A1032
 None
 1.36A 6f6jC-1k7yA:
0.0
6f6jD-1k7yA:
0.2		 6f6jC-1k7yA:
22.05
6f6jD-1k7yA:
22.05