SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 1k86 CASPASE-7
(Homo
sapiens) 		4 / 8 CYH A 186
PHE A  78
ARG A 233
THR A  90
 None
 0.66A 1h4oB-1k86A:
undetectable		 1h4oB-1k86A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 1k86 CASPASE-7
(Homo
sapiens) 		4 / 8 CYH A 186
PHE A  78
ARG A 233
THR A  90
 None
 0.71A 1oc3A-1k86A:
undetectable		 1oc3A-1k86A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 12 LEU A  97
PHE A 101
SER A 239
PRO A 289
VAL A 269
 None
 1.10A 2hrcA-1k86A:
2.1		 2hrcA-1k86A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 9 PHE A 106
LEU A 299
LEU A 262
LEU A 249
PHE A 182
 None
 1.27A 2vcvH-1k86A:
undetectable		 2vcvH-1k86A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 9 PHE A 106
LEU A 299
LEU A 262
LEU A 249
PHE A 182
 None
 1.22A 2vcvI-1k86A:
undetectable		 2vcvI-1k86A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1k86 CASPASE-7
(Homo
sapiens) 		4 / 8 TYR A 111
LEU A 122
LYS A 125
ALA A 126
 None
 0.77A 2wekA-1k86A:
3.9		 2wekA-1k86A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 10 PHE A 182
ALA A  96
PHE A 101
PHE A 106
LEU A 104
 None
 1.37A 3a3yA-1k86A:
2.6		 3a3yA-1k86A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1k86 CASPASE-7
(Homo
sapiens) 		4 / 7 LEU A 191
TYR A 230
VAL A 265
ILE A 288
 None
 1.06A 3ik3A-1k86A:
undetectable		 3ik3A-1k86A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1k86 CASPASE-7
(Homo
sapiens) 		4 / 7 LEU A 191
TYR A 230
VAL A 265
ILE A 288
 None
 1.06A 3ik3B-1k86A:
undetectable		 3ik3B-1k86A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 9 LEU A 295
ARG A 264
TYR A 300
LEU A 104
VAL A 291
 None
 1.24A 3m7rA-1k86A:
0.0		 3m7rA-1k86A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1k86 CASPASE-7
(Homo
sapiens) 		4 / 7 ILE A 258
PHE A 101
PHE A 106
LEU A 104
 None
 0.79A 3v7pA-1k86A:
0.3		 3v7pA-1k86A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 12 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
 None
 1.15A 4j24C-1k86A:
undetectable		 4j24C-1k86A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 12 MET A 119
LEU A 123
ILE A 183
ILE A 150
LEU A 142
 None
 1.14A 4j26B-1k86A:
undetectable		 4j26B-1k86A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1k86 CASPASE-7
(Homo
sapiens) 		4 / 7 VAL A 108
ILE A 109
LEU A 162
LEU A 123
 None
 0.89A 4xo7A-1k86A:
undetectable		 4xo7A-1k86A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 6 SER A 275
GLU A 274
GLY A  89
ASP A  93
GLY A 236
 None
 1.44A 5cdnA-1k86A:
0.0
5cdnB-1k86A:
undetectable		 5cdnA-1k86A:
19.04
5cdnB-1k86A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1k86 CASPASE-7
(Homo
sapiens) 		5 / 12 MET A 119
LEU A 123
ILE A 150
LEU A 162
LEU A 142
 None
 1.28A 5toaB-1k86A:
undetectable		 5toaB-1k86A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1k86 CASPASE-7
(Homo
sapiens) 		4 / 7 ASN A  75
ILE A 183
LEU A 141
MET A 119
 None
 1.03A 5u4sA-1k86A:
5.7		 5u4sA-1k86A:
22.85