SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		4 / 4 THR A 178
LEU A 179
VAL A  28
LEU A   5
 None
 1.02A 1fbmB-1k8dA:
undetectable		 1fbmB-1k8dA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		3 / 3 ALA A 187
VAL A 189
TRP A 217
 None
 0.83A 1w5uC-1k8dA:
undetectable
1w5uD-1k8dA:
undetectable		 1w5uC-1k8dA:
4.40
1w5uD-1k8dA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.89A 2zm8A-1k8dA:
0.0		 2zm8A-1k8dA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.95A 2zmaA-1k8dA:
0.0		 2zmaA-1k8dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		3 / 3 ALA A 187
VAL A 189
TRP A 217
 None
 0.78A 3l8lC-1k8dA:
undetectable
3l8lD-1k8dA:
undetectable		 3l8lC-1k8dA:
4.40
3l8lD-1k8dA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		5 / 10 PHE A 116
ILE A 124
ASP A 156
ILE A 152
LEU A 114
 None
 0.72A 3o1cA-1k8dA:
undetectable		 3o1cA-1k8dA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		5 / 10 PHE A 116
ILE A 124
ASP A 156
ILE A 152
LEU A 114
 None
 0.71A 3o1xA-1k8dA:
undetectable		 3o1xA-1k8dA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		5 / 10 PHE A 116
ILE A 124
ASP A 156
ILE A 152
LEU A 114
 None
 0.77A 3qgzA-1k8dA:
undetectable		 3qgzA-1k8dA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 1k8d QA-2 ANTIGEN
(Mus
musculus) 		5 / 12 PHE A 116
ILE A 124
ASP A 156
ILE A 152
LEU A 114
 None
 0.83A 5uvmB-1k8dA:
undetectable		 5uvmB-1k8dA:
16.25