SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 383
ILE A 363
LEU A 361
GLU A 343
 None
 0.92A 2ya7A-1k8fA:
undetectable		 2ya7A-1k8fA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 383
ILE A 363
LEU A 361
GLU A 343
 None
 0.87A 2ya7B-1k8fA:
0.0		 2ya7B-1k8fA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 383
ILE A 363
LEU A 361
GLU A 343
 None
 0.90A 2ya7D-1k8fA:
0.0		 2ya7D-1k8fA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 440
PHE A 382
GLY A 379
THR A 413
ILE A 410
 None
 1.38A 3jusB-1k8fA:
0.0		 3jusB-1k8fA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		4 / 4 ILE A 367
ASN A 368
ILE A 388
VAL A 389
 None
 1.29A 4uy87-1k8fA:
undetectable		 4uy87-1k8fA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		5 / 12 ASN A 333
VAL A 321
TYR A 354
ILE A 370
SER A 369
 None
 1.43A 4xueA-1k8fA:
undetectable		 4xueA-1k8fA:
22.58