SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		4 / 6 SER A 294
LEU A 290
SER A 275
ASP A 223
 None
 1.23A 2j2pE-1k8gA:
0.0
2j2pF-1k8gA:
0.0		 2j2pE-1k8gA:
20.06
2j2pF-1k8gA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 LEU A  41
CYH A  74
ALA A 138
ALA A  56
VAL A  58
 None
 1.03A 3b0wA-1k8gA:
0.0		 3b0wA-1k8gA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 LEU A  41
CYH A  74
ALA A 138
ALA A  56
VAL A  58
 None
 1.03A 3b0wB-1k8gA:
0.0		 3b0wB-1k8gA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		4 / 5 VAL A 226
VAL A 227
THR A 255
THR A 212
 None
 1.28A 3bjwD-1k8gA:
0.0		 3bjwD-1k8gA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 SER A 291
ILE A 273
ASP A 225
ALA A 276
ILE A 289
 None
 1.00A 3ddyA-1k8gA:
0.0		 3ddyA-1k8gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 THR A  62
ILE A 273
ASP A 225
ALA A 276
ILE A 289
 None
 1.15A 3ddyA-1k8gA:
0.0		 3ddyA-1k8gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 LEU A 129
LEU A  46
ALA A  44
LEU A  83
ASP A  80
 None
 1.08A 3gwuA-1k8gA:
undetectable		 3gwuA-1k8gA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 ILE A  59
ALA A  61
LEU A 100
GLN A 135
LEU A  41
 None
 1.17A 3ix9A-1k8gA:
undetectable		 3ix9A-1k8gA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 ILE A  78
ASP A 223
ASP A 225
ARG A 272
ASP A  60
 None
 1.33A 3phaB-1k8gA:
undetectable		 3phaB-1k8gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 ILE A  78
ASP A 223
ASP A 225
ARG A 272
ASP A  60
 None
 1.40A 3phaC-1k8gA:
undetectable		 3phaC-1k8gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 ILE A  78
ASP A 223
ASP A 225
ARG A 272
ASP A  60
 None
 1.45A 3phaD-1k8gA:
undetectable		 3phaD-1k8gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		4 / 5 TYR A 293
THR A  62
PHE A  63
LEU A 290
 None
 1.26A 3qelC-1k8gA:
undetectable		 3qelC-1k8gA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		4 / 8 TYR A  55
ALA A 179
SER A 176
SER A 145
 None
SO4  A 322 ( 4.3A)
SO4  A 322 ( 3.9A)
SO4  A 322 (-2.9A)
 1.00A 3rodA-1k8gA:
undetectable		 3rodA-1k8gA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 LEU A 189
TYR A  55
ILE A 181
ALA A 179
LEU A 100
 None
None
None
SO4  A 322 ( 4.3A)
None
 1.12A 3vw1B-1k8gA:
undetectable		 3vw1B-1k8gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 12 PHE A 136
ILE A 120
ASP A 118
LEU A  83
ALA A  98
 None
 1.17A 5h5fA-1k8gA:
undetectable		 5h5fA-1k8gA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		3 / 3 VAL A 140
SER A 145
TRP A 146
 None
SO4  A 322 (-2.9A)
None
 0.85A 5jwaA-1k8gA:
undetectable		 5jwaA-1k8gA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		4 / 7 SER A 249
ASP A 247
PHE A 253
ASN A 215
 None
 1.24A 5l1fC-1k8gA:
undetectable		 5l1fC-1k8gA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		5 / 11 LEU A 290
SER A 257
VAL A 287
THR A 277
ALA A 276
 None
 1.11A 5o96A-1k8gA:
undetectable
5o96B-1k8gA:
undetectable		 5o96A-1k8gA:
21.86
5o96B-1k8gA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT
(Sterkiella
nova) 		4 / 6 VAL A 122
PRO A 111
ALA A 125
THR A 126
 None
 1.05A 6cduB-1k8gA:
0.0
6cduC-1k8gA:
0.0		 6cduB-1k8gA:
22.35
6cduC-1k8gA:
22.35