SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1k8i MHC CLASS II H2-M
BETA 2 CHAIN
(Mus
musculus) 		4 / 7 GLU B  55
LYS B  41
ASN B  62
PRO B  44
 None
 1.39A 2ejgB-1k8iB:
undetectable		 2ejgB-1k8iB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1k8i MHC CLASS II H2-M
ALPHA CHAIN
MHC CLASS II H2-M
BETA 2 CHAIN
(Mus
musculus) 		4 / 5 GLN A 156
THR A 154
GLU B   7
THR B   9
 None
 1.37A 3glqA-1k8iA:
undetectable		 3glqA-1k8iA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1k8i MHC CLASS II H2-M
ALPHA CHAIN
MHC CLASS II H2-M
BETA 2 CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 ALA A  68
ILE A  69
HIS A  17
HIS B  81
 None
 1.15A 3nneG-1k8iA:
undetectable		 3nneG-1k8iA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1k8i MHC CLASS II H2-M
BETA 2 CHAIN
(Mus
musculus) 		4 / 8 ILE B 184
SER B 178
THR B 154
VAL B 126
 None
 0.81A 3ua5A-1k8iB:
undetectable		 3ua5A-1k8iB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1k8i MHC CLASS II H2-M
BETA 2 CHAIN
(Mus
musculus) 		4 / 7 VAL B 174
GLN B 176
MET B 131
LEU B 136
 None
 1.11A 4hxyB-1k8iB:
undetectable		 4hxyB-1k8iB:
17.95