SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 8 LEU A   5
HIS A   6
ASP A 257
LEU A 256
 None
 0.78A 1e7cA-1k8qA:
0.0		 1e7cA-1k8qA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		5 / 12 PHE A 121
TRP A 119
ARG A 106
ALA A  71
ALA A 265
 None
 1.25A 2bxpA-1k8qA:
undetectable		 2bxpA-1k8qA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		3 / 3 VAL A 150
VAL A 318
ASP A 361
 None
 0.77A 2fumD-1k8qA:
undetectable		 2fumD-1k8qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 7 HIS A 274
TYR A 306
PRO A 304
TYR A 307
 None
 1.26A 2ombC-1k8qA:
undetectable
2ombD-1k8qA:
undetectable		 2ombC-1k8qA:
19.09
2ombD-1k8qA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 5 LEU A 131
GLY A  97
ILE A 138
ILE A 135
 None
 0.80A 2q9rA-1k8qA:
0.1		 2q9rA-1k8qA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		5 / 12 PHE A  62
TYR A 149
THR A  34
ALA A 133
ILE A 158
 None
 1.23A 2qm9B-1k8qA:
undetectable		 2qm9B-1k8qA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		5 / 12 VAL A 366
ILE A 370
PHE A 176
PHE A 160
ALA A 327
 None
 1.14A 3apwA-1k8qA:
0.0		 3apwA-1k8qA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		5 / 12 VAL A 366
ILE A 370
PHE A 176
PHE A 160
ALA A 327
 None
 1.13A 3apwB-1k8qA:
0.0		 3apwB-1k8qA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		5 / 12 VAL A 366
PHE A 176
PHE A 160
LEU A 335
ALA A 327
 None
 0.94A 3apxA-1k8qA:
0.0		 3apxA-1k8qA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 8 ASN A 352
LEU A 326
ALA A 180
SER A 153
 None
C11  A2001 (-4.4A)
None
C11  A2001 (-1.5A)
 0.98A 3kp6A-1k8qA:
undetectable		 3kp6A-1k8qA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		3 / 3 SER A 281
ASP A 331
ASP A 324
 None
 0.75A 3uj7A-1k8qA:
2.9		 3uj7A-1k8qA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		3 / 3 ASP A 331
GLY A 282
TYR A 187
 None
 0.78A 3w9tC-1k8qA:
undetectable		 3w9tC-1k8qA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		3 / 3 ASP A 331
GLY A 282
TYR A 187
 None
 0.78A 3w9tG-1k8qA:
undetectable		 3w9tG-1k8qA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 8 SER A  99
ILE A 173
VAL A 314
PHE A 176
 None
 0.97A 4dx7B-1k8qA:
undetectable		 4dx7B-1k8qA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		3 / 3 HIS A  65
TRP A 358
SER A  99
 None
 1.06A 4lrhD-1k8qA:
undetectable		 4lrhD-1k8qA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 8 VAL A  94
LEU A  63
ILE A 357
VAL A 366
 None
 0.95A 4ma7A-1k8qA:
undetectable		 4ma7A-1k8qA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		3 / 3 SER A 281
ASP A 331
ASP A 324
 None
 0.76A 4mwzA-1k8qA:
undetectable		 4mwzA-1k8qA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 7 GLY A 321
LEU A 309
PHE A 284
ASP A 333
 None
 0.86A 5hieB-1k8qA:
undetectable		 5hieB-1k8qA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 6 VAL A 318
HIS A 345
LEU A 342
LEU A 335
 None
 1.18A 5hrqB-1k8qA:
undetectable
5hrqI-1k8qA:
undetectable
5hrqJ-1k8qA:
undetectable		 5hrqB-1k8qA:
6.13
5hrqI-1k8qA:
5.60
5hrqJ-1k8qA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 8 TRP A 275
GLN A 154
ALA A 278
GLN A 285
 C11  A2001 ( 3.7A)
None
None
None
 1.14A 5km8A-1k8qA:
undetectable
5km8B-1k8qA:
undetectable		 5km8A-1k8qA:
18.40
5km8B-1k8qA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 7 GLN A  64
TYR A 149
ASP A 130
TYR A  38
 None
 1.29A 5vlmG-1k8qA:
undetectable		 5vlmG-1k8qA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		5 / 12 GLY A 155
VAL A 318
ILE A  75
GLY A  97
ALA A  84
 None
 1.00A 6c2mD-1k8qA:
0.0		 6c2mD-1k8qA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 9 VAL A 185
LEU A  68
VAL A 269
SER A 268
 C11  A2001 ( 4.9A)
C11  A2001 ( 4.8A)
None
None
 0.99A 6c2mD-1k8qA:
undetectable		 6c2mD-1k8qA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		5 / 12 SER A  99
PHE A  62
LEU A 139
ASP A 130
PHE A 163
 None
 1.15A 6dwnA-1k8qA:
0.0		 6dwnA-1k8qA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		5 / 12 ASN A  73
LEU A 179
GLY A 155
GLY A 151
SER A  99
 BOG  A1006 ( 4.5A)
None
None
None
None
 1.06A 6ectA-1k8qA:
undetectable		 6ectA-1k8qA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 6 TRP A 319
GLY A  66
ALA A 180
LEU A 179
 None
C11  A2001 (-3.4A)
None
None
 1.01A 6fosA-1k8qA:
undetectable		 6fosA-1k8qA:
13.56