SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1k94 GRANCALCIN
(Homo
sapiens) 		3 / 3 THR A 159
PRO A 157
THR A 161
 None
 0.80A 209dC-1k94A:
undetectable		 209dC-1k94A:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1k94 GRANCALCIN
(Homo
sapiens) 		5 / 12 ASN A  83
PHE A  89
THR A  85
VAL A 179
LEU A 121
 None
 1.30A 3elzA-1k94A:
undetectable		 3elzA-1k94A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1k94 GRANCALCIN
(Homo
sapiens) 		3 / 3 ASP A 134
SER A 136
ARG A 172
 CA  A 998 (-2.8A)
CA  A 998 (-2.4A)
None
 0.79A 3loqA-1k94A:
undetectable		 3loqA-1k94A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1k94 GRANCALCIN
(Homo
sapiens) 		4 / 7 ASP A 190
GLY A 213
THR A 214
ILE A 217
 None
 0.78A 4acaC-1k94A:
undetectable		 4acaC-1k94A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1k94 GRANCALCIN
(Homo
sapiens) 		5 / 11 SER A 136
VAL A 131
THR A 138
ALA A 147
HIS A 142
 CA  A 998 (-2.4A)
None
None
None
None
 1.25A 4e0fA-1k94A:
undetectable		 4e0fA-1k94A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1k94 GRANCALCIN
(Homo
sapiens) 		5 / 9 PHE A 191
GLY A 213
ILE A  98
LEU A 101
ASP A 104
 None
 1.44A 6c2mC-1k94A:
undetectable		 6c2mC-1k94A:
17.18