SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1k9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 THR A 422
THR A 424
PRO A 421
 None
 0.81A 1dscC-1k9xA:
undetectable		 1dscC-1k9xA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 ALA A 413
ALA A 118
LYS A 117
GLU A 120
 None
 1.09A 1e7cA-1k9xA:
2.9		 1e7cA-1k9xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 171
ASP A 161
ASP A 484
 None
 0.77A 1eizA-1k9xA:
undetectable		 1eizA-1k9xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 171
ASP A 161
ASP A 484
 None
 0.72A 1ej0A-1k9xA:
undetectable		 1ej0A-1k9xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 GLU A 256
HIS A 269
GLU A 270
HIS A 273
GLU A 299
 None
 1.08A 1o86A-1k9xA:
20.7		 1o86A-1k9xA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 4 SER A 140
VAL A 374
PHE A 104
VAL A 108
 None
 1.49A 1o86A-1k9xA:
20.7		 1o86A-1k9xA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 499
LEU A 191
VAL A 345
VAL A 494
 None
 0.96A 2bdmA-1k9xA:
0.0		 2bdmA-1k9xA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		6 / 12 THR A 424
TYR A 423
ILE A 308
LEU A 265
GLY A 310
HIS A 269
 None
 1.44A 2fk8A-1k9xA:
undetectable		 2fk8A-1k9xA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 315
LEU A 323
GLU A 306
ARG A 311
 None
 0.99A 2jn3A-1k9xA:
undetectable		 2jn3A-1k9xA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 PHE A 342
TYR A 255
VAL A 268
LEU A 265
 None
 0.73A 2w98B-1k9xA:
undetectable		 2w98B-1k9xA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 255
PRO A 239
ASN A 216
LEU A 220
 None
 1.22A 2wekA-1k9xA:
0.0		 2wekA-1k9xA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 219
GLY A 272
PHE A 304
VAL A 448
LEU A 265
 None
 1.27A 3elzB-1k9xA:
undetectable		 3elzB-1k9xA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 SER A 302
GLN A 301
PHE A 304
 None
 0.81A 3g4lC-1k9xA:
1.0		 3g4lC-1k9xA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		5 / 9 PHE A 420
GLY A 418
PRO A 421
GLY A 415
PHE A 176
 None
 1.49A 3ko0H-1k9xA:
undetectable
3ko0I-1k9xA:
0.0		 3ko0H-1k9xA:
13.54
3ko0I-1k9xA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 VAL A 338
VAL A 215
TYR A 320
ILE A 319
 None
 1.00A 3remA-1k9xA:
undetectable		 3remA-1k9xA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 VAL A 338
VAL A 215
TYR A 320
ILE A 319
 None
 1.02A 3remB-1k9xA:
undetectable		 3remB-1k9xA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 ARG A 366
PHE A 420
PRO A 421
 None
 0.73A 3zoaB-1k9xA:
undetectable		 3zoaB-1k9xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 ARG A 303
ASP A 409
GLN A 408
 None
 0.83A 4azsA-1k9xA:
undetectable		 4azsA-1k9xA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 359
HIS A 269
ARG A 303
 None
 1.10A 4htfA-1k9xA:
undetectable		 4htfA-1k9xA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 269
GLU A 270
HIS A 273
GLU A 299
LEU A 167
 None
 1.31A 4r7lA-1k9xA:
6.4		 4r7lA-1k9xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 309
GLY A 310
ARG A 303
HIS A 269
VAL A 268
 None
 0.94A 4rvdA-1k9xA:
undetectable		 4rvdA-1k9xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 348
ARG A 303
ARG A 311
 None
 0.89A 4x5iA-1k9xA:
0.0		 4x5iA-1k9xA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 188
LEU A 395
GLY A 396
 None
 0.53A 4xmfA-1k9xA:
0.0		 4xmfA-1k9xA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 348
ARG A 303
ARG A 311
 None
 0.95A 5eajB-1k9xA:
0.0		 5eajB-1k9xA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 GLU A 317
GLU A 314
VAL A 338
GLU A 336
TYR A 339
 None
 1.34A 5iqdB-1k9xA:
1.3		 5iqdB-1k9xA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 GLU A 317
GLU A 314
VAL A 338
GLU A 336
TYR A 339
 None
 1.37A 5iqdD-1k9xA:
0.0		 5iqdD-1k9xA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 292
SER A 430
LEU A 433
ARG A 461
GLN A 279
 None
 1.13A 5o96A-1k9xA:
undetectable
5o96B-1k9xA:
undetectable		 5o96A-1k9xA:
19.57
5o96B-1k9xA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 276
HIS A 298
LEU A 278
VAL A 249
 None
 1.22A 6g2pA-1k9xA:
undetectable		 6g2pA-1k9xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1k9x M32 CARBOXYPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 ASP A 348
GLU A 203
ASP A 259
GLU A 256
 None
 1.20A 6mn5B-1k9xA:
0.0		 6mn5B-1k9xA:
10.45