SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ka0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 261
HIS A 244
LEU A 280
THR A 233
 None
 1.03A 1am6A-1ka0A:
0.0		 1am6A-1ka0A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 261
HIS A 244
LEU A 282
LEU A 280
THR A 233
 None
 1.17A 1dmyA-1ka0A:
undetectable		 1dmyA-1ka0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 306
HIS A 303
ALA A 206
HIS A 309
ALA A 200
 None
 1.15A 1gtnM-1ka0A:
0.0
1gtnN-1ka0A:
0.0		 1gtnM-1ka0A:
12.32
1gtnN-1ka0A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 306
HIS A 303
ALA A 206
HIS A 309
ALA A 200
 None
 1.11A 1gtnO-1ka0A:
0.0
1gtnP-1ka0A:
0.0		 1gtnO-1ka0A:
12.32
1gtnP-1ka0A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 8 THR A 147
GLY A 146
GLY A 153
PHE A 150
LEU A 151
 NA  A 501 ( 4.9A)
AMP  A 401 ( 4.1A)
None
None
None
 1.42A 1jhvA-1ka0A:
undetectable		 1jhvA-1ka0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 277
VAL A 278
SER A 334
ASP A 227
 None
 1.47A 1n2xB-1ka0A:
undetectable		 1n2xB-1ka0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 170
ALA A  59
ALA A  10
VAL A 201
LEU A 204
 None
 1.17A 1rlbF-1ka0A:
0.3		 1rlbF-1ka0A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 174
SER A 211
ALA A 266
ALA A 157
ASP A 145
 None
 1.13A 2avdA-1ka0A:
2.1		 2avdA-1ka0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  20
PHE A 150
VAL A 158
ALA A  52
 None
 1.12A 2cizA-1ka0A:
0.0		 2cizA-1ka0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 151
GLN A  25
GLU A  27
ILE A  24
 None
 1.11A 2fcnA-1ka0A:
0.0
2fcnB-1ka0A:
0.0		 2fcnA-1ka0A:
14.75
2fcnB-1ka0A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  70
GLU A  72
ARG A 324
PRO A 143
 None
NA  A 501 (-3.2A)
None
NA  A 501 ( 4.8A)
 1.01A 2v32C-1ka0A:
undetectable
2v32D-1ka0A:
undetectable		 2v32C-1ka0A:
18.89
2v32D-1ka0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  60
ILE A  56
ALA A 200
VAL A 201
PHE A 198
 None
 1.15A 2yvlB-1ka0A:
undetectable		 2yvlB-1ka0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  60
ILE A  56
ALA A 200
VAL A 201
PHE A 198
 None
 1.18A 2yvlC-1ka0A:
undetectable		 2yvlC-1ka0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 232
ILE A 256
LYS A 251
GLU A 235
LEU A 234
 None
 1.29A 3f78B-1ka0A:
undetectable		 3f78B-1ka0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 170
LEU A   3
ARG A   5
 None
 0.75A 3hcnB-1ka0A:
undetectable		 3hcnB-1ka0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 245
GLY A 240
SER A 242
ILE A 284
 None
 0.83A 3ihzB-1ka0A:
undetectable		 3ihzB-1ka0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 340
ILE A 332
ALA A 333
ALA A 276
THR A 233
 None
 1.19A 3mdtA-1ka0A:
undetectable		 3mdtA-1ka0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 9 ILE A  37
LEU A 151
THR A  21
LEU A 141
GLY A 146
 None
None
None
None
AMP  A 401 ( 4.1A)
 1.49A 3nxuB-1ka0A:
0.0		 3nxuB-1ka0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 319
GLY A 321
PRO A 317
ARG A 202
 None
 0.97A 3s3mA-1ka0A:
undetectable		 3s3mA-1ka0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 143
GLN A  53
GLY A 128
VAL A  69
 NA  A 501 ( 4.8A)
None
None
None
 0.99A 4a3uB-1ka0A:
undetectable		 4a3uB-1ka0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 5 ALA A  52
THR A  21
VAL A  28
ILE A  24
 None
 0.90A 4xe3B-1ka0A:
undetectable		 4xe3B-1ka0A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 343
ASP A 315
ILE A 256
 None
 0.64A 4xi3D-1ka0A:
2.8		 4xi3D-1ka0A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 306
HIS A 303
ALA A 206
HIS A 309
ALA A 200
 None
 1.20A 5eeuQ-1ka0A:
0.0
5eeuR-1ka0A:
0.0		 5eeuQ-1ka0A:
12.32
5eeuR-1ka0A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 306
HIS A 303
ALA A 206
HIS A 309
ALA A 200
 None
 1.20A 5eevQ-1ka0A:
0.0
5eevR-1ka0A:
0.0		 5eevQ-1ka0A:
12.32
5eevR-1ka0A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 306
HIS A 303
ALA A 206
HIS A 309
ALA A 200
 None
 1.19A 5eewQ-1ka0A:
0.0
5eewR-1ka0A:
0.0		 5eewQ-1ka0A:
12.32
5eewR-1ka0A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 281
ASP A 145
GLY A 146
ASP A 142
 AMP  A 401 (-3.1A)
None
AMP  A 401 ( 4.1A)
NA  A 501 (-2.8A)
 1.35A 5hp1C-1ka0A:
0.0		 5hp1C-1ka0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 220
GLY A 307
GLY A 274
LEU A 275
GLY A 205
 None
 1.22A 5i71A-1ka0A:
0.0		 5i71A-1ka0A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 6 SER A  75
GLY A 128
ASN A 129
ILE A 124
 None
 0.94A 5j4nA-1ka0A:
0.0		 5j4nA-1ka0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 342
LEU A 326
ALA A 333
SER A 334
ARG A 338
 None
 1.19A 5syfB-1ka0A:
undetectable		 5syfB-1ka0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 7 THR A 109
LEU A 115
ILE A  55
THR A  54
 None
 0.98A 5zsfA-1ka0A:
0.0
5zsfB-1ka0A:
0.0		 5zsfA-1ka0A:
10.76
5zsfB-1ka0A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 183
SER A 264
ALA A 157
LEU A 273
ALA A 276
 None
 1.38A 6efnA-1ka0A:
undetectable		 6efnA-1ka0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1ka0 HALOTOLERANCE
PROTEIN HAL2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  57
GLN A  53
GLU A  72
VAL A  69
 None
None
NA  A 501 (-3.2A)
None
 1.03A 6j20A-1ka0A:
0.1		 6j20A-1ka0A:
21.01