SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ka8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRK_B_TFPB203_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	1ka8	PUTATIVE P4-SPECIFIC DNA PRIMASE (Enterobacteria phage P4)	4 / 5	PHE A 8 LEU A 89 PHE A 59 MET A 23	None	1.33A	1wrkB-1ka8A: undetectable	1wrkB-1ka8A: 17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XFH_A_CL6A1414_1 (ERYTHROMYCIN B/D C-12 HYDROXYLASE)	1ka8	PUTATIVE P4-SPECIFIC DNA PRIMASE (Enterobacteria phage P4)	5 / 8	LEU A 67 ILE A 9 LEU A 63 THR A 85 LEU A 87	None	1.46A	2xfhA-1ka8A: undetectable	2xfhA-1ka8A: 12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_H_ACTH502_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	1ka8	PUTATIVE P4-SPECIFIC DNA PRIMASE (Enterobacteria phage P4)	3 / 3	SER A 19 GLY A 20 GLN A 84	None	0.64A	3v4tH-1ka8A: 0.0	3v4tH-1ka8A: 12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OJB_A_198A1001_1 (ANDROGEN RECEPTOR)	1ka8	PUTATIVE P4-SPECIFIC DNA PRIMASE (Enterobacteria phage P4)	5 / 12	LEU A 63 GLY A 60 LEU A 56 MET A 23 MET A 21	None	1.26A	4ojbA-1ka8A: undetectable	4ojbA-1ka8A: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKB_A_198A1002_1 (ANDROGEN RECEPTOR)	1ka8	PUTATIVE P4-SPECIFIC DNA PRIMASE (Enterobacteria phage P4)	5 / 12	LEU A 63 GLY A 60 LEU A 56 MET A 23 MET A 21	None	1.20A	4okbA-1ka8A: 0.0	4okbA-1ka8A: 21.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WRK_B_TFPB203_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","1ka8","PUTATIVE P4-SPECIFIC DNA PRIMASE","Enterobacteria phage P4",4,"PHE A   8;LEU A  89;PHE A  59;MET A  23","None","1.33A","1wrkB-1ka8A:undetectable","1wrkB-1ka8A:17.82"],["2XFH_A_CL6A1414_1","ERYTHROMYCIN B\/D C-12 HYDROXYLASE","1ka8","PUTATIVE P4-SPECIFIC DNA PRIMASE","Enterobacteria phage P4",5,"LEU A  67;ILE A   9;LEU A  63;THR A  85;LEU A  87","None","1.46A","2xfhA-1ka8A:undetectable","2xfhA-1ka8A:12.56"],["3V4T_H_ACTH502_0","UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE","1ka8","PUTATIVE P4-SPECIFIC DNA PRIMASE","Enterobacteria phage P4",3,"SER A  19;GLY A  20;GLN A  84","None","0.64A","3v4tH-1ka8A:0.0","3v4tH-1ka8A:12.74"],["4OJB_A_198A1001_1","ANDROGEN RECEPTOR","1ka8","PUTATIVE P4-SPECIFIC DNA PRIMASE","Enterobacteria phage P4",5,"LEU A  63;GLY A  60;LEU A  56;MET A  23;MET A  21","None","1.26A","4ojbA-1ka8A:undetectable","4ojbA-1ka8A:21.92"],["4OKB_A_198A1002_1","ANDROGEN RECEPTOR","1ka8","PUTATIVE P4-SPECIFIC DNA PRIMASE","Enterobacteria phage P4",5,"LEU A  63;GLY A  60;LEU A  56;MET A  23;MET A  21","None","1.20A","4okbA-1ka8A:0.0","4okbA-1ka8A:21.92"]]