SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 VAL A  43
VAL A 200
ILE A 190
GLY A 185
ALA A 189
LEU A  51
 None
None
None
NAD  A1201 ( 4.2A)
None
None
 1.50A 1eqhB-1kaeA:
undetectable		 1eqhB-1kaeA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		6 / 9 LEU A 138
SER A 140
HIS A 262
ASP A 360
TYR A 361
HIS A 367
 HSO  A1001 ( 4.1A)
HSO  A1001 (-3.5A)
ZN  A1101 ( 3.3A)
HSO  A1001 ( 2.7A)
HSO  A1001 (-4.4A)
HSO  A1001 (-3.5A)
 0.23A 1karA-1kaeA:
57.4
1karB-1kaeA:
56.1		 1karA-1kaeA:
100.00
1karB-1kaeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		6 / 9 LEU A 138
SER A 140
HIS A 262
ASP A 360
TYR A 361
HIS A 367
 HSO  A1001 ( 4.1A)
HSO  A1001 (-3.5A)
ZN  A1101 ( 3.3A)
HSO  A1001 ( 2.7A)
HSO  A1001 (-4.4A)
HSO  A1001 (-3.5A)
 0.21A 1karA-1kaeA:
57.4
1karB-1kaeA:
56.1		 1karA-1kaeA:
100.00
1karB-1kaeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.87A 1muiA-1kaeA:
undetectable		 1muiA-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 1muiB-1kaeA:
undetectable		 1muiB-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.91A 1rl8A-1kaeA:
undetectable		 1rl8A-1kaeA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.80A 1sdvB-1kaeA:
undetectable		 1sdvB-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 SER A  69
VAL A 178
ALA A 173
ILE A 169
PHE A 182
 None
 1.19A 1uduA-1kaeA:
undetectable		 1uduA-1kaeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.87A 2avoB-1kaeA:
undetectable		 2avoB-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.87A 2avvD-1kaeA:
undetectable		 2avvD-1kaeA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.82A 2bpxB-1kaeA:
undetectable		 2bpxB-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.78A 2f81A-1kaeA:
undetectable		 2f81A-1kaeA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.82A 2f81B-1kaeA:
undetectable		 2f81B-1kaeA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.84A 2f8gA-1kaeA:
undetectable		 2f8gA-1kaeA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.91A 2f8gB-1kaeA:
undetectable		 2f8gB-1kaeA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 348
ILE A 330
LEU A 328
ILE A 242
ALA A 314
 None
 1.13A 2gj5A-1kaeA:
0.0		 2gj5A-1kaeA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.86A 2hs1A-1kaeA:
undetectable		 2hs1A-1kaeA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.93A 2hs2A-1kaeA:
undetectable		 2hs2A-1kaeA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.81A 2hs2B-1kaeA:
undetectable		 2hs2B-1kaeA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.77A 2ienA-1kaeA:
undetectable		 2ienA-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.85A 2ienB-1kaeA:
undetectable		 2ienB-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 LEU A 143
THR A 141
ILE A 151
HIS A  99
 None
NAD  A1201 ( 4.1A)
None
None
 1.31A 2jfaB-1kaeA:
0.0		 2jfaB-1kaeA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.83A 2o4sB-1kaeA:
undetectable		 2o4sB-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.83A 2r5pB-1kaeA:
undetectable		 2r5pB-1kaeA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.83A 2r5pD-1kaeA:
undetectable		 2r5pD-1kaeA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.87A 2rkfB-1kaeA:
undetectable		 2rkfB-1kaeA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.84A 2rkgA-1kaeA:
undetectable		 2rkgA-1kaeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.83A 2rkgB-1kaeA:
undetectable		 2rkgB-1kaeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 407
THR A 406
LEU A 395
VAL A 423
GLU A 398
 None
 1.20A 2vn0A-1kaeA:
0.0		 2vn0A-1kaeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 9 ILE A 342
ALA A 314
VAL A 317
GLU A 318
 None
 0.65A 2vufA-1kaeA:
0.0		 2vufA-1kaeA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 PRO A 132
SER A 161
ILE A 169
GLY A 134
 NAD  A1201 (-3.6A)
None
None
None
 0.90A 2y7kA-1kaeA:
undetectable		 2y7kA-1kaeA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.90A 2z54A-1kaeA:
undetectable		 2z54A-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 2z54B-1kaeA:
undetectable		 2z54B-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 TYR A 171
ALA A 172
LEU A 175
ALA A  91
 None
 0.74A 3b6hB-1kaeA:
undetectable		 3b6hB-1kaeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 3bvbB-1kaeA:
undetectable		 3bvbB-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.84A 3cywB-1kaeA:
undetectable		 3cywB-1kaeA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 3cyxB-1kaeA:
undetectable		 3cyxB-1kaeA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.84A 3d1zB-1kaeA:
undetectable		 3d1zB-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.77A 3d20A-1kaeA:
undetectable		 3d20A-1kaeA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.85A 3d20B-1kaeA:
undetectable		 3d20B-1kaeA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.81A 3ekpD-1kaeA:
undetectable		 3ekpD-1kaeA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.79A 3ektC-1kaeA:
undetectable		 3ektC-1kaeA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.79A 3ektD-1kaeA:
undetectable		 3ektD-1kaeA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 3ekvA-1kaeA:
undetectable		 3ekvA-1kaeA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 3ekxA-1kaeA:
undetectable		 3ekxA-1kaeA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.84A 3em3A-1kaeA:
undetectable		 3em3A-1kaeA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ASN A  37
THR A  33
ALA A 217
ARG A 219
 None
 0.77A 3kp6A-1kaeA:
0.0		 3kp6A-1kaeA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 ASN A  37
LEU A  40
ASP A  41
LYS A  44
 None
 1.23A 3lslA-1kaeA:
undetectable
3lslD-1kaeA:
undetectable		 3lslA-1kaeA:
20.27
3lslD-1kaeA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.84A 3lzsA-1kaeA:
undetectable		 3lzsA-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.82A 3lzsB-1kaeA:
undetectable		 3lzsB-1kaeA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.81A 3lzuA-1kaeA:
undetectable		 3lzuA-1kaeA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.87A 3lzuB-1kaeA:
undetectable		 3lzuB-1kaeA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 3ndwA-1kaeA:
undetectable		 3ndwA-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.91A 3ndxA-1kaeA:
undetectable		 3ndxA-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.89A 3nu3B-1kaeA:
undetectable		 3nu3B-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.86A 3nu4B-1kaeA:
undetectable		 3nu4B-1kaeA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 3nujB-1kaeA:
undetectable		 3nujB-1kaeA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 3nuoB-1kaeA:
undetectable		 3nuoB-1kaeA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 VAL A 252
MET A 277
ILE A 308
VAL A 239
LEU A 256
 None
 1.21A 3ogpB-1kaeA:
undetectable		 3ogpB-1kaeA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.91A 3oxvA-1kaeA:
undetectable		 3oxvA-1kaeA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.90A 3oxvC-1kaeA:
undetectable		 3oxvC-1kaeA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 LEU A 381
GLN A 102
HIS A  99
GLY A 382
 None
 1.21A 3pp1A-1kaeA:
0.0		 3pp1A-1kaeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 3pwmB-1kaeA:
undetectable		 3pwmB-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.83A 3s54A-1kaeA:
undetectable		 3s54A-1kaeA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.84A 3tkwA-1kaeA:
undetectable		 3tkwA-1kaeA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.81A 3tkwB-1kaeA:
undetectable		 3tkwB-1kaeA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.82A 3ttpA-1kaeA:
undetectable		 3ttpA-1kaeA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.82A 3ttpB-1kaeA:
undetectable		 3ttpB-1kaeA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 PHE A 213
SER A  29
SER A  31
 NAD  A1201 (-3.4A)
None
None
 0.86A 3ufgB-1kaeA:
undetectable		 3ufgB-1kaeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A 313
ILE A 330
ALA A 278
ALA A 274
VAL A 309
 None
 1.08A 4hfpD-1kaeA:
undetectable		 4hfpD-1kaeA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.82A 4jecA-1kaeA:
undetectable		 4jecA-1kaeA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.61A 4ll3A-1kaeA:
undetectable		 4ll3A-1kaeA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.83A 4ll3B-1kaeA:
undetectable		 4ll3B-1kaeA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.81A 4ll3A-1kaeA:
undetectable		 4ll3A-1kaeA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.90A 4njvA-1kaeA:
undetectable		 4njvA-1kaeA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.87A 4njvD-1kaeA:
undetectable		 4njvD-1kaeA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 GLU A 326
THR A 141
HIS A 367
 HSO  A1001 ( 4.1A)
NAD  A1201 ( 4.1A)
HSO  A1001 (-3.5A)
 0.84A 4q15A-1kaeA:
3.0		 4q15A-1kaeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 GLU A 326
THR A 141
HIS A 367
 HSO  A1001 ( 4.1A)
NAD  A1201 ( 4.1A)
HSO  A1001 (-3.5A)
 0.82A 4q15B-1kaeA:
2.9		 4q15B-1kaeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 ASN A 321
LEU A 240
VAL A 339
LEU A 338
ILE A 330
 None
 1.24A 4r38C-1kaeA:
undetectable		 4r38C-1kaeA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.92A 4rvjB-1kaeA:
undetectable		 4rvjB-1kaeA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.91A 4rvjD-1kaeA:
undetectable		 4rvjD-1kaeA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.86A 5e5jB-1kaeA:
undetectable		 5e5jB-1kaeA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A 208
ALA A 217
ILE A  39
ILE A  32
ALA A 191
PHE A  58
 None
None
None
None
None
NAD  A1201 (-3.6A)
 1.39A 5hesA-1kaeA:
undetectable		 5hesA-1kaeA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 178
PRO A 148
ALA A 149
VAL A 157
LEU A 193
 None
 1.20A 5hv1A-1kaeA:
0.0		 5hv1A-1kaeA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 VAL A  92
GLN A 174
CYH A 176
 None
 0.78A 5icxA-1kaeA:
0.0
5icxE-1kaeA:
undetectable		 5icxA-1kaeA:
22.92
5icxE-1kaeA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 HIS A 262
SER A 347
HIS A 367
SER A 140
 ZN  A1101 ( 3.3A)
None
HSO  A1001 (-3.5A)
HSO  A1001 (-3.5A)
 1.00A 5m8rB-1kaeA:
undetectable		 5m8rB-1kaeA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 THR A 406
ILE A 407
GLY A 399
ALA A 402
PHE A 400
 None
 1.07A 5mxbA-1kaeA:
undetectable		 5mxbA-1kaeA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 TYR A 372
TYR A 374
GLN A 267
HIS A 327
 None
None
None
HSO  A1001 (-3.9A)
 1.34A 5ov9B-1kaeA:
undetectable		 5ov9B-1kaeA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.88A 5t2zB-1kaeA:
undetectable		 5t2zB-1kaeA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.89A 5t8hB-1kaeA:
undetectable		 5t8hB-1kaeA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 1kae HISTIDINOL
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 227
ALA A 228
ASP A 204
GLY A 196
ILE A 206
 None
 0.91A 6dgxA-1kaeA:
undetectable		 6dgxA-1kaeA:
11.26