SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V55_C_CHDC3271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE III CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	1kaf	TRANSCRIPTION REGULATORY PROTEIN MOTA (Escherichia virus T4)	4 / 7	LYS A 130 LEU A 128 LEU A 121 PHE A 152	None	1.10A	1v55C-1kafA: undetectable 1v55J-1kafA: 0.0	1v55C-1kafA: 14.29 1v55J-1kafA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYS_C_CHDC310_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	1kaf	TRANSCRIPTION REGULATORY PROTEIN MOTA (Escherichia virus T4)	4 / 7	LYS A 130 LEU A 128 LEU A 121 PHE A 152	None	1.00A	2dysC-1kafA: undetectable 2dysJ-1kafA: 0.0	2dysC-1kafA: 14.29 2dysJ-1kafA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIJ_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	1kaf	TRANSCRIPTION REGULATORY PROTEIN MOTA (Escherichia virus T4)	4 / 7	LYS A 130 LEU A 128 LEU A 121 PHE A 152	None	1.06A	2eijC-1kafA: undetectable 2eijJ-1kafA: 0.0	2eijC-1kafA: 14.29 2eijJ-1kafA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIM_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	1kaf	TRANSCRIPTION REGULATORY PROTEIN MOTA (Escherichia virus T4)	4 / 7	LYS A 130 LEU A 128 LEU A 121 PHE A 152	None	1.04A	2eimC-1kafA: undetectable 2eimJ-1kafA: 0.0	2eimC-1kafA: 14.29 2eimJ-1kafA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W97_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1kaf	TRANSCRIPTION REGULATORY PROTEIN MOTA (Escherichia virus T4)	4 / 6	LYS A 130 LEU A 128 LEU A 121 PHE A 152	None	1.11A	5w97C-1kafA: undetectable 5w97J-1kafA: 0.0	5w97C-1kafA: 14.29 5w97J-1kafA: 19.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1V55_C_CHDC3271_0","CYTOCHROME C OXIDASE POLYPEPTIDE III;CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","1kaf","TRANSCRIPTION REGULATORY PROTEIN MOTA","Escherichia virus T4",4,"LYS A 130;LEU A 128;LEU A 121;PHE A 152","None","1.10A","1v55C-1kafA:undetectable;1v55J-1kafA:0.0","1v55C-1kafA:14.29;1v55J-1kafA:19.35"],["2DYS_C_CHDC310_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","1kaf","TRANSCRIPTION REGULATORY PROTEIN MOTA","Escherichia virus T4",4,"LYS A 130;LEU A 128;LEU A 121;PHE A 152","None","1.00A","2dysC-1kafA:undetectable;2dysJ-1kafA:0.0","2dysC-1kafA:14.29;2dysJ-1kafA:19.35"],["2EIJ_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","1kaf","TRANSCRIPTION REGULATORY PROTEIN MOTA","Escherichia virus T4",4,"LYS A 130;LEU A 128;LEU A 121;PHE A 152","None","1.06A","2eijC-1kafA:undetectable;2eijJ-1kafA:0.0","2eijC-1kafA:14.29;2eijJ-1kafA:19.35"],["2EIM_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","1kaf","TRANSCRIPTION REGULATORY PROTEIN MOTA","Escherichia virus T4",4,"LYS A 130;LEU A 128;LEU A 121;PHE A 152","None","1.04A","2eimC-1kafA:undetectable;2eimJ-1kafA:0.0","2eimC-1kafA:14.29;2eimJ-1kafA:19.35"],["5W97_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1kaf","TRANSCRIPTION REGULATORY PROTEIN MOTA","Escherichia virus T4",4,"LYS A 130;LEU A 128;LEU A 121;PHE A 152","None","1.11A","5w97C-1kafA:undetectable;5w97J-1kafA:0.0","5w97C-1kafA:14.29;5w97J-1kafA:19.35"]]