SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kaq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 ARG A 160
GLY A  17
ILE A 104
GLY A 106
THR A  10
 None
DND  A 601 ( 4.3A)
None
DND  A 601 (-3.2A)
DND  A 601 (-3.1A)
 0.95A 1c6zA-1kaqA:
undetectable		 1c6zA-1kaqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 8 PHE A  70
ILE A  34
PHE A   7
PHE A  11
HIS A  18
 None
None
DND  A 601 (-4.2A)
None
DND  A 601 (-4.0A)
 1.25A 1fslA-1kaqA:
undetectable		 1fslA-1kaqA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 10 GLY A  30
ALA A  29
ILE A 104
GLY A   5
ILE A   4
 None
 1.03A 1t7iA-1kaqA:
undetectable		 1t7iA-1kaqA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 PHE A  70
PHE A  36
PHE A  11
HIS A  18
 None
None
None
DND  A 601 (-4.0A)
 1.11A 2lh6A-1kaqA:
0.0		 2lh6A-1kaqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLY A   8
ILE A   4
LEU A  31
LEU A  26
VAL A  25
 DND  A 601 (-3.9A)
None
None
None
None
 0.88A 3adxB-1kaqA:
0.0		 3adxB-1kaqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 VAL A  75
GLN A  40
PHE A   7
ARG A  95
 None
None
DND  A 601 (-4.2A)
None
 1.33A 3bjwE-1kaqA:
0.0		 3bjwE-1kaqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 VAL A  75
GLN A  40
PHE A  36
ARG A  95
 None
 1.32A 3bjwE-1kaqA:
0.0		 3bjwE-1kaqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 HIS A  18
GLY A 106
PRO A  43
HIS A  44
GLY A   9
 DND  A 601 (-4.0A)
DND  A 601 (-3.2A)
DND  A 601 (-4.5A)
DND  A 601 (-3.3A)
DND  A 601 (-2.8A)
 1.09A 4bz6C-1kaqA:
undetectable		 4bz6C-1kaqA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 8 LEU A 101
LEU A  92
LEU A  91
LYS A   2
ILE A   4
 None
 1.29A 4klaA-1kaqA:
undetectable		 4klaA-1kaqA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 LEU A 145
ALA A  29
ILE A 104
ILE A  34
ILE A 129
 None
 1.03A 4q1yB-1kaqA:
undetectable		 4q1yB-1kaqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 8 LEU A 186
TYR A 180
GLU A  58
THR A  51
 None
 1.20A 6c71B-1kaqA:
undetectable		 6c71B-1kaqA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 GLY A   9
THR A  10
HIS A  18
SER A 155
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
DND  A 601 (-4.0A)
None
 0.23A 6jmjA-1kaqA:
15.9		 6jmjA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 GLY A   9
THR A  10
SER A 155
SER A 156
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
None
None
 0.96A 6jmjA-1kaqA:
15.9		 6jmjA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 7 GLY A   9
THR A  10
PHE A  11
HIS A  18
SER A 155
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
None
DND  A 601 (-4.0A)
None
 0.34A 6jnhA-1kaqA:
16.0		 6jnhA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 6 GLY A   9
THR A  10
HIS A  18
SER A 155
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
DND  A 601 (-4.0A)
None
 0.27A 6jogA-1kaqA:
15.9		 6jogA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 6 GLY A   9
THR A  10
SER A 155
SER A 156
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
None
None
 0.98A 6jogA-1kaqA:
15.9		 6jogA-1kaqA:
24.88