SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kbl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 11 ILE A  61
GLU A  10
LYS A   3
VAL A 208
PHE A 212
 None
 1.38A 1gx9A-1kblA:
0.0		 1gx9A-1kblA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 7 PHE A 777
PRO A 799
ALA A 782
PHE A 785
 None
 1.23A 1lqtA-1kblA:
undetectable		 1lqtA-1kblA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 7 PHE A 777
PRO A 799
ALA A 782
PHE A 785
 None
 1.22A 1lquA-1kblA:
undetectable		 1lquA-1kblA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 5 LYS A 678
PHE A 626
LEU A 591
LEU A 707
 None
None
None
NH4  A 901 ( 4.3A)
 1.08A 1skxA-1kblA:
0.0		 1skxA-1kblA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 7 HIS A 664
LEU A 669
MET A 578
ILE A 579
 None
 1.08A 1tuvA-1kblA:
undetectable		 1tuvA-1kblA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 8 THR A 105
LEU A 107
THR A 253
VAL A 255
 None
 1.07A 1uyuB-1kblA:
0.0		 1uyuB-1kblA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 10 GLU A 369
GLY A 464
GLY A 462
ILE A 861
LEU A 373
 None
 1.15A 1x7pA-1kblA:
undetectable
1x7pB-1kblA:
2.8		 1x7pA-1kblA:
15.29
1x7pB-1kblA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 LEU A 591
ASN A 592
LEU A 594
GLN A 598
LEU A 619
 None
 0.89A 1zucB-1kblA:
undetectable		 1zucB-1kblA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 LEU A 591
ASN A 592
LEU A 594
GLN A 598
LEU A 619
 None
 1.08A 2aa6A-1kblA:
undetectable		 2aa6A-1kblA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 LYS A 371
ASP A 232
ASP A 228
 None
 0.84A 2br4D-1kblA:
undetectable		 2br4D-1kblA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 PHE A 136
LEU A 109
VAL A  89
VAL A 237
LEU A  26
 None
 1.40A 2hc4A-1kblA:
0.0		 2hc4A-1kblA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 11 LEU A 426
ALA A 456
GLY A 462
ALA A 442
ILE A 445
 None
 1.02A 2idwA-1kblA:
undetectable		 2idwA-1kblA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 LEU A 426
ALA A 456
GLY A 462
ALA A 442
ILE A 445
 None
 0.98A 2nmyB-1kblA:
undetectable		 2nmyB-1kblA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 ILE A 349
ILE A 359
LEU A 376
 None
 0.57A 2prgA-1kblA:
undetectable		 2prgA-1kblA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 5 GLN A 680
PHE A 566
PHE A 626
GLY A 666
 None
 1.09A 2qmzA-1kblA:
0.2
2qmzB-1kblA:
0.2		 2qmzA-1kblA:
14.04
2qmzB-1kblA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 LEU A 426
ALA A 456
GLY A 462
ALA A 442
ILE A 445
 None
 0.90A 2rkfA-1kblA:
undetectable		 2rkfA-1kblA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 LEU A 426
ALA A 456
GLY A 462
ALA A 442
ILE A 445
 None
 0.87A 2rkfB-1kblA:
undetectable		 2rkfB-1kblA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 6 ILE A 676
ARG A 587
LEU A 591
LEU A 669
 None
 1.03A 2rlfA-1kblA:
0.0
2rlfD-1kblA:
0.0		 2rlfA-1kblA:
4.60
2rlfD-1kblA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 THR A 562
LEU A 619
PHE A 602
VAL A 684
MET A 685
 None
 1.44A 2vavK-1kblA:
0.4		 2vavK-1kblA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 7 LEU A 109
LEU A  72
GLU A  73
PRO A 200
 None
 0.95A 2vq5B-1kblA:
0.0		 2vq5B-1kblA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 5 GLN A 293
THR A 292
THR A 453
LEU A 396
 None
 1.35A 2zj0A-1kblA:
2.2		 2zj0A-1kblA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 MET A 306
GLU A 313
ASP A 352
 None
 0.67A 3a25A-1kblA:
undetectable		 3a25A-1kblA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 5 GLN A 293
THR A 292
THR A 453
LEU A 396
 None
 1.34A 3ce6A-1kblA:
2.3		 3ce6A-1kblA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 5 GLN A 293
THR A 292
THR A 453
LEU A 396
 None
 1.31A 3ce6C-1kblA:
2.3		 3ce6C-1kblA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 LEU A 594
GLU A 568
ILE A 572
 None
 0.58A 3czhA-1kblA:
undetectable		 3czhA-1kblA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 LEU A 591
ASN A 592
LEU A 594
GLN A 598
LEU A 619
 None
 0.95A 3d90B-1kblA:
undetectable		 3d90B-1kblA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 10 LEU A 426
ALA A 456
GLY A 462
ALA A 442
ILE A 445
 None
 0.96A 3ekpB-1kblA:
undetectable		 3ekpB-1kblA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 10 ILE A 368
ALA A 370
LEU A 864
ALA A 865
ILE A 359
 None
 1.00A 3falC-1kblA:
undetectable		 3falC-1kblA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 11 ILE A 368
ALA A 370
LEU A 864
ALA A 865
ILE A 359
 None
 0.97A 3fc6A-1kblA:
undetectable		 3fc6A-1kblA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 ASN A 112
MET A 242
PHE A 136
 None
 0.85A 3g4lD-1kblA:
undetectable		 3g4lD-1kblA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 MET A 205
MET A 145
PHE A 212
 None
 1.38A 3gn8A-1kblA:
0.0		 3gn8A-1kblA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 ILE A 368
ALA A 370
LEU A 864
ALA A 865
ILE A 359
 None
 0.96A 3oapA-1kblA:
undetectable		 3oapA-1kblA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 GLU A 279
ALA A 276
GLY A 252
SER A 251
LEU A 273
 None
 1.37A 3ou6D-1kblA:
undetectable		 3ou6D-1kblA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 ARG A 802
ASP A 374
GLN A 375
 None
 0.65A 4azsA-1kblA:
2.1		 4azsA-1kblA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 7 ALA A 757
PHE A 763
ALA A 815
PRO A 824
 None
 0.91A 4du2A-1kblA:
undetectable		 4du2A-1kblA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 8 SER A 839
SER A 840
THR A 767
GLY A 809
 None
 1.00A 4fo4A-1kblA:
10.8		 4fo4A-1kblA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 VAL A 458
GLY A 462
LYS A 340
 None
 0.56A 4k50A-1kblA:
2.3		 4k50A-1kblA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 VAL A 458
GLY A 462
LYS A 340
 None
 0.59A 4k50E-1kblA:
undetectable		 4k50E-1kblA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 VAL A 458
GLY A 462
LYS A 340
 None
 0.58A 4k50I-1kblA:
2.1		 4k50I-1kblA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 8 LEU A 179
LEU A 176
ILE A 156
VAL A 165
 None
 0.62A 4klaA-1kblA:
undetectable		 4klaA-1kblA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 ILE A 368
ALA A 370
LEU A 864
ALA A 865
ILE A 359
 None
 1.01A 4nqaH-1kblA:
undetectable		 4nqaH-1kblA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 ARG A 461
ALA A 398
SER A 469
MET A 463
GLY A 464
 None
 1.26A 4r29A-1kblA:
0.0		 4r29A-1kblA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 ARG A 461
ALA A 398
SER A 469
MET A 463
GLY A 464
 None
 1.13A 4r29B-1kblA:
0.0		 4r29B-1kblA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 GLY A 254
GLY A 252
GLY A 245
ASN A 246
ALA A 256
 None
 1.00A 4uciA-1kblA:
undetectable		 4uciA-1kblA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 GLY A 254
GLY A 252
GLY A 245
ASN A 246
ALA A 256
 None
 1.00A 4uciB-1kblA:
undetectable		 4uciB-1kblA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 VAL A 847
LEU A 849
VAL A 816
 None
 0.57A 4wq4A-1kblA:
2.4		 4wq4A-1kblA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 10 VAL A 700
ILE A 699
TYR A 606
LEU A 609
ILE A 705
 None
 1.37A 5hw8C-1kblA:
undetectable
5hw8H-1kblA:
undetectable		 5hw8C-1kblA:
10.10
5hw8H-1kblA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 6 VAL A 147
ALA A 190
VAL A 186
TYR A 187
 None
 1.00A 5i8fA-1kblA:
0.0		 5i8fA-1kblA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		3 / 3 CYH A 844
LYS A 846
HIS A 845
 None
 1.03A 5js5A-1kblA:
0.5		 5js5A-1kblA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 ASP A 355
GLU A 356
LEU A 373
ALA A 350
ARG A 259
 None
 1.23A 5nd3B-1kblA:
2.0		 5nd3B-1kblA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 ASP A 355
GLU A 356
LEU A 376
ALA A 350
ARG A 259
 None
 1.26A 5nd3B-1kblA:
2.0		 5nd3B-1kblA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 VAL A 354
ASP A 355
GLU A 356
LEU A 373
ARG A 259
 None
 1.17A 5nd3B-1kblA:
2.0		 5nd3B-1kblA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 VAL A 354
ASP A 355
GLU A 356
LEU A 864
ARG A 259
 None
 1.26A 5nd3B-1kblA:
2.0		 5nd3B-1kblA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 LEU A 591
ASN A 592
LEU A 594
GLN A 598
LEU A 619
 None
 1.00A 5uc1B-1kblA:
undetectable		 5uc1B-1kblA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1kbl PYRUVATE PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 7 ASP A 541
GLU A 563
ASP A 620
GLU A 745
 None
None
NH4  A 901 (-3.2A)
NH4  A 901 (-2.8A)
 1.34A 6mn5B-1kblA:
0.0		 6mn5B-1kblA:
6.91