SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 SER A 103
THR A 104
GLU A 136
GLY A 135
 None
 1.31A 1icrA-1kbzA:
0.0
1icrB-1kbzA:
0.0		 1icrA-1kbzA:
25.24
1icrB-1kbzA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 GLU A 136
GLY A 135
SER A 103
THR A 104
 None
 1.32A 1icrA-1kbzA:
0.0
1icrB-1kbzA:
0.0		 1icrA-1kbzA:
25.24
1icrB-1kbzA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 SER A 103
THR A 104
GLU A 136
GLY A 135
 None
 1.30A 1icvC-1kbzA:
0.0
1icvD-1kbzA:
0.0		 1icvC-1kbzA:
25.24
1icvD-1kbzA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 GLU A 136
GLY A 135
SER A 103
THR A 104
 None
 1.32A 1icvC-1kbzA:
undetectable
1icvD-1kbzA:
undetectable		 1icvC-1kbzA:
25.24
1icvD-1kbzA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 GLU A 136
GLY A 135
SER A 103
THR A 104
 None
 1.30A 1kqbA-1kbzA:
undetectable
1kqbB-1kbzA:
undetectable		 1kqbA-1kbzA:
24.12
1kqbB-1kbzA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 ALA A  61
VAL A  59
LEU A  16
ALA A 189
VAL A 154
 None
 1.01A 1sn5B-1kbzA:
undetectable
1sn5D-1kbzA:
undetectable		 1sn5B-1kbzA:
19.32
1sn5D-1kbzA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A  16
ALA A 189
VAL A 154
ALA A  61
VAL A  59
 None
 1.01A 1sn5B-1kbzA:
undetectable
1sn5D-1kbzA:
undetectable		 1sn5B-1kbzA:
19.32
1sn5D-1kbzA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A 246
PHE A 231
VAL A 230
ALA A 163
PHE A 162
 None
 1.47A 2jj8B-1kbzA:
0.3		 2jj8B-1kbzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 9 VAL A  57
ILE A 200
ILE A 148
ALA A  92
ILE A  58
 None
 1.03A 3el0B-1kbzA:
undetectable		 3el0B-1kbzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 LEU A 246
GLN A 174
LEU A 176
GLU A 245
 None
 0.93A 3h5gA-1kbzA:
undetectable
3h5gB-1kbzA:
undetectable		 3h5gA-1kbzA:
7.69
3h5gB-1kbzA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 12 GLY A 211
ASN A 274
ARG A 150
ILE A 148
GLU A 136
 None
 1.29A 4azsA-1kbzA:
2.9		 4azsA-1kbzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 8 ALA A 237
ILE A 239
ALA A 228
PHE A 231
LEU A 241
 None
 1.36A 4v1fA-1kbzA:
undetectable
4v1fB-1kbzA:
undetectable		 4v1fA-1kbzA:
17.28
4v1fB-1kbzA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		5 / 8 ALA A 237
ILE A 239
ALA A 228
PHE A 231
LEU A 241
 None
 1.38A 4v1fA-1kbzA:
undetectable
4v1fB-1kbzA:
undetectable		 4v1fA-1kbzA:
17.28
4v1fB-1kbzA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 7 VAL A  85
ILE A  88
LEU A  16
LEU A   5
 None
 1.01A 4xo7A-1kbzA:
undetectable		 4xo7A-1kbzA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 7 LEU A 279
THR A 187
LEU A 191
THR A 268
 None
 0.85A 4z90A-1kbzA:
0.0
4z90B-1kbzA:
0.0
4z90C-1kbzA:
0.0
4z90D-1kbzA:
0.0
4z90E-1kbzA:
0.0		 4z90A-1kbzA:
19.54
4z90B-1kbzA:
19.54
4z90C-1kbzA:
19.54
4z90D-1kbzA:
19.54
4z90E-1kbzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		4 / 5 GLU A 190
ALA A 156
GLU A  15
GLU A 292
 None
None
MG  A 501 ( 4.0A)
MG  A 501 ( 4.0A)
 1.46A 5dwkC-1kbzA:
undetectable		 5dwkC-1kbzA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		6 / 12 GLY A  10
GLY A   7
VAL A  12
ALA A 193
LEU A  20
THR A 196
 None
 1.49A 5hieC-1kbzA:
undetectable		 5hieC-1kbzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		3 / 3 VAL A  99
GLN A 140
CYH A 143
 None
 0.72A 5icxA-1kbzA:
0.0
5icxE-1kbzA:
undetectable		 5icxA-1kbzA:
21.40
5icxE-1kbzA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1kbz DTDP-GLUCOSE
OXIDOREDUCTASE
(Salmonella
enterica) 		3 / 3 VAL A  99
GLN A 140
CYH A 143
 None
 0.87A 5icxC-1kbzA:
undetectable
5icxF-1kbzA:
undetectable		 5icxC-1kbzA:
21.40
5icxF-1kbzA:
3.83