SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L21E
(Haloarcula
marismortui) 		3 / 3 VAL R  30
ALA R  29
HIS R  90
 None
 0.56A 1q23C-1kc8R:
undetectable		 1q23C-1kc8R:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L21E
(Haloarcula
marismortui) 		3 / 3 VAL R  30
ALA R  29
HIS R  90
 None
 0.56A 1q23H-1kc8R:
undetectable		 1q23H-1kc8R:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L21E
(Haloarcula
marismortui) 		3 / 3 VAL R  30
ALA R  29
HIS R  90
 None
 0.40A 1q23G-1kc8R:
undetectable		 1q23G-1kc8R:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L21E
(Haloarcula
marismortui) 		3 / 3 VAL R  30
ALA R  29
HIS R  90
 None
 0.66A 1q23L-1kc8R:
undetectable		 1q23L-1kc8R:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L21E
(Haloarcula
marismortui) 		3 / 3 VAL R  30
ALA R  29
HIS R  90
 None
 0.55A 1q23J-1kc8R:
undetectable		 1q23J-1kc8R:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1kc8 RIBOSOMAL PROTEIN
L15E
(Haloarcula
marismortui) 		4 / 6 ARG N  64
ASP N 135
ASN N 111
GLU N 130
 None
G  A 135 ( 3.3A)
U  A 134 ( 3.0A)
None
 1.27A 1rjdA-1kc8N:
undetectable		 1rjdA-1kc8N:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1kc8 RIBOSOMAL PROTEIN
L15E
(Haloarcula
marismortui) 		4 / 6 ARG N  64
ASP N 135
ASN N 111
GLU N 130
 None
G  A 135 ( 3.3A)
U  A 134 ( 3.0A)
None
 1.21A 1rjdB-1kc8N:
undetectable		 1rjdB-1kc8N:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1kc8 RIBOSOMAL PROTEIN
L15E
(Haloarcula
marismortui) 		4 / 6 ARG N  64
ASP N 135
ASN N 111
GLU N 130
 None
G  A 135 ( 3.3A)
U  A 134 ( 3.0A)
None
 1.20A 1rjdC-1kc8N:
undetectable		 1rjdC-1kc8N:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 1kc8 RIBOSOMAL PROTEIN
L18
(Haloarcula
marismortui) 		3 / 3 TRP O 139
GLU O 120
TYR O  82
 None
 1.26A 2a3aA-1kc8O:
undetectable		 2a3aA-1kc8O:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 1kc8 RIBOSOMAL PROTEIN
L18
(Haloarcula
marismortui) 		5 / 9 LEU O 186
ARG O  91
LEU O 179
ALA O 122
ALA O  61
 None
 1.06A 2bxcB-1kc8O:
undetectable		 2bxcB-1kc8O:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 1kc8 RIBOSOMAL PROTEIN
L14
(Haloarcula
marismortui) 		6 / 12 ILE L  53
GLY L  11
ARG L  75
ALA L  94
ALA L  95
VAL L  96
 None
G  A1743 ( 3.0A)
None
None
None
None
 1.50A 2oc8A-1kc8L:
undetectable		 2oc8A-1kc8L:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L18
(Haloarcula
marismortui) 		4 / 4 SER O  29
GLY O  30
HIS O 131
ASP O 124
 A  A2415 ( 3.7A)
None
None
None
 1.37A 2oxtC-1kc8O:
undetectable		 2oxtC-1kc8O:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1kc8 RIBOSOMAL PROTEIN
L15E
(Haloarcula
marismortui) 		3 / 3 TRP N  31
VAL N  37
TRP N 128
 None
 1.35A 2xdcE-1kc8N:
undetectable
2xdcF-1kc8N:
undetectable		 2xdcE-1kc8N:
5.82
2xdcF-1kc8N:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1kc8 RIBOSOMAL PROTEIN
L18
(Haloarcula
marismortui) 		4 / 6 LEU O  83
LEU O  90
ARG O 176
LEU O  66
 None
 1.05A 3f33A-1kc8O:
undetectable		 3f33A-1kc8O:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L18E
(Haloarcula
marismortui) 		3 / 3 SER P  82
GLY P  83
THR P  84
 A  A 660 ( 2.8A)
A  A 659 ( 3.9A)
A  A 660 ( 3.4A)
 0.19A 3k9wA-1kc8P:
undetectable		 3k9wA-1kc8P:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1kc8 RIBOSOMAL PROTEIN
L18
(Haloarcula
marismortui) 		6 / 12 LEU O 102
LEU O 136
ILE O 123
ALA O 122
GLU O 120
ALA O  81
 A  A2413 ( 4.6A)
None
None
None
None
None
 1.36A 3mdvB-1kc8O:
undetectable		 3mdvB-1kc8O:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1kc8 RIBOSOMAL PROTEIN
L18
(Haloarcula
marismortui) 		4 / 6 ALA O 122
ILE O 118
LEU O  34
ALA O  92
 None
 0.88A 3r9sA-1kc8O:
undetectable		 3r9sA-1kc8O:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1kc8 RIBOSOMAL PROTEIN
L15E
(Haloarcula
marismortui) 		3 / 3 TRP N  31
VAL N  37
TRP N 128
 None
 1.32A 3zq8A-1kc8N:
undetectable
3zq8B-1kc8N:
undetectable		 3zq8A-1kc8N:
5.82
3zq8B-1kc8N:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L21E
(Haloarcula
marismortui) 		5 / 12 PHE R  52
GLY R  61
ILE R  84
VAL R  73
ASP R  57
 None
 1.12A 4a6dA-1kc8R:
undetectable		 4a6dA-1kc8R:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1kc8 RIBOSOMAL PROTEIN
L21E
(Haloarcula
marismortui) 		5 / 12 PHE R  52
GLY R  61
ILE R  84
VAL R  73
ASP R  57
 None
 1.14A 4a6eA-1kc8R:
undetectable		 4a6eA-1kc8R:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 1kc8 RIBOSOMAL PROTEIN
L14
(Haloarcula
marismortui) 		4 / 4 ALA L  95
VAL L  98
GLY L 106
THR L  24
 None
 1.01A 4ubeA-1kc8L:
undetectable		 4ubeA-1kc8L:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 1kc8 RIBOSOMAL PROTEIN
L15E
(Haloarcula
marismortui) 		5 / 12 ILE N 100
ILE N  67
VAL N  65
VAL N  63
LEU N 133
 A  A1470 ( 4.1A)
None
None
None
None
 1.01A 4y0pA-1kc8N:
undetectable		 4y0pA-1kc8N:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1kc8 RIBOSOMAL PROTEIN
L18E
(Haloarcula
marismortui) 		5 / 12 ASP P  90
ALA P  95
PHE P  81
GLY P  66
SER P  67
 None
None
None
A  A 660 ( 3.7A)
A  A 660 ( 3.2A)
 1.19A 5hfjD-1kc8P:
undetectable		 5hfjD-1kc8P:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1kc8 RIBOSOMAL PROTEIN
L18E
(Haloarcula
marismortui) 		5 / 12 ASP P  90
ALA P  95
PHE P  81
GLY P  66
SER P  67
 None
None
None
A  A 660 ( 3.7A)
A  A 660 ( 3.2A)
 1.27A 5hfjE-1kc8P:
undetectable		 5hfjE-1kc8P:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1kc8 RIBOSOMAL PROTEIN
L18E
(Haloarcula
marismortui) 		4 / 5 ASN P 104
VAL P  29
LEU P  33
SER P  97
 None
 1.32A 6a7pA-1kc8P:
undetectable		 6a7pA-1kc8P:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 1kc8 RIBOSOMAL PROTEIN
L15E
(Haloarcula
marismortui) 		4 / 8 ASP N 135
ASP N 137
HIS N 138
PRO N 139
 G  A 135 ( 3.3A)
A  A 145 ( 3.4A)
C  A 136 ( 4.1A)
C  A 251 ( 4.0A)
 0.84A 6ag0A-1kc8N:
undetectable		 6ag0A-1kc8N:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 1kc8 RIBOSOMAL PROTEIN
L15E
(Haloarcula
marismortui) 		4 / 8 ASP N 135
ASP N 137
HIS N 138
PRO N 139
 G  A 135 ( 3.3A)
A  A 145 ( 3.4A)
C  A 136 ( 4.1A)
C  A 251 ( 4.0A)
 0.88A 6ag0C-1kc8N:
undetectable		 6ag0C-1kc8N:
17.20