SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHX_B_PXLB313_1 (PYRIDOXAL KINASE)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 8	VAL A 199 PHE A 213 HIS A 215 VAL A 197	None	0.99A	3fhxB-1kcmA: undetectable	3fhxB-1kcmA: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQF_B_QPSB951_1 (ALPHA-GLUCAN PHOSPHORYLASE 2, CYTOSOLIC)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 8	GLU A 6 GLU A 113 LYS A 111 ARG A 96	None	0.86A	4bqfB-1kcmA: undetectable	4bqfB-1kcmA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MK4_A_CHDA504_0 (FERROCHELATASE, MITOCHONDRIAL)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 8	ARG A 147 PRO A 12 VAL A 13 GLY A 175	None	0.98A	4mk4A-1kcmA: undetectable	4mk4A-1kcmA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQC_A_51GA600_1 (BIFUNCTIONAL AAC/APH)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	5 / 10	ASP A 119 TYR A 194 GLU A 6 GLU A 124 TYR A 141	None	1.48A	5iqcA-1kcmA: 0.0	5iqcA-1kcmA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQC_B_51GB600_1 (BIFUNCTIONAL AAC/APH)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	5 / 10	ASP A 119 TYR A 194 GLU A 6 GLU A 124 TYR A 141	None	1.45A	5iqcB-1kcmA: 0.0	5iqcB-1kcmA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQD_B_RIOB600_0 (BIFUNCTIONAL AAC/APH)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	5 / 11	ASP A 119 TYR A 194 GLU A 6 GLU A 124 TYR A 141	None	1.49A	5iqdB-1kcmA: 0.0	5iqdB-1kcmA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQG_A_51GA600_1 (BIFUNCTIONAL AAC/APH)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	5 / 10	ASP A 119 TYR A 194 GLU A 6 GLU A 124 TYR A 141	None	1.43A	5iqgA-1kcmA: 0.3	5iqgA-1kcmA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQG_B_51GB600_1 (BIFUNCTIONAL AAC/APH)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	5 / 10	ASP A 119 TYR A 194 GLU A 6 GLU A 124 TYR A 141	None	1.42A	5iqgB-1kcmA: 0.0	5iqgB-1kcmA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQG_C_51GC600_1 (BIFUNCTIONAL AAC/APH)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	5 / 10	ASP A 119 TYR A 194 GLU A 6 GLU A 124 TYR A 141	None	1.46A	5iqgC-1kcmA: 0.0	5iqgC-1kcmA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQG_D_51GD600_1 (BIFUNCTIONAL AAC/APH)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	5 / 10	ASP A 119 TYR A 194 GLU A 6 GLU A 124 TYR A 141	None	1.42A	5iqgD-1kcmA: 0.0	5iqgD-1kcmA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M10_A_NCAA603_0 (CYCLOHEXANONE MONOOXYGENASE FROM THERMOCRISPUM MUNICIPALE)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 5	LEU A 182 ARG A 171 PHE A 230 LEU A 11	None	1.23A	5m10A-1kcmA: undetectable	5m10A-1kcmA: 18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 6	HIS A 127 ARG A 8 GLU A 6 TYR A 194	None	1.10A	5x7pA-1kcmA: 1.2	5x7pA-1kcmA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_B_ACRB1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 6	HIS A 127 ARG A 8 GLU A 6 TYR A 194	None	1.16A	5x7pB-1kcmA: 0.2	5x7pB-1kcmA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7Q_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 6	HIS A 127 ARG A 8 GLU A 6 TYR A 194	None	1.11A	5x7qA-1kcmA: 0.0	5x7qA-1kcmA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7Q_B_ACRB1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 6	HIS A 127 ARG A 8 GLU A 6 TYR A 194	None	1.18A	5x7qB-1kcmA: 0.2	5x7qB-1kcmA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7R_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 6	HIS A 127 ARG A 8 GLU A 6 TYR A 194	None	1.09A	5x7rA-1kcmA: 0.0	5x7rA-1kcmA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7R_B_ACRB1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1kcm	PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA (Mus musculus)	4 / 6	HIS A 127 ARG A 8 GLU A 6 TYR A 194	None	1.17A	5x7rB-1kcmA: 0.0	5x7rB-1kcmA: 12.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3FHX_B_PXLB313_1","PYRIDOXAL KINASE","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"VAL A 199;PHE A 213;HIS A 215;VAL A 197","None","0.99A","3fhxB-1kcmA:undetectable","3fhxB-1kcmA:20.13"],["4BQF_B_QPSB951_1","ALPHA-GLUCAN PHOSPHORYLASE 2, CYTOSOLIC","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"GLU A   6;GLU A 113;LYS A 111;ARG A  96","None","0.86A","4bqfB-1kcmA:undetectable","4bqfB-1kcmA:15.38"],["4MK4_A_CHDA504_0","FERROCHELATASE, MITOCHONDRIAL","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"ARG A 147;PRO A  12;VAL A  13;GLY A 175","None","0.98A","4mk4A-1kcmA:undetectable","4mk4A-1kcmA:20.92"],["5IQC_A_51GA600_1","BIFUNCTIONAL AAC\/APH","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",5,"ASP A 119;TYR A 194;GLU A   6;GLU A 124;TYR A 141","None","1.48A","5iqcA-1kcmA:0.0","5iqcA-1kcmA:23.75"],["5IQC_B_51GB600_1","BIFUNCTIONAL AAC\/APH","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",5,"ASP A 119;TYR A 194;GLU A   6;GLU A 124;TYR A 141","None","1.45A","5iqcB-1kcmA:0.0","5iqcB-1kcmA:23.75"],["5IQD_B_RIOB600_0","BIFUNCTIONAL AAC\/APH","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",5,"ASP A 119;TYR A 194;GLU A   6;GLU A 124;TYR A 141","None","1.49A","5iqdB-1kcmA:0.0","5iqdB-1kcmA:23.75"],["5IQG_A_51GA600_1","BIFUNCTIONAL AAC\/APH","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",5,"ASP A 119;TYR A 194;GLU A   6;GLU A 124;TYR A 141","None","1.43A","5iqgA-1kcmA:0.3","5iqgA-1kcmA:23.75"],["5IQG_B_51GB600_1","BIFUNCTIONAL AAC\/APH","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",5,"ASP A 119;TYR A 194;GLU A   6;GLU A 124;TYR A 141","None","1.42A","5iqgB-1kcmA:0.0","5iqgB-1kcmA:23.75"],["5IQG_C_51GC600_1","BIFUNCTIONAL AAC\/APH","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",5,"ASP A 119;TYR A 194;GLU A   6;GLU A 124;TYR A 141","None","1.46A","5iqgC-1kcmA:0.0","5iqgC-1kcmA:23.75"],["5IQG_D_51GD600_1","BIFUNCTIONAL AAC\/APH","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",5,"ASP A 119;TYR A 194;GLU A   6;GLU A 124;TYR A 141","None","1.42A","5iqgD-1kcmA:0.0","5iqgD-1kcmA:23.75"],["5M10_A_NCAA603_0","CYCLOHEXANONE MONOOXYGENASE FROM THERMOCRISPUM MUNICIPALE","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"LEU A 182;ARG A 171;PHE A 230;LEU A  11","None","1.23A","5m10A-1kcmA:undetectable","5m10A-1kcmA:18.53"],["5X7P_A_ACRA1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"HIS A 127;ARG A   8;GLU A   6;TYR A 194","None","1.10A","5x7pA-1kcmA:1.2","5x7pA-1kcmA:12.03"],["5X7P_B_ACRB1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"HIS A 127;ARG A   8;GLU A   6;TYR A 194","None","1.16A","5x7pB-1kcmA:0.2","5x7pB-1kcmA:12.03"],["5X7Q_A_ACRA1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"HIS A 127;ARG A   8;GLU A   6;TYR A 194","None","1.11A","5x7qA-1kcmA:0.0","5x7qA-1kcmA:12.03"],["5X7Q_B_ACRB1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"HIS A 127;ARG A   8;GLU A   6;TYR A 194","None","1.18A","5x7qB-1kcmA:0.2","5x7qB-1kcmA:12.03"],["5X7R_A_ACRA1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"HIS A 127;ARG A   8;GLU A   6;TYR A 194","None","1.09A","5x7rA-1kcmA:0.0","5x7rA-1kcmA:12.03"],["5X7R_B_ACRB1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1kcm","PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA","Mus musculus",4,"HIS A 127;ARG A   8;GLU A   6;TYR A 194","None","1.17A","5x7rB-1kcmA:0.0","5x7rB-1kcmA:12.03"]]