SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kcv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		6 / 12 TYR L  36
LEU L  96
PHE L  98
ASN H  36
ALA H  97
TRP H 106
 None
 0.73A 1h8sA-1kcvL:
22.6		 1h8sA-1kcvL:
43.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 7 SER H 205
PRO H 203
ALA H 208
ALA H 121
 None
 0.98A 1k5qA-1kcvH:
undetectable
1k5qB-1kcvH:
0.0		 1k5qA-1kcvH:
19.42
1k5qB-1kcvH:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 8 PRO L  40
ASP L  83
SER L 170
ASP L 165
 None
 1.21A 1p7lC-1kcvL:
undetectable		 1p7lC-1kcvL:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 8 PRO L  40
ASP L  83
SER L 170
ASP L 165
 None
 1.21A 1rg9C-1kcvL:
undetectable		 1rg9C-1kcvL:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 8 ALA H  34
ASN H  36
TRP H  48
TYR H  51
 None
 0.34A 1rukH-1kcvH:
28.1
1rukL-1kcvH:
15.3		 1rukH-1kcvH:
75.23
1rukL-1kcvH:
30.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.84A 2aojA-1kcvL:
undetectable		 2aojA-1kcvL:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 7 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.78A 2aojB-1kcvL:
undetectable		 2aojB-1kcvL:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 4 ASN L  28
ALA L  68
GLY L  30
THR L  31
 None
 1.24A 4bboC-1kcvL:
0.0		 4bboC-1kcvL:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1kcv PC282 IMMUNOGLOBULIN
PC282 IMMUNOGLOBULIN
(Mus
musculus;
Mus
musculus) 		4 / 5 GLY H 130
SER H 131
ALA H 132
PHE L 209
 None
 0.91A 4m93B-1kcvH:
22.4
4m93C-1kcvH:
16.3		 4m93B-1kcvH:
62.56
4m93C-1kcvH:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 8 ARG H  67
VAL H  86
ASP H  89
ASP H  90
 None
 0.95A 4xqgA-1kcvH:
undetectable		 4xqgA-1kcvH:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 8 ARG H  67
VAL H  86
ASP H  89
ASP H  90
 None
 0.94A 4xqgB-1kcvH:
undetectable		 4xqgB-1kcvH:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 1kcv PC282 IMMUNOGLOBULIN
(Mus
musculus) 		4 / 7 TYR L  32
SER L  34
TYR L  36
TYR L  49
 None
 0.42A 5aclA-1kcvL:
18.4		 5aclA-1kcvL:
36.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1kcv PC282 IMMUNOGLOBULIN
PC282 IMMUNOGLOBULIN
(Mus
musculus;
Mus
musculus) 		4 / 6 GLY L  57
GLN H   1
TYR H 105
TYR L  55
 None
 1.16A 6ag0A-1kcvL:
undetectable		 6ag0A-1kcvL:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 1kcv PC282 IMMUNOGLOBULIN
PC282 IMMUNOGLOBULIN
(Mus
musculus;
Mus
musculus) 		4 / 6 GLY L  57
GLN H   1
TYR H 105
TYR L  55
 None
 1.19A 6ag0C-1kcvL:
undetectable		 6ag0C-1kcvL:
17.50