SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 4 HIS A 107
VAL A  72
ASN A  73
THR A  74
 None
 1.15A 1dy5A-1kcxA:
undetectable		 1dy5A-1kcxA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 GLU A 232
ILE A 264
PRO A 278
LEU A 326
 None
 0.78A 1hmyA-1kcxA:
undetectable		 1hmyA-1kcxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 9 ASP A 406
GLY A  68
ILE A  66
VAL A  35
ILE A  42
 None
 1.07A 1hxwA-1kcxA:
undetectable		 1hxwA-1kcxA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.15A 1p7lC-1kcxA:
undetectable		 1p7lC-1kcxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.14A 1p7lD-1kcxA:
undetectable		 1p7lD-1kcxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 VAL A 255
ILE A 240
MET A 168
ALA A 260
LEU A 326
 None
 0.97A 1r9oA-1kcxA:
undetectable		 1r9oA-1kcxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.17A 1rg9A-1kcxA:
undetectable		 1rg9A-1kcxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.16A 1rg9B-1kcxA:
undetectable		 1rg9B-1kcxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.15A 1rg9C-1kcxA:
undetectable		 1rg9C-1kcxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.14A 1rg9D-1kcxA:
undetectable		 1rg9D-1kcxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 10 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.43A 1wygA-1kcxA:
undetectable		 1wygA-1kcxA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 9 GLY A 192
ALA A 193
LEU A 191
TRP A 144
LEU A 152
 None
 1.38A 1y7iA-1kcxA:
undetectable		 1y7iA-1kcxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 6 LEU A 196
LEU A 181
LEU A 188
ILE A 242
 None
 0.96A 1z95A-1kcxA:
undetectable		 1z95A-1kcxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 PRO A  67
ILE A 401
VAL A  35
ILE A 411
LEU A  37
 None
 1.20A 1z9hD-1kcxA:
0.0		 1z9hD-1kcxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.28A 2avoB-1kcxA:
undetectable		 2avoB-1kcxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 GLY A  46
ALA A  33
VAL A  65
ILE A  19
ILE A  24
 None
 1.09A 2avsB-1kcxA:
undetectable		 2avsB-1kcxA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.28A 2bpxB-1kcxA:
undetectable		 2bpxB-1kcxA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.30A 2o4kB-1kcxA:
undetectable		 2o4kB-1kcxA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.30A 2o4lB-1kcxA:
undetectable		 2o4lB-1kcxA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
VAL A 403
ILE A  24
 None
 1.49A 2o4lB-1kcxA:
undetectable		 2o4lB-1kcxA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 ASN A  61
ARG A  63
ASP A 456
 None
 0.94A 2qe6A-1kcxA:
undetectable		 2qe6A-1kcxA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 ASN A  61
ARG A  63
ASP A 456
 None
 0.88A 2qe6B-1kcxA:
undetectable		 2qe6B-1kcxA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 11 ALA A 239
VAL A 166
CYH A 248
GLY A 244
ILE A 246
 None
 1.06A 2uxpB-1kcxA:
0.0		 2uxpB-1kcxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 ILE A 391
TYR A 479
LEU A 196
VAL A 197
 None
 0.91A 2w98B-1kcxA:
undetectable		 2w98B-1kcxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 GLY A 332
HIS A 333
ILE A 105
ALA A 280
 None
 0.92A 2x0pA-1kcxA:
0.0		 2x0pA-1kcxA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 PRO A 306
GLU A 221
TYR A 290
 None
 0.80A 2zmbA-1kcxA:
0.0		 2zmbA-1kcxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 9 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.43A 3ax7B-1kcxA:
0.0		 3ax7B-1kcxA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 SER A 114
LEU A 152
LEU A 117
ILE A 141
SER A 119
 None
 1.26A 3iltB-1kcxA:
undetectable
3iltE-1kcxA:
undetectable		 3iltB-1kcxA:
20.00
3iltE-1kcxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.37A 3jw2B-1kcxA:
undetectable		 3jw2B-1kcxA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 LEU A  76
GLY A 357
ASP A  71
VAL A 364
VAL A 365
ILE A 433
 None
 1.18A 3ku1H-1kcxA:
undetectable		 3ku1H-1kcxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 6 GLU A 232
THR A 313
ALA A 260
ALA A 261
 None
 1.18A 3ns1C-1kcxA:
undetectable		 3ns1C-1kcxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 8 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.43A 3ns1L-1kcxA:
undetectable		 3ns1L-1kcxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 TYR A  75
TYR A 167
GLU A 277
 None
 0.88A 3pfgA-1kcxA:
undetectable		 3pfgA-1kcxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 SER A 282
ASP A  71
ASP A 106
 None
 0.88A 3uj7A-1kcxA:
undetectable		 3uj7A-1kcxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 LEU A 116
VAL A 161
VAL A 108
LEU A 152
 None
 0.98A 3v81C-1kcxA:
0.0		 3v81C-1kcxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 5 PHE A 380
GLY A  99
ILE A  66
VAL A 410
 None
 0.88A 3wrkA-1kcxA:
undetectable		 3wrkA-1kcxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 10 LEU A 196
GLY A 332
ASP A  71
GLY A 330
PHE A 392
 None
 1.24A 4bwlC-1kcxA:
8.0		 4bwlC-1kcxA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 ALA A 193
LEU A 196
SER A 136
ILE A 105
ASN A  73
 None
 1.18A 4gh8B-1kcxA:
undetectable		 4gh8B-1kcxA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.29A 4jecA-1kcxA:
undetectable		 4jecA-1kcxA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 HIS A 223
TRP A 295
SER A 304
 None
 1.14A 4lrhD-1kcxA:
undetectable		 4lrhD-1kcxA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 GLY A  46
ALA A  33
VAL A  65
ILE A  19
ILE A  24
 None
 1.09A 4njvD-1kcxA:
undetectable		 4njvD-1kcxA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 LEU A 116
VAL A 161
VAL A 108
LEU A 152
 None
 0.98A 4pwdA-1kcxA:
0.0		 4pwdA-1kcxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 5 LEU A  17
ALA A 407
VAL A  65
ILE A 401
 None
 0.94A 4xe3A-1kcxA:
undetectable		 4xe3A-1kcxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 5 LEU A  17
ALA A 407
VAL A  65
ILE A 401
 None
 0.96A 4xe3B-1kcxA:
undetectable		 4xe3B-1kcxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 4 GLY A  99
LEU A  76
PHE A  89
ILE A 104
 None
 0.86A 4xv2A-1kcxA:
0.0		 4xv2A-1kcxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		6 / 12 LEU A 444
GLY A  62
ALA A  60
VAL A  35
ILE A  25
ILE A 411
 None
 1.35A 5e5kA-1kcxA:
undetectable		 5e5kA-1kcxA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 9 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
 1.24A 5entC-1kcxA:
0.0		 5entC-1kcxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 ALA A  98
ASP A 408
LYS A 398
GLY A  69
SER A 385
 None
 1.31A 5hfjE-1kcxA:
undetectable		 5hfjE-1kcxA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 11 GLY A 354
ALA A 281
VAL A 355
GLU A 360
SER A  85
 None
 1.18A 5i3cC-1kcxA:
undetectable		 5i3cC-1kcxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 MET A 256
GLY A 284
TYR A 316
ILE A 433
ALA A 280
 None
 1.00A 5kvaA-1kcxA:
undetectable		 5kvaA-1kcxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 MET A 256
GLY A 284
TYR A 316
ILE A 433
ALA A 280
 None
 1.00A 5kvaB-1kcxA:
undetectable		 5kvaB-1kcxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 HIS A 289
SER A 292
LYS A 297
 None
 1.41A 5os7A-1kcxA:
0.0		 5os7A-1kcxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		4 / 8 HIS A 124
THR A  93
PHE A  89
ASP A 128
 None
 1.12A 5t8sB-1kcxA:
undetectable		 5t8sB-1kcxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 ILE A 264
VAL A 274
PRO A 272
 None
 0.55A 5uunA-1kcxA:
undetectable		 5uunA-1kcxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		3 / 3 HIS A 289
SER A 292
LYS A 297
 None
 1.41A 6gmdB-1kcxA:
0.0		 6gmdB-1kcxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1
(Mus
musculus) 		5 / 12 THR A  74
GLY A 332
THR A 101
GLY A 100
ASN A 356
 None
 1.20A 6gngA-1kcxA:
undetectable		 6gngA-1kcxA:
23.21