SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 GLY A 174
HIS A 236
MET A 184
LEU A 384
TYR A 356
 None
 1.20A 1fm6D-1kczA:
undetectable		 1fm6D-1kczA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 7 SER A 367
VAL A 383
GLY A 358
THR A 332
 None
 0.79A 1gtnC-1kczA:
undetectable
1gtnD-1kczA:
undetectable		 1gtnC-1kczA:
11.62
1gtnD-1kczA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 4 LEU A 304
PRO A 275
LEU A 291
ARG A 298
 None
 1.33A 1hrkB-1kczA:
1.9		 1hrkB-1kczA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 8 ARG A 298
ALA A 287
GLY A 244
ILE A 243
ILE A 251
 None
 1.09A 1hshD-1kczA:
undetectable		 1hshD-1kczA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 THR A 135
LEU A 139
VAL A 142
 None
 0.55A 1mz9E-1kczA:
undetectable		 1mz9E-1kczA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 GLY A  67
ALA A 137
ASP A 140
ILE A   3
ALA A  98
 None
 1.01A 1sguB-1kczA:
undetectable		 1sguB-1kczA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 ILE A 237
VAL A 239
TYR A 257
ILE A 258
LEU A 204
 None
 1.02A 1z9hD-1kczA:
undetectable		 1z9hD-1kczA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 TRP A 309
ARG A 281
PHE A 319
 None
 1.44A 1zeaH-1kczA:
undetectable
1zeaL-1kczA:
undetectable		 1zeaH-1kczA:
19.33
1zeaL-1kczA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 7 ALA A  77
ARG A  80
TYR A  34
PHE A  43
 None
 1.21A 2ajvH-1kczA:
undetectable
2ajvL-1kczA:
undetectable		 2ajvH-1kczA:
19.37
2ajvL-1kczA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 11 GLY A  67
ALA A 137
ASP A 140
ILE A   3
ALA A  98
 None
 0.99A 2b60B-1kczA:
undetectable		 2b60B-1kczA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 LEU A 291
ALA A 302
LEU A 270
LEU A 304
VAL A 305
 None
 1.00A 2c12C-1kczA:
0.0		 2c12C-1kczA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 4 LEU A 304
PRO A 275
LEU A 291
ARG A 298
 None
 1.34A 2hrcB-1kczA:
undetectable		 2hrcB-1kczA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 4 LEU A  57
ILE A 134
ILE A  97
ALA A  98
 None
 0.78A 2i30A-1kczA:
0.9		 2i30A-1kczA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 8 ILE A 341
ILE A 330
ARG A 281
VAL A 316
ALA A 306
 None
 1.20A 2nniA-1kczA:
undetectable		 2nniA-1kczA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 ARG A 298
ALA A 287
GLY A 244
ILE A 243
 None
 0.77A 2o4nB-1kczA:
undetectable		 2o4nB-1kczA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 4 LEU A 304
PRO A 275
LEU A 291
ARG A 298
 None
 1.34A 2pnjB-1kczA:
undetectable		 2pnjB-1kczA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 4 LEU A 304
PRO A 275
LEU A 291
ARG A 298
 None
 1.45A 2qd2A-1kczA:
undetectable		 2qd2A-1kczA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 5 TYR A 347
ALA A 324
ALA A 355
TYR A 356
 None
 1.15A 3d91A-1kczA:
0.0		 3d91A-1kczA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 ARG A 298
ALA A 287
GLY A 244
ILE A 243
 None
 0.85A 3el9A-1kczA:
undetectable		 3el9A-1kczA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 4 LEU A 304
PRO A 275
LEU A 291
ARG A 298
 None
 1.48A 3hcoA-1kczA:
undetectable		 3hcoA-1kczA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 GLU A 188
ASP A 190
ASP A 230
 None
 0.67A 3jb2A-1kczA:
0.1		 3jb2A-1kczA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 GLU A 294
LEU A 291
ASP A 290
 None
 0.43A 3ko0A-1kczA:
undetectable		 3ko0A-1kczA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 GLU A 294
LEU A 291
ASP A 290
 None
 0.39A 3ko0T-1kczA:
undetectable		 3ko0T-1kczA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 6 ILE A 341
ILE A  53
GLY A 133
VAL A  72
 None
 0.94A 3n3iA-1kczA:
0.0		 3n3iA-1kczA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 9 GLY A 359
GLY A 358
TYR A 356
VAL A 328
GLU A 363
 None
 1.25A 3owxA-1kczA:
undetectable		 3owxA-1kczA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 7 ARG A 298
ALA A 287
GLY A 244
ILE A 243
 None
 0.87A 3spkB-1kczA:
undetectable		 3spkB-1kczA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.87A 3u5kA-1kczA:
0.0		 3u5kA-1kczA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.89A 3u5kC-1kczA:
undetectable		 3u5kC-1kczA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.92A 3u5kD-1kczA:
undetectable		 3u5kD-1kczA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 5 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.97A 4a9jA-1kczA:
0.3		 4a9jA-1kczA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 5 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.92A 4a9jC-1kczA:
0.3		 4a9jC-1kczA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 ILE A 237
ASP A 238
ILE A 197
GLY A 205
 None
MG  A 901 (-2.4A)
None
None
 0.84A 4ac9C-1kczA:
undetectable		 4ac9C-1kczA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 7 GLY A 244
ASP A 277
GLY A 241
VAL A 278
 None
 0.89A 4c5nA-1kczA:
undetectable		 4c5nA-1kczA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 TYR A 240
GLN A 329
TRP A 309
 None
MG  A 901 ( 4.7A)
None
 1.11A 4kn2C-1kczA:
0.0		 4kn2C-1kczA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.81A 4lzrA-1kczA:
undetectable		 4lzrA-1kczA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 10 ARG A 298
ALA A 287
GLY A 244
ILE A 243
ILE A 251
 None
 1.05A 4njuB-1kczA:
undetectable		 4njuB-1kczA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 10 ARG A 298
ALA A 287
GLY A 244
ILE A 243
ILE A 251
 None
 1.04A 4njuD-1kczA:
undetectable		 4njuD-1kczA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 ALA A 377
GLN A 136
GLY A 133
 None
 0.60A 4odoC-1kczA:
undetectable		 4odoC-1kczA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 ILE A 134
GLY A 133
ALA A  70
VAL A  55
ILE A  93
 None
 1.04A 4rvdA-1kczA:
undetectable		 4rvdA-1kczA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 ILE A 134
GLY A 133
ALA A  70
VAL A  55
ILE A  93
 None
 1.04A 4rvgA-1kczA:
undetectable		 4rvgA-1kczA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 GLY A 394
GLY A 388
GLY A  14
ASN A 362
ALA A 385
 None
OCS  A 361 ( 3.5A)
OCS  A 361 ( 3.4A)
None
None
 1.01A 4uciA-1kczA:
undetectable		 4uciA-1kczA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 GLY A 394
GLY A 388
GLY A  14
ASN A 362
ALA A 385
 None
OCS  A 361 ( 3.5A)
OCS  A 361 ( 3.4A)
None
None
 1.01A 4uciB-1kczA:
undetectable		 4uciB-1kczA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 GLU A 294
ASP A 290
ARG A 289
ARG A 292
 None
 0.86A 4uhxA-1kczA:
1.8		 4uhxA-1kczA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 11 ASP A  68
GLN A 136
ALA A 137
VAL A 370
ILE A 397
 None
 1.38A 4uuuA-1kczA:
0.0
4uuuB-1kczA:
0.0		 4uuuA-1kczA:
17.07
4uuuB-1kczA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 11 ASN A 339
ILE A 138
THR A 107
GLU A 114
THR A 135
 None
 1.31A 4xt7A-1kczA:
undetectable		 4xt7A-1kczA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 ARG A 131
ASN A 340
ASP A 315
 None
 0.57A 5gwxA-1kczA:
undetectable		 5gwxA-1kczA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 GLY A 174
HIS A 236
MET A 184
LEU A 384
TYR A 356
 None
 1.20A 5ji0D-1kczA:
undetectable		 5ji0D-1kczA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 GLU A 273
LEU A 304
GLY A 241
ALA A 287
PHE A 319
 MG  A 901 (-2.8A)
None
None
None
None
 1.29A 5kc4A-1kczA:
0.0		 5kc4A-1kczA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 10 ARG A 298
ALA A 287
GLY A 244
ILE A 243
ILE A 251
 None
 0.92A 5kr1A-1kczA:
undetectable		 5kr1A-1kczA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 THR A 360
PRO A 333
ASP A 334
 OCS  A 361 ( 3.3A)
None
None
 0.94A 5l8dB-1kczA:
0.0		 5l8dB-1kczA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		4 / 8 ILE A   3
ILE A 134
ALA A 137
ILE A 138
 None
 0.60A 5mvmA-1kczA:
undetectable
5mvmB-1kczA:
undetectable		 5mvmA-1kczA:
16.55
5mvmB-1kczA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 THR A 360
PRO A 333
ASP A 334
 OCS  A 361 ( 3.3A)
None
None
 0.94A 5mwuB-1kczA:
0.0		 5mwuB-1kczA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 VAL A   4
VAL A  58
GLN A  63
 None
 0.69A 5qglA-1kczA:
undetectable		 5qglA-1kczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 VAL A   4
VAL A  58
GLN A  63
 None
 0.71A 5qhgA-1kczA:
undetectable		 5qhgA-1kczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 GLY A 337
ASN A 340
ARG A 125
 None
 0.78A 5w7bD-1kczA:
undetectable		 5w7bD-1kczA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		5 / 12 GLY A 354
ILE A 374
GLY A 379
ALA A 344
ALA A 342
 None
 1.08A 6c2mD-1kczA:
undetectable		 6c2mD-1kczA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1kcz BETA-METHYLASPARTASE
(Clostridium
tetanomorphum) 		3 / 3 GLY A 161
ASP A 156
ILE A 154
 None
 0.58A 6dgxB-1kczA:
undetectable		 6dgxB-1kczA:
12.38