SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ASP A 184
VAL A 177
GLY A 180
GLY A 179
 None
 0.68A 1ekjE-1keaA:
undetectable
1ekjF-1keaA:
undetectable		 1ekjE-1keaA:
18.99
1ekjF-1keaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 VAL A  53
GLU A  42
LEU A  44
ARG A  46
 None
 1.11A 1s8fB-1keaA:
undetectable		 1s8fB-1keaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PHE A 155
ALA A 168
VAL A 143
LEU A 189
LEU A 176
 None
 1.27A 3s79A-1keaA:
0.0		 3s79A-1keaA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ARG A 109
GLY A 107
ILE A 103
GLU A  68
 ACT  A3004 (-4.0A)
None
None
ZN  A1001 (-2.5A)
 0.91A 4g0vA-1keaA:
undetectable		 4g0vA-1keaA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A  32
HIS A  52
LEU A  45
 None
 0.80A 5axdC-1keaA:
undetectable		 5axdC-1keaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 ILE A  43
LEU A  44
ILE A  40
ILE A  70
SER A  76
 None
 1.30A 5numA-1keaA:
undetectable		 5numA-1keaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LEU A 134
LEU A 187
ARG A  30
 None
 0.68A 6fgdA-1keaA:
undetectable		 6fgdA-1keaA:
18.03