SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ken'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		5 / 12 LEU H 145
VAL H 170
GLY H 164
VAL H 190
VAL H 188
 None
 0.93A 2ieoB-1kenH:
undetectable		 2ieoB-1kenH:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		3 / 3 TYR H 182
GLY H 151
PHE H 153
 None
 0.72A 2m2pB-1kenH:
undetectable		 2m2pB-1kenH:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		5 / 11 LEU H 145
VAL H 170
GLY H 164
VAL H 190
VAL H 188
 None
 0.97A 2nnpB-1kenH:
undetectable		 2nnpB-1kenH:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		3 / 3 PRO H   9
LEU H 116
ARG H  39
 None
 0.76A 3aqiB-1kenH:
undetectable		 3aqiB-1kenH:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		5 / 11 VAL H 118
LEU H  11
PRO H   9
SER H   7
THR H 114
 None
 1.34A 3bjwE-1kenH:
undetectable		 3bjwE-1kenH:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		5 / 12 LEU H   4
GLY H  32
ALA H  98
ASN H  58
GLY H  56
 None
 0.99A 4n09A-1kenH:
undetectable		 4n09A-1kenH:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		4 / 5 GLU H 155
PHE H 153
HIS H 206
THR H 117
 None
 1.08A 6b58A-1kenH:
0.0		 6b58A-1kenH:
15.92