SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_E_FUAE706_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1kfa	MONOCLONAL ANTIBODY HEAVY CHAIN (Mus musculus)	5 / 10	THR H 97 SER H 35 PHE H 59 VAL H 64 VAL H 70	None	1.46A	1q23E-1kfaH: 0.0	1q23E-1kfaH: 20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_A_5FWA601_1 (BETA-1 ADRENERGIC RECEPTOR)	1kfa	MONOCLONAL ANTIBODY HEAVY CHAIN (Mus musculus)	5 / 12	VAL H 176 VAL H 194 SER H 192 ASN H 209 ASN H 168	None	1.39A	2y03A-1kfaH: undetectable	2y03A-1kfaH: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_B_5FWB601_1 (BETA-1 ADRENERGIC RECEPTOR)	1kfa	MONOCLONAL ANTIBODY HEAVY CHAIN (Mus musculus)	5 / 12	VAL H 176 VAL H 194 SER H 192 ASN H 209 ASN H 168	None	1.42A	2y03B-1kfaH: undetectable	2y03B-1kfaH: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NYA_A_JTZA1203_1 (BETA-2 ADRENERGIC RECEPTOR, LYSOZYME)	1kfa	MONOCLONAL ANTIBODY HEAVY CHAIN (Mus musculus)	5 / 12	VAL H 176 VAL H 194 SER H 192 ASN H 209 ASN H 168	None	1.32A	3nyaA-1kfaH: undetectable	3nyaA-1kfaH: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LDO_A_ALEA1402_1 (LYSOZYME, BETA-2 ADRENERGIC RECEPTOR)	1kfa	MONOCLONAL ANTIBODY HEAVY CHAIN (Mus musculus)	5 / 10	VAL H 176 VAL H 194 SER H 192 ASN H 209 ASN H 168	None	1.48A	4ldoA-1kfaH: undetectable	4ldoA-1kfaH: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECM_D_LEUD602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	1kfa	MONOCLONAL ANTIBODY HEAVY CHAIN (Mus musculus)	4 / 7	ALA H 92 THR H 91 VAL H 117 GLU H 89	None	0.72A	5ecmD-1kfaH: 0.0	5ecmD-1kfaH: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA606_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	1kfa	MONOCLONAL ANTIBODY HEAVY CHAIN (Mus musculus)	4 / 5	GLU H 161 PHE H 159 HIS H 212 THR H 118	None	1.16A	6b58A-1kfaH: 0.0	6b58A-1kfaH: 16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7M_B_68HB405_0 (BETA-1 ADRENERGIC RECEPTOR)	1kfa	MONOCLONAL ANTIBODY HEAVY CHAIN (Mus musculus)	5 / 12	VAL H 176 VAL H 194 SER H 192 ASN H 209 ASN H 168	None	1.46A	6h7mB-1kfaH: undetectable	6h7mB-1kfaH: 17.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q23_E_FUAE706_1","CHLORAMPHENICOL ACETYLTRANSFERASE","1kfa","MONOCLONAL ANTIBODY HEAVY CHAIN","Mus musculus",5,"THR H  97;SER H  35;PHE H  59;VAL H  64;VAL H  70","None","1.46A","1q23E-1kfaH:0.0","1q23E-1kfaH:20.33"],["2Y03_A_5FWA601_1","BETA-1 ADRENERGIC RECEPTOR","1kfa","MONOCLONAL ANTIBODY HEAVY CHAIN","Mus musculus",5,"VAL H 176;VAL H 194;SER H 192;ASN H 209;ASN H 168","None","1.39A","2y03A-1kfaH:undetectable","2y03A-1kfaH:18.85"],["2Y03_B_5FWB601_1","BETA-1 ADRENERGIC RECEPTOR","1kfa","MONOCLONAL ANTIBODY HEAVY CHAIN","Mus musculus",5,"VAL H 176;VAL H 194;SER H 192;ASN H 209;ASN H 168","None","1.42A","2y03B-1kfaH:undetectable","2y03B-1kfaH:18.85"],["3NYA_A_JTZA1203_1","BETA-2 ADRENERGIC RECEPTOR, LYSOZYME","1kfa","MONOCLONAL ANTIBODY HEAVY CHAIN","Mus musculus",5,"VAL H 176;VAL H 194;SER H 192;ASN H 209;ASN H 168","None","1.32A","3nyaA-1kfaH:undetectable","3nyaA-1kfaH:18.46"],["4LDO_A_ALEA1402_1","LYSOZYME, BETA-2 ADRENERGIC RECEPTOR","1kfa","MONOCLONAL ANTIBODY HEAVY CHAIN","Mus musculus",5,"VAL H 176;VAL H 194;SER H 192;ASN H 209;ASN H 168","None","1.48A","4ldoA-1kfaH:undetectable","4ldoA-1kfaH:19.47"],["5ECM_D_LEUD602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","1kfa","MONOCLONAL ANTIBODY HEAVY CHAIN","Mus musculus",4,"ALA H  92;THR H  91;VAL H 117;GLU H  89","None","0.72A","5ecmD-1kfaH:0.0","5ecmD-1kfaH:16.67"],["6B58_A_ACTA606_0","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","1kfa","MONOCLONAL ANTIBODY HEAVY CHAIN","Mus musculus",4,"GLU H 161;PHE H 159;HIS H 212;THR H 118","None","1.16A","6b58A-1kfaH:0.0","6b58A-1kfaH:16.46"],["6H7M_B_68HB405_0","BETA-1 ADRENERGIC RECEPTOR","1kfa","MONOCLONAL ANTIBODY HEAVY CHAIN","Mus musculus",5,"VAL H 176;VAL H 194;SER H 192;ASN H 209;ASN H 168","None","1.46A","6h7mB-1kfaH:undetectable","6h7mB-1kfaH:17.29"]]