SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FEM_A_REAA184_1
(RETINOL BINDING
PROTEIN)		 1kfr HEMOGLOBIN
(Paramphistomum
epiclitum) 		5 / 10 VAL A  18
PHE A 108
MET A 143
LEU A  78
HIS A  98
 None
HEM  A 148 (-4.2A)
HEM  A 148 (-3.7A)
None
HEM  A 148 (-3.3A)
 1.43A 1femA-1kfrA:
undetectable		 1femA-1kfrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1kfr HEMOGLOBIN
(Paramphistomum
epiclitum) 		4 / 8 SER A 110
PHE A 115
ALA A  31
LEU A  70
 None
HEM  A 148 (-4.8A)
None
HEM  A 148 (-4.6A)
 1.15A 2bxkA-1kfrA:
3.2		 2bxkA-1kfrA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1kfr HEMOGLOBIN
(Paramphistomum
epiclitum) 		5 / 10 PHE A 119
TYR A 118
THR A  71
ILE A  74
VAL A  75
 None
 1.49A 2qboA-1kfrA:
undetectable		 2qboA-1kfrA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 1kfr HEMOGLOBIN
(Paramphistomum
epiclitum) 		4 / 5 THR A  71
ILE A  74
PHE A 119
LEU A  14
 None
 1.18A 3tf1A-1kfrA:
undetectable		 3tf1A-1kfrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 1kfr HEMOGLOBIN
(Paramphistomum
epiclitum) 		4 / 6 TYR A  66
TYR A  32
ASP A  61
HIS A  52
 HEM  A 148 (-4.0A)
None
None
None
 1.29A 5ov9A-1kfrA:
undetectable		 5ov9A-1kfrA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 1kfr HEMOGLOBIN
(Paramphistomum
epiclitum) 		4 / 7 TYR A  66
TYR A  32
ASP A  61
HIS A  52
 HEM  A 148 (-4.0A)
None
None
None
 1.23A 5ov9B-1kfrA:
undetectable		 5ov9B-1kfrA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1kfr HEMOGLOBIN
(Paramphistomum
epiclitum) 		5 / 9 ALA A 131
GLU A 127
GLY A  15
HIS A  17
LEU A  14
 None
 1.48A 5wgqA-1kfrA:
0.5		 5wgqA-1kfrA:
18.84