SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 0.98A 1dmiA-1kfuL:
0.0
1dmiB-1kfuL:
0.0		 1dmiA-1kfuL:
21.56
1dmiB-1kfuL:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 PRO L 159
PHE L 167
SER L 178
ALA L 186
ALA L 184
 None
 0.92A 1nw5A-1kfuL:
undetectable		 1nw5A-1kfuL:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 5 ALA L 630
TYR L 611
ILE L 610
ASP L 615
 None
 1.14A 1upfC-1kfuL:
undetectable		 1upfC-1kfuL:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 LEU L  45
GLN L  47
PHE L  46
PHE L 131
 None
 1.05A 1v55P-1kfuL:
undetectable
1v55W-1kfuL:
undetectable		 1v55P-1kfuL:
16.26
1v55W-1kfuL:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 6 LEU L  45
GLN L  47
PHE L  46
PHE L 131
 None
 1.12A 2einP-1kfuL:
undetectable
2einW-1kfuL:
0.0		 2einP-1kfuL:
16.26
2einW-1kfuL:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 ARG L 337
GLU L 470
SER L 241
 None
 0.94A 2xkkA-1kfuL:
undetectable
2xkkC-1kfuL:
undetectable		 2xkkA-1kfuL:
22.71
2xkkC-1kfuL:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 7 ILE L 604
LEU L 672
PHE L 673
MET L 583
LEU L 520
 None
 1.23A 3adxA-1kfuL:
0.0		 3adxA-1kfuL:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 6 LEU L  45
GLN L  47
PHE L  46
PHE L 131
 None
 1.01A 3ag1C-1kfuL:
0.0
3ag1J-1kfuL:
0.0		 3ag1C-1kfuL:
16.26
3ag1J-1kfuL:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.95A 3dqtA-1kfuL:
undetectable
3dqtB-1kfuL:
0.1		 3dqtA-1kfuL:
18.87
3dqtB-1kfuL:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.94A 3jx1A-1kfuL:
0.0
3jx1B-1kfuL:
0.0		 3jx1A-1kfuL:
20.55
3jx1B-1kfuL:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU L 408
PHE L 502
ILE L 211
PHE L 497
LEU L 472
 None
 1.23A 3ko0A-1kfuL:
6.6
3ko0B-1kfuL:
6.7
3ko0C-1kfuL:
3.8
3ko0D-1kfuL:
3.7		 3ko0A-1kfuL:
11.01
3ko0B-1kfuL:
11.01
3ko0C-1kfuL:
11.01
3ko0D-1kfuL:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU L 408
PHE L 502
ILE L 211
PHE L 497
LEU L 472
 None
 1.20A 3ko0K-1kfuL:
0.0
3ko0L-1kfuL:
6.6
3ko0S-1kfuL:
0.0
3ko0T-1kfuL:
3.8		 3ko0K-1kfuL:
11.01
3ko0L-1kfuL:
11.01
3ko0S-1kfuL:
11.01
3ko0T-1kfuL:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU L 472
LEU L 408
PHE L 502
ILE L 211
PHE L 497
 None
 1.23A 3ko0K-1kfuL:
0.0
3ko0L-1kfuL:
6.6
3ko0M-1kfuL:
0.0
3ko0N-1kfuL:
3.8		 3ko0K-1kfuL:
11.01
3ko0L-1kfuL:
11.01
3ko0M-1kfuL:
11.01
3ko0N-1kfuL:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU L 408
PHE L 502
ILE L 211
PHE L 497
LEU L 472
 None
 1.22A 3ko0M-1kfuL:
0.0
3ko0N-1kfuL:
3.8
3ko0O-1kfuL:
3.7
3ko0P-1kfuL:
3.8		 3ko0M-1kfuL:
11.01
3ko0N-1kfuL:
11.01
3ko0O-1kfuL:
11.01
3ko0P-1kfuL:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 LEU L 281
ASP L 308
ARG L 312
THR L 316
 None
 1.23A 3mbgA-1kfuL:
0.0
3mbgB-1kfuL:
0.0		 3mbgA-1kfuL:
10.30
3mbgB-1kfuL:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 1.04A 3n5tA-1kfuL:
undetectable
3n5tB-1kfuL:
0.1		 3n5tA-1kfuL:
21.56
3n5tB-1kfuL:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.87A 3nlrA-1kfuL:
undetectable
3nlrB-1kfuL:
0.0		 3nlrA-1kfuL:
20.55
3nlrB-1kfuL:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.91A 3nlyA-1kfuL:
0.0
3nlyB-1kfuL:
0.1		 3nlyA-1kfuL:
20.98
3nlyB-1kfuL:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.92A 3rqlA-1kfuL:
undetectable
3rqlB-1kfuL:
0.0		 3rqlA-1kfuL:
20.98
3rqlB-1kfuL:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 GLY L 363
GLN L 145
GLU L 148
ARG L 416
 None
 1.04A 3s3nA-1kfuL:
undetectable		 3s3nA-1kfuL:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.91A 4a97C-1kfuL:
0.0		 4a97C-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.80A 4a97D-1kfuL:
0.0		 4a97D-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.79A 4a97G-1kfuL:
0.0		 4a97G-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.75A 4a97H-1kfuL:
0.3		 4a97H-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 475
VAL L 409
ILE L 499
GLU L 460
 None
 0.79A 4a97I-1kfuL:
0.0		 4a97I-1kfuL:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.91A 4capA-1kfuL:
0.0
4capB-1kfuL:
0.0		 4capA-1kfuL:
20.98
4capB-1kfuL:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 0.78A 4cx7A-1kfuL:
0.0
4cx7B-1kfuL:
0.0		 4cx7A-1kfuL:
20.06
4cx7B-1kfuL:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 0.72A 4cx7C-1kfuL:
undetectable
4cx7D-1kfuL:
0.0		 4cx7C-1kfuL:
20.06
4cx7D-1kfuL:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 ASN L 451
ASN L 379
THR L 380
TRP L 382
 None
 1.01A 4d1yA-1kfuL:
undetectable
4d1yB-1kfuL:
undetectable		 4d1yA-1kfuL:
12.66
4d1yB-1kfuL:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.88A 4d32A-1kfuL:
undetectable
4d32B-1kfuL:
undetectable		 4d32A-1kfuL:
20.98
4d32B-1kfuL:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.98A 4k5jA-1kfuL:
undetectable
4k5jB-1kfuL:
undetectable		 4k5jA-1kfuL:
20.91
4k5jB-1kfuL:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU L 232
ALA L 212
ILE L 284
LEU L 116
GLY L 322
 None
 1.18A 4l9qB-1kfuL:
0.0		 4l9qB-1kfuL:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 6 MET L 622
GLU L 626
GLU L 633
GLU L 632
 None
 1.42A 4r87H-1kfuL:
0.0		 4r87H-1kfuL:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 MET L 622
GLU L 626
GLU L 633
GLU L 632
 None
 1.29A 4r87J-1kfuL:
0.0
4r87L-1kfuL:
0.0		 4r87J-1kfuL:
14.85
4r87L-1kfuL:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 11 LEU L 166
ASP L 104
GLN L  99
ALA L 101
ILE L 111
 None
 1.30A 4uuuA-1kfuL:
0.0
4uuuB-1kfuL:
0.0		 4uuuA-1kfuL:
11.31
4uuuB-1kfuL:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 11 LEU L 166
ASP L 104
GLN L  99
ALA L 101
ILE L 111
 None
 1.28A 4uuuB-1kfuL:
undetectable		 4uuuB-1kfuL:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.93A 4v3yA-1kfuL:
0.0
4v3yB-1kfuL:
0.0		 4v3yA-1kfuL:
20.98
4v3yB-1kfuL:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 12 ASP L 330
HIS L 334
PHE L 328
ILE L 282
ALA L 269
 None
 1.31A 4wh5A-1kfuL:
0.0		 4wh5A-1kfuL:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.92A 5adlA-1kfuL:
0.0
5adlB-1kfuL:
undetectable		 5adlA-1kfuL:
20.91
5adlB-1kfuL:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 1.00A 5fj3A-1kfuL:
undetectable
5fj3B-1kfuL:
undetectable		 5fj3A-1kfuL:
20.91
5fj3B-1kfuL:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 GLY L 198
GLY L 203
PHE L 204
LEU L 338
 None
 0.81A 5izfA-1kfuL:
undetectable		 5izfA-1kfuL:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 0.90A 5uo7A-1kfuL:
0.0
5uo7B-1kfuL:
0.0		 5uo7A-1kfuL:
20.66
5uo7B-1kfuL:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 6 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 1.04A 5uo8A-1kfuL:
0.0
5uo8B-1kfuL:
0.0		 5uo8A-1kfuL:
21.13
5uo8B-1kfuL:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 0.99A 5vv7A-1kfuL:
undetectable
5vv7B-1kfuL:
undetectable		 5vv7A-1kfuL:
20.91
5vv7B-1kfuL:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 1.03A 5vvnA-1kfuL:
undetectable
5vvnB-1kfuL:
undetectable		 5vvnA-1kfuL:
20.91
5vvnB-1kfuL:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 LEU L  45
GLN L  47
PHE L  46
PHE L 131
 None
 0.92A 5z85C-1kfuL:
undetectable
5z85J-1kfuL:
0.0		 5z85C-1kfuL:
16.26
5z85J-1kfuL:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 LEU L  45
GLN L  47
PHE L  46
PHE L 131
 None
 0.94A 5zcqP-1kfuL:
0.0
5zcqW-1kfuL:
0.0		 5zcqP-1kfuL:
16.26
5zcqW-1kfuL:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 TYR L 146
HIS L 415
MET L 422
 None
 1.16A 6af6A-1kfuL:
0.0		 6af6A-1kfuL:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 0.96A 6av6A-1kfuL:
0.0
6av6B-1kfuL:
0.0		 6av6A-1kfuL:
7.16
6av6B-1kfuL:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE L 502
GLU L 339
SER L 236
ARG L 500
 None
 1.01A 6av6C-1kfuL:
0.0
6av6D-1kfuL:
0.0		 6av6C-1kfuL:
7.16
6av6D-1kfuL:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 SER L 236
ARG L 500
PHE L 502
GLU L 339
 None
 1.00A 6av7A-1kfuL:
undetectable
6av7B-1kfuL:
undetectable		 6av7A-1kfuL:
7.16
6av7B-1kfuL:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 7 VAL L 152
PHE L 167
PHE L 207
LEU L 107
 None
 1.11A 6aycA-1kfuL:
2.0		 6aycA-1kfuL:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 TYR L 215
PRO L 220
LEU L 217
 None
 0.93A 6beoA-1kfuL:
undetectable		 6beoA-1kfuL:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 SER L 241
SER L 336
ALA L 199
 None
 0.48A 6dwnC-1kfuL:
0.2		 6dwnC-1kfuL:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 6 ALA L 231
GLY L 210
THR L 208
ILE L 120
 None
 0.75A 6f8cA-1kfuL:
undetectable		 6f8cA-1kfuL:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		5 / 10 PHE L 139
ALA L 184
TYR L 185
PHE L 143
PHE L 207
 None
 1.25A 6hu9C-1kfuL:
undetectable		 6hu9C-1kfuL:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens) 		4 / 5 LEU L  45
GLN L  47
PHE L  46
PHE L 131
 None
 1.12A 6nmpP-1kfuL:
0.0
6nmpW-1kfuL:
0.0		 6nmpP-1kfuL:
16.26
6nmpW-1kfuL:
6.33