SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kgd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens) 		5 / 9 ASN A 891
GLU A 896
ARG A 899
ILE A 898
ILE A 750
 None
 1.36A 1aj6A-1kgdA:
undetectable		 1aj6A-1kgdA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens) 		4 / 6 LEU A 901
ILE A 829
ARG A 747
ILE A 750
 None
 0.96A 2q8hA-1kgdA:
undetectable		 2q8hA-1kgdA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens) 		3 / 3 VAL A 832
ASP A 831
GLU A 802
 None
None
FMT  A 601 ( 4.4A)
 0.62A 2qeuA-1kgdA:
undetectable		 2qeuA-1kgdA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens) 		3 / 3 VAL A 832
ASP A 831
GLU A 802
 None
None
FMT  A 601 ( 4.4A)
 0.63A 2qeuC-1kgdA:
0.0		 2qeuC-1kgdA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens) 		4 / 5 LEU A 740
GLY A 741
PHE A 851
PHE A 885
 None
 1.08A 3smtA-1kgdA:
undetectable		 3smtA-1kgdA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens) 		3 / 3 LYS A 757
THR A 753
ILE A 894
 None
 0.94A 4e0fB-1kgdA:
0.0		 4e0fB-1kgdA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens) 		4 / 6 LEU A 740
PHE A 885
ASP A 886
HIS A 883
 None
 1.23A 5om3A-1kgdA:
0.0
5om3B-1kgdA:
0.0		 5om3A-1kgdA:
20.71
5om3B-1kgdA:
12.42