SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 8 ILE A  51
LEU A  80
GLU A  11
ALA A  15
VAL A   7
 None
 1.17A 1a29A-1kgsA:
undetectable		 1a29A-1kgsA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 9 ILE A  51
LEU A  80
GLU A  11
ALA A  15
VAL A   7
 None
 1.25A 1ctrA-1kgsA:
undetectable		 1ctrA-1kgsA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		4 / 4 ILE A 159
LEU A 134
VAL A 203
ILE A 212
 None
 0.86A 1fm6D-1kgsA:
0.0		 1fm6D-1kgsA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 11 LEU A  56
GLY A  38
VAL A  77
ILE A  51
VAL A  50
 None
 1.21A 1phgA-1kgsA:
undetectable		 1phgA-1kgsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 ILE A 211
ILE A 212
ALA A 222
LEU A 134
LEU A 152
 None
 1.08A 1xzxX-1kgsA:
0.0		 1xzxX-1kgsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		3 / 3 LEU A  80
LEU A 117
PHE A 105
 None
 0.71A 2pgrA-1kgsA:
undetectable		 2pgrA-1kgsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		3 / 3 ASP A  16
ARG A  12
ALA A  15
 None
 0.54A 3mbgC-1kgsA:
undetectable		 3mbgC-1kgsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		4 / 8 GLY A  96
ALA A  97
GLY A  61
THR A  81
 None
 0.62A 3so9A-1kgsA:
undetectable		 3so9A-1kgsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		4 / 8 LEU A  22
VAL A  29
LEU A 101
LEU A  78
 None
 0.95A 4l1xA-1kgsA:
1.2		 4l1xA-1kgsA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		3 / 3 ASN A  94
ASP A  85
ASP A  98
 None
 0.76A 4obwD-1kgsA:
undetectable		 4obwD-1kgsA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		3 / 3 THR A  19
HIS A  59
LEU A  56
 None
 0.88A 5axdC-1kgsA:
6.7		 5axdC-1kgsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		4 / 5 LEU A 110
LEU A  14
THR A  81
PRO A  57
 None
 1.06A 6ew0F-1kgsA:
0.8		 6ew0F-1kgsA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		4 / 6 LEU A 110
LEU A  14
THR A  81
PRO A  57
 None
 1.06A 6ew0G-1kgsA:
0.2		 6ew0G-1kgsA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1kgs DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		3 / 3 LEU A  52
ASN A  74
LEU A 117
 None
 0.62A 6exiA-1kgsA:
6.1		 6exiA-1kgsA:
15.11