SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1khc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.03A 1v54A-1khcA:
undetectable
1v54J-1khcA:
undetectable
1v54A-1khcA:
13.81
1v54J-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.94A 1v54N-1khcA:
undetectable
1v54W-1khcA:
0.0
1v54N-1khcA:
13.81
1v54W-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.00A 2dyrN-1khcA:
undetectable
2dyrW-1khcA:
undetectable
2dyrN-1khcA:
13.81
2dyrW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.06A 2dysA-1khcA:
undetectable
2dysJ-1khcA:
undetectable
2dysA-1khcA:
13.81
2dysJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.96A 2dysN-1khcA:
undetectable
2dysW-1khcA:
undetectable
2dysN-1khcA:
13.81
2dysW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.06A 2eijA-1khcA:
undetectable
2eijJ-1khcA:
undetectable
2eijA-1khcA:
13.81
2eijJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.04A 2eikA-1khcA:
undetectable
2eikJ-1khcA:
undetectable
2eikA-1khcA:
13.81
2eikJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.01A 2eilA-1khcA:
undetectable
2eilJ-1khcA:
undetectable
2eilA-1khcA:
13.81
2eilJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.04A 2eimJ-1khcA:
undetectable
2eimJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.96A 2eimW-1khcA:
0.0
2eimW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.99A 2einN-1khcA:
undetectable
2einW-1khcA:
undetectable
2einN-1khcA:
13.81
2einW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.10A 2zxwA-1khcA:
undetectable
2zxwJ-1khcA:
undetectable
2zxwA-1khcA:
13.81
2zxwJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 8 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.89A 3abmN-1khcA:
undetectable
3abmW-1khcA:
undetectable
3abmN-1khcA:
13.81
3abmW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.10A 3ag1J-1khcA:
undetectable
3ag1J-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.02A 3ag2J-1khcA:
undetectable
3ag2J-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.18A 3ag4J-1khcA:
undetectable
3ag4J-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 MET A 309
LEU A 340
LEU A 287
PHE A 271
None
1.12A 3nk2X-1khcA:
undetectable
3nk2X-1khcA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RNJ_A_EDTA1_0
(BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR
1-ASSOCIATED PROTEIN
2)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 4 LYS A 315
ARG A 319
LEU A 235
ASP A 234
UNX  A 177 (-2.8A)
UNX  A 172 (-4.2A)
None
None
1.25A 3rnjA-1khcA:
2.5
3rnjA-1khcA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
5 / 12 GLN A 269
GLY A 272
GLY A 274
ASP A 273
ALA A 308
UNX  A 166 (-3.8A)
UNX  A 164 (-3.9A)
UNX  A 166 ( 3.6A)
None
None
1.28A 3t7sB-1khcA:
undetectable
3t7sB-1khcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
5 / 12 GLN A 269
GLY A 272
GLY A 274
ASP A 273
SER A 304
UNX  A 166 (-3.8A)
UNX  A 164 (-3.9A)
UNX  A 166 ( 3.6A)
None
None
1.34A 3t7sB-1khcA:
undetectable
3t7sB-1khcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
5 / 12 GLN A 269
GLY A 272
GLY A 274
ASP A 273
ALA A 308
UNX  A 166 (-3.8A)
UNX  A 164 (-3.9A)
UNX  A 166 ( 3.6A)
None
None
1.27A 3t7sD-1khcA:
undetectable
3t7sD-1khcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.86A 3wg7N-1khcA:
undetectable
3wg7W-1khcA:
0.0
3wg7N-1khcA:
13.81
3wg7W-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.96A 5b1aA-1khcA:
undetectable
5b1aJ-1khcA:
undetectable
5b1aA-1khcA:
13.81
5b1aJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.84A 5b1bN-1khcA:
undetectable
5b1bW-1khcA:
undetectable
5b1bN-1khcA:
13.81
5b1bW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.91A 5b3sA-1khcA:
undetectable
5b3sJ-1khcA:
undetectable
5b3sA-1khcA:
13.81
5b3sJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.93A 5iy5A-1khcA:
undetectable
5iy5J-1khcA:
0.0
5iy5A-1khcA:
13.81
5iy5J-1khcA:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TRP A 270
ASP A 273
LYS A 275
SER A 304
None
0.29A 5nr3A-1khcA:
24.9
5nr3A-1khcA:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.79A 5w97J-1khcA:
undetectable
5w97J-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
1.08A 5wauJ-1khcA:
undetectable
5wauJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.98A 5x1fW-1khcA:
undetectable
5x1fW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.87A 5xdqA-1khcA:
undetectable
5xdqJ-1khcA:
0.0
5xdqA-1khcA:
13.81
5xdqJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 5 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.89A 5z86J-1khcA:
undetectable
5z86J-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.96A 5z86N-1khcA:
undetectable
5z86W-1khcA:
undetectable
5z86N-1khcA:
13.81
5z86W-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 6 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.97A 5zcoN-1khcA:
undetectable
5zcoW-1khcA:
undetectable
5zcoN-1khcA:
13.81
5zcoW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus
musculus)
4 / 7 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.96A 5zcqA-1khcA:
undetectable
5zcqJ-1khcA:
undetectable
5zcqA-1khcA:
13.81
5zcqJ-1khcA:
21.13