SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1khh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 ASP A 134
ILE A 228
VAL A 232
 SAH  A 236 (-3.4A)
None
None
 0.63A 2avvD-1khhA:
undetectable		 2avvD-1khhA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 GLY A  67
GLU A  89
ASP A 134
 SAH  A 236 (-3.3A)
SAH  A 236 (-2.8A)
SAH  A 236 (-3.4A)
 0.39A 2b25B-1khhA:
12.3		 2b25B-1khhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 5 GLY A 162
GLY A 163
PHE A 156
PHE A 201
 None
 1.06A 2qr2A-1khhA:
2.8
2qr2B-1khhA:
3.0		 2qr2A-1khhA:
22.73
2qr2B-1khhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 ILE A 131
ALA A  56
GLN A 147
ILE A 206
LEU A 196
 None
 1.10A 2w3mA-1khhA:
undetectable		 2w3mA-1khhA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 GLY A  67
ILE A  88
GLU A  89
ASP A 134
 SAH  A 236 (-3.3A)
None
SAH  A 236 (-2.8A)
SAH  A 236 (-3.4A)
 0.30A 3a7eA-1khhA:
13.4		 3a7eA-1khhA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 7 LEU A 196
ALA A 155
GLY A 163
ILE A 164
 None
 0.87A 3spkB-1khhA:
undetectable		 3spkB-1khhA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 5 LEU A  52
ALA A  54
MET A 211
THR A 229
 None
 1.41A 3vasB-1khhA:
2.8		 3vasB-1khhA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 GLY A  69
GLU A  89
ASP A 134
GLU A 117
 SAH  A 236 (-3.2A)
SAH  A 236 (-2.8A)
SAH  A 236 (-3.4A)
SAH  A 236 (-3.3A)
 0.71A 3vywC-1khhA:
8.8		 3vywC-1khhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 PRO A 230
LEU A  52
TYR A 167
TRP A 173
 None
 0.72A 4pwdA-1khhA:
0.0		 4pwdA-1khhA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 PRO A 230
TYR A 167
TRP A 173
LEU A 170
 None
 0.91A 4pwdA-1khhA:
0.0		 4pwdA-1khhA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		4 / 7 GLY A  67
GLY A  69
GLU A  89
ASP A 134
 SAH  A 236 (-3.3A)
SAH  A 236 (-3.2A)
SAH  A 236 (-2.8A)
SAH  A 236 (-3.4A)
 0.56A 5ergB-1khhA:
12.7		 5ergB-1khhA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1khh GUANIDINOACETATE
METHYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 GLY A 163
GLY A 130
THR A 233
ASN A 205
GLN A 202
 None
 1.20A 6exiC-1khhA:
3.3
6exiD-1khhA:
2.2		 6exiC-1khhA:
18.08
6exiD-1khhA:
18.08