SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		3 / 3 ASP A 356
GLU A 267
TYR A 338
 None
 0.83A 1wsvA-1khoA:
undetectable		 1wsvA-1khoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		5 / 12 PHE A 185
ILE A 179
ALA A 124
SER A 102
SER A 189
 None
 1.32A 3apwA-1khoA:
undetectable		 3apwA-1khoA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		3 / 3 GLU A  30
SER A 244
VAL A 243
 None
 0.81A 3eeoA-1khoA:
undetectable		 3eeoA-1khoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 5 GLN A  97
THR A  93
THR A 133
HIS A 126
 None
None
None
ZN  A 372 (-3.4A)
 1.17A 3g1uC-1khoA:
undetectable		 3g1uC-1khoA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		3 / 3 SER A  96
ASP A  75
ASP A  67
 None
 0.89A 3iv6A-1khoA:
undetectable		 3iv6A-1khoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 6 THR A 306
GLN A 304
TYR A 261
ILE A 346
 None
 1.03A 3peoG-1khoA:
0.0		 3peoG-1khoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 7 ILE A  21
GLY A  18
SER A 233
PHE A 196
 None
 0.84A 3v7pA-1khoA:
undetectable		 3v7pA-1khoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		5 / 9 SER A 303
GLY A 302
TYR A 338
GLY A 265
THR A 264
 None
 1.42A 4lb0A-1khoA:
0.0		 4lb0A-1khoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 7 GLU A 289
THR A 291
THR A 272
ASN A 364
 None
 1.11A 4pfjA-1khoA:
undetectable		 4pfjA-1khoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 7 PHE A 192
ILE A 179
PHE A 196
GLY A 231
 None
 0.88A 4ze3A-1khoA:
1.8		 4ze3A-1khoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 8 PHE A 192
ILE A 179
PHE A 196
GLY A 231
 None
 0.93A 5esfA-1khoA:
undetectable		 5esfA-1khoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 7 ASN A 182
SER A 187
GLY A 349
ARG A 238
 None
 0.87A 5fpdB-1khoA:
undetectable		 5fpdB-1khoA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		3 / 3 ASP A  75
ASN A  77
PHE A  69
 None
 0.89A 5jglB-1khoA:
undetectable		 5jglB-1khoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		5 / 10 TYR A 338
PRO A 340
ILE A 262
ILE A 343
TYR A 367
 None
 1.47A 5mvnD-1khoA:
3.5		 5mvnD-1khoA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		3 / 3 TYR A 235
SER A 233
TRP A 188
 None
 1.02A 5n8jB-1khoA:
0.0		 5n8jB-1khoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		3 / 3 TYR A 235
SER A 233
TRP A 188
 None
 0.99A 5n8jA-1khoA:
undetectable		 5n8jA-1khoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		3 / 3 TYR A 235
SER A 233
TRP A 188
 None
 1.03A 5n8jD-1khoA:
undetectable		 5n8jD-1khoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		3 / 3 GLU A 108
ARG A 111
TYR A 107
 None
 0.67A 5trqB-1khoA:
0.3		 5trqB-1khoA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 6 GLU A  30
TYR A 237
GLY A 234
GLY A 231
 None
 0.66A 5x7pB-1khoA:
undetectable		 5x7pB-1khoA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kho ALPHA-TOXIN
(Clostridium
perfringens) 		4 / 8 GLN A 161
ILE A  14
ALA A 224
VAL A 223
 None
 0.74A 6hu9a-1khoA:
0.0
6hu9e-1khoA:
0.0		 6hu9a-1khoA:
19.78
6hu9e-1khoA:
17.57