SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1khu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 1khu SMAD1
(Homo
sapiens) 		3 / 3 THR A 369
THR A 370
PRO A 368
 None
 0.84A 1mnvD-1khuA:
undetectable		 1mnvD-1khuA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1khu SMAD1
(Homo
sapiens) 		5 / 12 ILE A 436
GLY A 333
VAL A 296
SER A 351
TYR A 276
 None
 1.34A 1nbhA-1khuA:
undetectable		 1nbhA-1khuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1khu SMAD1
(Homo
sapiens) 		5 / 12 ILE A 436
GLY A 333
VAL A 296
SER A 351
TYR A 276
 None
 1.34A 1nbhC-1khuA:
undetectable		 1nbhC-1khuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1khu SMAD1
(Homo
sapiens) 		5 / 12 ILE A 436
GLY A 333
VAL A 296
SER A 351
TYR A 276
 None
 1.35A 1nbhD-1khuA:
undetectable		 1nbhD-1khuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1khu SMAD1
(Homo
sapiens) 		4 / 8 CYH A 434
THR A 322
ILE A 323
THR A 326
 None
 0.93A 3bpxA-1khuA:
0.0
3bpxB-1khuA:
0.0		 3bpxA-1khuA:
20.83
3bpxB-1khuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1khu SMAD1
(Homo
sapiens) 		4 / 8 GLU A 387
ASN A 385
ASN A 359
ILE A 382
 None
 1.20A 3kp6A-1khuA:
undetectable
3kp6B-1khuA:
0.0		 3kp6A-1khuA:
18.58
3kp6B-1khuA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1khu SMAD1
(Homo
sapiens) 		3 / 3 PHE A 366
CYH A 360
HIS A 364
 None
 1.26A 3u9fF-1khuA:
0.0		 3u9fF-1khuA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1khu SMAD1
(Homo
sapiens) 		3 / 3 PHE A 366
CYH A 360
HIS A 364
 None
 1.29A 3u9fL-1khuA:
0.0		 3u9fL-1khuA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1khu SMAD1
(Homo
sapiens) 		3 / 3 PHE A 366
CYH A 360
HIS A 364
 None
 1.15A 3u9fS-1khuA:
0.0		 3u9fS-1khuA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1khu SMAD1
(Homo
sapiens) 		3 / 3 ARG A 319
TYR A 276
GLU A 278
 None
 0.58A 4zzbE-1khuA:
undetectable		 4zzbE-1khuA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1khu SMAD1
(Homo
sapiens) 		5 / 8 VAL A 294
ILE A 274
ILE A 438
ILE A 412
SER A 379
 None
 1.32A 5numA-1khuA:
undetectable		 5numA-1khuA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 1khu SMAD1
(Homo
sapiens) 		5 / 12 LEU A 440
GLY A 442
ASN A 385
GLU A 387
LEU A 392
 None
 1.09A 5nwvA-1khuA:
0.0		 5nwvA-1khuA:
12.38