SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1khw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 7 ASP A 250
TYR A 352
ASP A 354
ASP A 355
 MN  A 602 ( 2.6A)
None
MN  A 601 ( 2.3A)
MN  A 601 (-4.0A)
 0.90A 1t03A-1khwA:
4.9		 1t03A-1khwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 MET A 227
THR A 240
LEU A 239
ILE A 236
VAL A 232
 None
 1.21A 1wsvA-1khwA:
0.0		 1wsvA-1khwA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 THR A  16
GLU A  78
HIS A 290
 None
 0.91A 1xwfA-1khwA:
0.0		 1xwfA-1khwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 THR A  16
GLU A  78
HIS A 290
 None
 0.91A 1xwfD-1khwA:
0.0		 1xwfD-1khwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 6 LEU A  99
TYR A  98
ILE A 319
GLY A 219
 None
 0.94A 2du8B-1khwA:
undetectable		 2du8B-1khwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 5 PHE A 129
PHE A   5
HIS A 165
VAL A 197
 None
 1.25A 2lh6A-1khwA:
0.0		 2lh6A-1khwA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 ALA A 492
ALA A 461
ARG A 499
PHE A 468
LEU A 426
 None
 1.04A 2nyrA-1khwA:
undetectable		 2nyrA-1khwA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 PHE A 401
THR A 228
VAL A 225
GLY A 224
ALA A 222
 None
 1.24A 2x2iA-1khwA:
undetectable		 2x2iA-1khwA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 PHE A 401
THR A 228
VAL A 225
GLY A 224
ALA A 222
 None
 1.25A 2x2iC-1khwA:
undetectable		 2x2iC-1khwA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 HIS A 321
LEU A 343
LEU A 249
LEU A 375
TYR A 251
 None
 1.33A 3cs8A-1khwA:
0.0		 3cs8A-1khwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 VAL A 223
TYR A 168
ILE A 319
HIS A 166
VAL A 197
 None
 1.39A 3g8iA-1khwA:
0.0		 3g8iA-1khwA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 5 ARG A 188
ASP A 250
ASP A 354
ASP A 355
 None
MN  A 602 ( 2.6A)
MN  A 601 ( 2.3A)
MN  A 601 (-4.0A)
 1.29A 3naiA-1khwA:
38.5		 3naiA-1khwA:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 5 ARG A 188
ASP A 250
ASP A 354
ASP A 355
 None
MN  A 602 ( 2.6A)
MN  A 601 ( 2.3A)
MN  A 601 (-4.0A)
 1.09A 3naiC-1khwA:
38.7		 3naiC-1khwA:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		7 / 9 ASP A 255
SER A 308
ASN A 317
TYR A 352
GLY A 353
ASP A 354
ASP A 355
 None
None
None
None
None
MN  A 601 ( 2.3A)
MN  A 601 (-4.0A)
 0.70A 3sfuA-1khwA:
37.1		 3sfuA-1khwA:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		7 / 9 ASP A 255
ASN A 317
TYR A 352
GLY A 353
ASP A 354
ASP A 355
LEU A 402
 None
None
None
None
MN  A 601 ( 2.3A)
MN  A 601 (-4.0A)
None
 0.42A 3sfuB-1khwA:
37.5		 3sfuB-1khwA:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		6 / 11 ASP A 255
LEU A 306
THR A 313
ASN A 317
GLY A 353
ASP A 354
 None
None
None
None
None
MN  A 601 ( 2.3A)
 0.82A 3sfuC-1khwA:
37.3		 3sfuC-1khwA:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		6 / 11 ASP A 255
SER A 308
THR A 313
ASN A 317
GLY A 353
ASP A 354
 None
None
None
None
None
MN  A 601 ( 2.3A)
 0.77A 3sfuC-1khwA:
37.3		 3sfuC-1khwA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 ILE A 269
LEU A 324
LEU A 265
ILE A  88
ILE A 221
 None
 0.98A 3vrmA-1khwA:
0.0		 3vrmA-1khwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 LEU A 323
SER A 326
LEU A 265
LEU A  96
ILE A 269
 None
 1.06A 4x1fA-1khwA:
0.0		 4x1fA-1khwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 6 PHE A 349
SER A 326
VAL A 329
ASP A 346
 None
 1.25A 5hesA-1khwA:
undetectable		 5hesA-1khwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 ALA A  68
ASN A  71
LEU A  72
 None
 0.47A 5i1nC-1khwA:
undetectable		 5i1nC-1khwA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 LYS A 253
TRP A 254
SER A 256
 None
 1.39A 5nwwA-1khwA:
undetectable		 5nwwA-1khwA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 4 GLU A 440
THR A 441
THR A  32
LEU A 176
 None
 1.42A 5v96A-1khwA:
undetectable		 5v96A-1khwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 4 GLU A 440
THR A 441
THR A  32
LEU A 176
 None
 1.42A 5v96C-1khwA:
undetectable		 5v96C-1khwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 4 GLU A 440
THR A 441
THR A  32
LEU A 176
 None
 1.42A 5v96D-1khwA:
undetectable		 5v96D-1khwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 4 GLU A 455
VAL A 458
LEU A 496
THR A 228
 None
 1.46A 6dynA-1khwA:
0.0		 6dynA-1khwA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		4 / 5 GLU A 455
VAL A 458
LEU A 496
THR A 228
 None
 1.47A 6dyoA-1khwA:
0.0		 6dyoA-1khwA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1khw RNA-DIRECTED RNA
POLYMERASE
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 ILE A 221
VAL A 223
ILE A 269
PHE A 205
MET A 310
 None
 1.39A 6j21A-1khwA:
0.0		 6j21A-1khwA:
20.70