SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kjn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1kjn MTH0777
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PHE A 111
PHE A  98
ALA A  99
THR A 106
ALA A 108
 None
 1.15A 2j0dA-1kjnA:
0.0		 2j0dA-1kjnA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1kjn MTH0777
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 VAL A  65
ALA A  43
THR A  61
SER A  29
PHE A  81
 None
 1.10A 3hbbB-1kjnA:
2.1		 3hbbB-1kjnA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1kjn MTH0777
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ILE A 133
ALA A 108
THR A 106
ALA A  99
 None
 1.07A 3mdrB-1kjnA:
undetectable		 3mdrB-1kjnA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 1kjn MTH0777
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 THR A  28
ILE A 149
PHE A  85
LEU A 107
 None
 1.17A 3tf1A-1kjnA:
0.0		 3tf1A-1kjnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kjn MTH0777
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLY A  14
ALA A 108
ILE A 125
LEU A 121
LEU A 118
 None
 1.09A 4xumB-1kjnA:
undetectable		 4xumB-1kjnA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1kjn MTH0777
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 PHE A  37
THR A  40
ASP A  78
GLU A  80
 None
 1.46A 5ybbA-1kjnA:
undetectable		 5ybbA-1kjnA:
15.52